ID   E7ADB0_HELFC            Unreviewed;       875 AA.
AC   E7ADB0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419};
GN   Name=ppc {ECO:0000313|EMBL:CBY83167.1};
GN   OrderedLocusNames=Hfelis_10830 {ECO:0000313|EMBL:CBY83167.1};
OS   Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=936155 {ECO:0000313|EMBL:CBY83167.1, ECO:0000313|Proteomes:UP000007934};
RN   [1] {ECO:0000313|Proteomes:UP000007934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49179 / NCTC 12436 / CS1
RC   {ECO:0000313|Proteomes:UP000007934};
RA   Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M.,
RA   Muller A.;
RT   "Comparative whole genome analysis of the carcinogenic bacterial pathogen
RT   Helicobacter felis.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBY83167.1, ECO:0000313|Proteomes:UP000007934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49179 / NCTC 12436 / CS1
RC   {ECO:0000313|Proteomes:UP000007934};
RX   PubMed=21402865;
RA   Arnold I.C., Zigova Z., Holden M., Lawley T.D., Rad R., Dougan G.,
RA   Falkow S., Bentley S.D., Muller A.;
RT   "Comparative whole genome sequence analysis of the carcinogenic bacterial
RT   model pathogen Helicobacter felis.";
RL   Genome Biol. Evol. 3:302-308(2011).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00001071};
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DR   EMBL; FQ670179; CBY83167.1; -; Genomic_DNA.
DR   RefSeq; WP_013469531.1; NC_014810.2.
DR   AlphaFoldDB; E7ADB0; -.
DR   STRING; 936155.HFELIS_10830; -.
DR   GeneID; 36133666; -.
DR   KEGG; hfe:HFELIS_10830; -.
DR   eggNOG; COG2352; Bacteria.
DR   HOGENOM; CLU_006557_2_0_7; -.
DR   OrthoDB; 9768133at2; -.
DR   Proteomes; UP000007934; Chromosome.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:InterPro.
DR   GO; GO:0015977; P:carbon fixation; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CBY83167.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Pyruvate {ECO:0000313|EMBL:CBY83167.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007934}.
FT   ACT_SITE        125
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10111"
FT   ACT_SITE        542
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10112"
SQ   SEQUENCE   875 AA;  99769 MW;  E375433AA9A3C137 CRC64;
     MRQHPQVERE LEFLHDLVVN VLDTFSPTIT NHFLRLKNLF ENTEHSQEQI EIAFREIAAS
     EQILGVIKAF SLYNILINIV EERHKNQQPA RLQETYQELL DTGFEAKKLK GVLENIQFYP
     VFTAHPTESM RRTFLEAIQE MYHDLSLVFD NACNQDMVTH AKKHLNYRLG LLWKSHLIRQ
     ERLEVLFELD NLLYILQHSI LPSCRDLLGT IQKMLDKPLE HCPLCLGSWI GGDRDGNPFV
     SNALLQQVVS IQHEFIIKTY LEYTAKLQRE LSIALDFCPI SEALKIDLQD SYHQLDPTSA
     RLHVKEPFRA KLILMEQKLK NRLIALSAPL EIEFAYKNPR ELLEDIDLLL ENLEPSLSQP
     LLDFRHLVLL AGFHLLSLDF REHRDVFLYA ISEVFCHLGL ATSDFYALEE EAKLEILSHA
     LSQEPTTLQS LMVSPECKRL LEAFSHIVWA KSRIGAEIFH SIIVSMTTQA SDLLCVLWLA
     KQSRLVSKNL KIYITPLFET IADLQHAQVI MRTLSQNPHY RAYLEIMEFK QAIMVGYSDS
     SKDGGIFASN YNLHNAISAL VDLEQELGIK FILFHGRGGS VSRGGGDLQN ALLSAPAHSV
     KTTLKLTEQG ETISSRYLNP ASAHSNLANV MGALLKKNTL DRYSPLPKVP LHSSLKTISE
     VSYTTYRDLI YHTPGFLDYF KQATPIAFIQ ELNLGSRPSK RKESSKIEDL RAIPWVFAWT
     QNRSLLPAWY GVGSGLESVG DFEALRSLYG KDGFFKAVLD NIAQALLKVD LSIAKEYHKF
     AIHNPSALNI WERIEKEFVK TMRAVLIIRS EDKLLDKDPS VQEGILLRTP YINALNHLQI
     ALISAFKQQE GDLEQLKIYI HSTIVGIAQG MRNTG
//