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E7BGW8

- E7BGW8_NEIMW

UniProt

E7BGW8 - E7BGW8_NEIMW

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Protein
Submitted name:

Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase IDH)

Gene

icd

Organism
Neisseria meningitidis serogroup A (strain WUE 2594)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciNMEN942513:GLHV-801-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase IDH)Imported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:NMAA_0720Imported
OrganismiNeisseria meningitidis serogroup A (strain WUE 2594)Imported
Taxonomic identifieri942513 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000008638: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

E7BGW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQKSTIVYT HTDEAPALAT QSLLPIVQAF ARHADIDVKT ADISLSGRIL
60 70 80 90 100
AAFPEYLTEA QRVPDALAEL GELVKQPDAN VIKLPNISAS VPQLTAAIKE
110 120 130 140 150
LQSKGFAVPD YPADPQTDEE KAVRERYDRI KGSAVNPVLR EGNSDRRAPK
160 170 180 190 200
AVKNFAKKNP HSMGAWAKDS KTHVATMQSG DFFHNEQSVT VPDATSVSIV
210 220 230 240 250
FTDKQGNKKE LRDPVALKAG EIIDATVMSK KALLAFLAEQ VKDAKAKGVL
260 270 280 290 300
FSLHMKATMM KVSDPIIFGH AVKVFFAPVF EKFGDKLAAA GVNVNNGFGN
310 320 330 340 350
LLANLDKLDA DTRAAVEAEI AAVYAANPDL AMVDSDKGIT NLHVPSDVIV
360 370 380 390 400
DASMPAMIRN SGRMWDKNGK AQDTKAVIPD SSYAGVYQAT IDFCREHGAF
410 420 430 440 450
DPTTMGTVPN VGLMAQAAEE YGSHNKTFEI EADGQVQVVD AAGKVLMQHD
460 470 480 490 500
VEAGDIWRMC QTKDDPVKDW VQLAVNRARL SNTPAVFWLD ENRPHDKSLL
510 520 530 540 550
AKVKAYLAEL DTNGLDIRVL APEEAAKFSL GRLKNGEDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPILEL GTSAKMLSIV PLMNGGGMFE TGAGGSAPKH VQQFLEENHL
610 620 630 640 650
RWDSLGEFLA LAVSFEHLAQ KTGNAKAQVL ADTLDAATEK LLLNDKSPKR
660 670 680 690 700
KAGELDNRGS HFYLTLYWAQ ELAAQDKDAE LKAAFTPLAA ALTADEAKIV
710 720 730 740
AELSAVQGKA ADIGGYYAAN PEKAAQVMRP SVTFNQALNA L
Length:741
Mass (Da):80,077
Last modified:March 8, 2011 - v1
Checksum:i3786D2E2958212B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR774048 Genomic DNA. Translation: CBY90597.1.
RefSeqiYP_005891715.1. NC_017512.1.

Genome annotation databases

EnsemblBacteriaiCBY90597; CBY90597; NMAA_0720.
GeneIDi12408298.
KEGGinmw:NMAA_0720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR774048 Genomic DNA. Translation: CBY90597.1 .
RefSeqi YP_005891715.1. NC_017512.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBY90597 ; CBY90597 ; NMAA_0720 .
GeneIDi 12408298.
KEGGi nmw:NMAA_0720.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci NMEN942513:GLHV-801-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594."
    Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M.
    J. Bacteriol. 193:2064-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WUE 2594Imported.
  2. ""Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594"."
    Schoen C., Weber-Lehmann J., Blom J., Joseph B., Goesmann A., Strittmatter A., Frosch M.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WUE 2594.

Entry informationi

Entry nameiE7BGW8_NEIMW
AccessioniPrimary (citable) accession number: E7BGW8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3