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E7A9Z9

- E7A9Z9_HELFC

UniProt

E7A9Z9 - E7A9Z9_HELFC

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Protein

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Gene

gcpE

Organism
Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.UniRule annotation

Catalytic activityi

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 4Fe-4S cluster.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi266 – 2661Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi298 – 2981Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi305 – 3051Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity Source: UniProtKB-HAMAP
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHFEL936155:GHMC-1340-MONOMER.
UniPathwayiUPA00056; UER00096.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseUniRule annotation (EC:1.17.7.1UniRule annotation)
Alternative name(s):
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthaseUniRule annotation
Gene namesi
Name:gcpEImported
Synonyms:ispGUniRule annotation
Ordered Locus Names:HFELIS_13340Imported
OrganismiHelicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)Imported
Taxonomic identifieri936155 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007934: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the IspG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261019.
KOiK03526.
OMAiYGKPVRI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00159. IspG.
InterProiIPR013785. Aldolase_TIM.
IPR029065. Enolase_C-like.
IPR016425. IspG_bac.
IPR004588. IspG_bac-typ.
[Graphical view]
PfamiPF04551. GcpE. 1 hit.
[Graphical view]
PIRSFiPIRSF004640. IspG. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
TIGRFAMsiTIGR00612. ispG_gcpE. 1 hit.

Sequencei

Sequence statusi: Complete.

E7A9Z9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPRFPTQQI SIGHVLIGGD APISTQSMTF SQTCDIEATK AQIDRLKLAG
60 70 80 90 100
ADLVRVAVRH KKDALALKEL KKVASLPLIA DIHFHHHLAL IAAESVDAIR
110 120 130 140 150
INPGNIGAPE KIKAVAQACN ARNLPIRIGV NGGSLEKPFE LKYGATPEGM
160 170 180 190 200
VQSALYNIKF LEDAGFTNIK ISLKASDVER TIAAYQQLRP LVPYPFHLGV
210 220 230 240 250
TEAGSLFHSS IKSAMALGQL LREGIGDTMR VSITGELEEE IRVAKAILRY
260 270 280 290 300
SGRQKEGITF ISCPTCGRIE SNLVAMMSQV EQRLAHIKIP LDVSVMGCVV
310 320 330 340 350
NALGEAKHAD IAIAFGKKSG LIIKKGKVIH KLPEDQLLET FVTEVQTLAL
360
EQQKEDIHAK I
Length:361
Mass (Da):39,262
Last modified:March 8, 2011 - v1
Checksum:i2F1C03877B676EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ670179 Genomic DNA. Translation: CBY83418.1.
RefSeqiYP_004074008.1. NC_014810.2.

Genome annotation databases

EnsemblBacteriaiCBY83418; CBY83418; HFELIS_13340.
GeneIDi10050600.
KEGGihfe:HFELIS_13340.
PATRICi45240607. VBIHelFel178703_1380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ670179 Genomic DNA. Translation: CBY83418.1 .
RefSeqi YP_004074008.1. NC_014810.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBY83418 ; CBY83418 ; HFELIS_13340 .
GeneIDi 10050600.
KEGGi hfe:HFELIS_13340.
PATRICi 45240607. VBIHelFel178703_1380.

Phylogenomic databases

HOGENOMi HOG000261019.
KOi K03526.
OMAi YGKPVRI.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00096 .
BioCyci HFEL936155:GHMC-1340-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00159. IspG.
InterProi IPR013785. Aldolase_TIM.
IPR029065. Enolase_C-like.
IPR016425. IspG_bac.
IPR004588. IspG_bac-typ.
[Graphical view ]
Pfami PF04551. GcpE. 1 hit.
[Graphical view ]
PIRSFi PIRSF004640. IspG. 1 hit.
SUPFAMi SSF51604. SSF51604. 1 hit.
TIGRFAMsi TIGR00612. ispG_gcpE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative whole genome analysis of the carcinogenic bacterial pathogen Helicobacter felis."
    Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M., Muller A.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49179 / NCTC 12436 / CS1Imported.

Entry informationi

Entry nameiE7A9Z9_HELFC
AccessioniPrimary (citable) accession number: E7A9Z9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3