E7BGW8 (E7BGW8_NEIMW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase IDH) EMBL CBY90597.1
EC=1.1.1.42 EMBL CBY90597.1

Gene names

Name:	icd EMBL CBY90597.1
Ordered Locus Names:	NMAA_0720 EMBL CBY90597.1

Organism

Neisseria meningitidis serogroup A (strain WUE 2594) [Complete proteome] [HAMAP] EMBL CBY90597.1

Taxonomic identifier

942513 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL CBY90597.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	133 – 140	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	351	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	549	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	553	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	146	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	548	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	256	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	421	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	E7BGW8 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: 3786D2E2958212B5	FASTA	741	80,077
	10 20 30 40 50 60 MTQKSTIVYT HTDEAPALAT QSLLPIVQAF ARHADIDVKT ADISLSGRIL AAFPEYLTEA 70 80 90 100 110 120 QRVPDALAEL GELVKQPDAN VIKLPNISAS VPQLTAAIKE LQSKGFAVPD YPADPQTDEE 130 140 150 160 170 180 KAVRERYDRI KGSAVNPVLR EGNSDRRAPK AVKNFAKKNP HSMGAWAKDS KTHVATMQSG 190 200 210 220 230 240 DFFHNEQSVT VPDATSVSIV FTDKQGNKKE LRDPVALKAG EIIDATVMSK KALLAFLAEQ 250 260 270 280 290 300 VKDAKAKGVL FSLHMKATMM KVSDPIIFGH AVKVFFAPVF EKFGDKLAAA GVNVNNGFGN 310 320 330 340 350 360 LLANLDKLDA DTRAAVEAEI AAVYAANPDL AMVDSDKGIT NLHVPSDVIV DASMPAMIRN 370 380 390 400 410 420 SGRMWDKNGK AQDTKAVIPD SSYAGVYQAT IDFCREHGAF DPTTMGTVPN VGLMAQAAEE 430 440 450 460 470 480 YGSHNKTFEI EADGQVQVVD AAGKVLMQHD VEAGDIWRMC QTKDDPVKDW VQLAVNRARL 490 500 510 520 530 540 SNTPAVFWLD ENRPHDKSLL AKVKAYLAEL DTNGLDIRVL APEEAAKFSL GRLKNGEDTI 550 560 570 580 590 600 SVTGNVLRDY LTDLFPILEL GTSAKMLSIV PLMNGGGMFE TGAGGSAPKH VQQFLEENHL 610 620 630 640 650 660 RWDSLGEFLA LAVSFEHLAQ KTGNAKAQVL ADTLDAATEK LLLNDKSPKR KAGELDNRGS 670 680 690 700 710 720 HFYLTLYWAQ ELAAQDKDAE LKAAFTPLAA ALTADEAKIV AELSAVQGKA ADIGGYYAAN 730 740 PEKAAQVMRP SVTFNQALNA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594." Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M. J. Bacteriol. 193:2064-2065(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WUE 2594 EMBL CBY90597.1.
[2]	""Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594"." Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M. Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: WUE 2594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR774048 Genomic DNA. Translation: CBY90597.1.
RefSeq	YP_005891715.1. NC_017512.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CBY90597; CBY90597; NMAA_0720.
GeneID	12408298.
KEGG	nmw:NMAA_0720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E7BGW8_NEIMW

Accession

Primary (citable) accession number: E7BGW8

Entry history

Integrated into UniProtKB/TrEMBL:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)