ID   E7D8R1_CLOPF            Unreviewed;       334 AA.
AC   E7D8R1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Epsilon-toxin {ECO:0000313|EMBL:ADU04573.1};
DE   Flags: Fragment;
GN   Name=etx {ECO:0000313|EMBL:ADU04573.1};
OS   Clostridium perfringens D.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=107819 {ECO:0000313|EMBL:ADU04573.1};
RN   [1] {ECO:0000313|EMBL:ADU04573.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CWD CN 409 {ECO:0000313|EMBL:ADU04573.1};
RA   Pilehchian Langroudi R., Aghaei Pour K., Shamsara M., Ghorashi S.A.;
RT   "Fusion of Clostridium perfringens type D and B epsilon and beta toxin
RT   genes and it's cloning in E. coli.";
RL   Arch Razi Inst 66:1-10(2011).
RN   [2] {ECO:0000313|EMBL:ADU04573.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CWD CN 409 {ECO:0000313|EMBL:ADU04573.1};
RA   Pilehchian Langroudi R., Aghaei Pour K., Shamsara M., Ghorashi S.A.;
RT   "In silico fusion of epsilon and beta toxin genes of Clostridium
RT   perfringens types D and B.";
RL   Iran. J. Biotechnol. 10:54-60(2012).
RN   [3] {ECO:0007829|PDB:3ZJX}
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 47-328.
RX   PubMed=23504825; DOI=10.1002/PRO.2250;
RA   Bokori-Brown M., Kokkinidou M.C., Savva C.G., Fernandes da Costa S.,
RA   Naylor C.E., Cole A.R., Moss D.S., Basak A.K., Titball R.W.;
RT   "Clostridium perfringens epsilon toxin H149A mutant as a platform for
RT   receptor binding studies.";
RL   Protein Sci. 22:650-659(2013).
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DR   EMBL; HQ179546; ADU04573.1; -; Genomic_DNA.
DR   PDB; 3ZJX; X-ray; 2.40 A; A/B/C/D=47-328.
DR   PDBsum; 3ZJX; -.
DR   AlphaFoldDB; E7D8R1; -.
DR   SMR; E7D8R1; -.
DR   MINT; E7D8R1; -.
DR   CDD; cd20223; PFM_epsilon-toxin-like; 1.
DR   Gene3D; 3.30.360.60; -; 1.
DR   Gene3D; 2.170.15.10; Proaerolysin, chain A, domain 3; 2.
DR   InterPro; IPR004991; Aerolysin-like.
DR   InterPro; IPR009209; Epsilon_toxin.
DR   Pfam; PF03318; ETX_MTX2; 1.
DR   PIRSF; PIRSF026587; Epsilon_toxin; 1.
DR   SUPFAM; SSF56973; Aerolisin/ETX pore-forming domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3ZJX}.
FT   NON_TER         334
FT                   /evidence="ECO:0000313|EMBL:ADU04573.1"
SQ   SEQUENCE   334 AA;  36862 MW;  8C80F71E3E30B0B6 CRC64;
     MKKNLVKSLA IASAVISIYS IVNIVSPTNV IAKEISNTVS NEMSKKASYD NVDTLIEKGR
     YNTKYNYLKR MEKYYPNAMA YFDKVTINPQ GNDFYINNPK VELDGEPSMN YLEDVYVGKA
     LLTNDTQQEQ KLKSQSFTCK NTDTVTATTT HTVGTSIQAT AKFTVPFNET GVSLTTSYSF
     ANTNTNTNSK EITHNVPSQD ILVPANTTVE VIAYLKKVNV KGNVKLVGQV SGSEWGEIPS
     YLAFPRDGYK FSLSDTVNKS DLNEDGTINI NGKGNYSAVM GDELIVKVRN LNTNNVQEYV
     IPVDKKEKSN DSNIVKYRSL SIKAPGIKAE AAAK
//