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E7BGW8

- E7BGW8_NEIMW

UniProt

E7BGW8 - E7BGW8_NEIMW

Protein
Submitted name:

Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase IDH)

Gene

icd

Organism
Neisseria meningitidis serogroup A (strain WUE 2594)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461SubstrateUniRule annotation
    Sitei256 – 2561Critical for catalysis
    Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
    Sitei421 – 4211Critical for catalysisUniRule annotation
    Binding sitei548 – 5481SubstrateUniRule annotation
    Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
    Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciNMEN942513:GLHV-801-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase IDH)Imported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:NMAA_0720Imported
    OrganismiNeisseria meningitidis serogroup A (strain WUE 2594)Imported
    Taxonomic identifieri942513 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000008638: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1408Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E7BGW8-1 [UniParc]FASTAAdd to Basket

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    MTQKSTIVYT HTDEAPALAT QSLLPIVQAF ARHADIDVKT ADISLSGRIL    50
    AAFPEYLTEA QRVPDALAEL GELVKQPDAN VIKLPNISAS VPQLTAAIKE 100
    LQSKGFAVPD YPADPQTDEE KAVRERYDRI KGSAVNPVLR EGNSDRRAPK 150
    AVKNFAKKNP HSMGAWAKDS KTHVATMQSG DFFHNEQSVT VPDATSVSIV 200
    FTDKQGNKKE LRDPVALKAG EIIDATVMSK KALLAFLAEQ VKDAKAKGVL 250
    FSLHMKATMM KVSDPIIFGH AVKVFFAPVF EKFGDKLAAA GVNVNNGFGN 300
    LLANLDKLDA DTRAAVEAEI AAVYAANPDL AMVDSDKGIT NLHVPSDVIV 350
    DASMPAMIRN SGRMWDKNGK AQDTKAVIPD SSYAGVYQAT IDFCREHGAF 400
    DPTTMGTVPN VGLMAQAAEE YGSHNKTFEI EADGQVQVVD AAGKVLMQHD 450
    VEAGDIWRMC QTKDDPVKDW VQLAVNRARL SNTPAVFWLD ENRPHDKSLL 500
    AKVKAYLAEL DTNGLDIRVL APEEAAKFSL GRLKNGEDTI SVTGNVLRDY 550
    LTDLFPILEL GTSAKMLSIV PLMNGGGMFE TGAGGSAPKH VQQFLEENHL 600
    RWDSLGEFLA LAVSFEHLAQ KTGNAKAQVL ADTLDAATEK LLLNDKSPKR 650
    KAGELDNRGS HFYLTLYWAQ ELAAQDKDAE LKAAFTPLAA ALTADEAKIV 700
    AELSAVQGKA ADIGGYYAAN PEKAAQVMRP SVTFNQALNA L 741
    Length:741
    Mass (Da):80,077
    Last modified:March 8, 2011 - v1
    Checksum:i3786D2E2958212B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR774048 Genomic DNA. Translation: CBY90597.1.
    RefSeqiYP_005891715.1. NC_017512.1.

    Genome annotation databases

    EnsemblBacteriaiCBY90597; CBY90597; NMAA_0720.
    GeneIDi12408298.
    KEGGinmw:NMAA_0720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR774048 Genomic DNA. Translation: CBY90597.1 .
    RefSeqi YP_005891715.1. NC_017512.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBY90597 ; CBY90597 ; NMAA_0720 .
    GeneIDi 12408298.
    KEGGi nmw:NMAA_0720.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci NMEN942513:GLHV-801-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594."
      Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M.
      J. Bacteriol. 193:2064-2065(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WUE 2594Imported.
    2. ""Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594"."
      Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WUE 2594.

    Entry informationi

    Entry nameiE7BGW8_NEIMW
    AccessioniPrimary (citable) accession number: E7BGW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3