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E7A9Z9 (E7A9Z9_HELFC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase HAMAP-Rule MF_00159

EC=1.17.7.1 HAMAP-Rule MF_00159
Alternative name(s):
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase HAMAP-Rule MF_00159
Gene names
Name:gcpE EMBL CBY83418.1
Synonyms:ispG HAMAP-Rule MF_00159
Ordered Locus Names:HFELIS_13340 EMBL CBY83418.1
OrganismHelicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1) [Complete proteome] [HAMAP] EMBL CBY83418.1
Taxonomic identifier936155 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate By similarity. HAMAP-Rule MF_00159

Catalytic activity

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. HAMAP-Rule MF_00159 SAAS SAAS004588

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP-Rule MF_00159

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. HAMAP-Rule MF_00159 SAAS SAAS004588

Sequence similarities

Belongs to the IspG family. HAMAP-Rule MF_00159

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2631Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding2661Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding2981Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding3051Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159

Sequences

Sequence LengthMass (Da)Tools
E7A9Z9 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 2F1C03877B676EB3

FASTA36139,262
        10         20         30         40         50         60 
MHPRFPTQQI SIGHVLIGGD APISTQSMTF SQTCDIEATK AQIDRLKLAG ADLVRVAVRH 

        70         80         90        100        110        120 
KKDALALKEL KKVASLPLIA DIHFHHHLAL IAAESVDAIR INPGNIGAPE KIKAVAQACN 

       130        140        150        160        170        180 
ARNLPIRIGV NGGSLEKPFE LKYGATPEGM VQSALYNIKF LEDAGFTNIK ISLKASDVER 

       190        200        210        220        230        240 
TIAAYQQLRP LVPYPFHLGV TEAGSLFHSS IKSAMALGQL LREGIGDTMR VSITGELEEE 

       250        260        270        280        290        300 
IRVAKAILRY SGRQKEGITF ISCPTCGRIE SNLVAMMSQV EQRLAHIKIP LDVSVMGCVV 

       310        320        330        340        350        360 
NALGEAKHAD IAIAFGKKSG LIIKKGKVIH KLPEDQLLET FVTEVQTLAL EQQKEDIHAK 


I 

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References

[1]"Comparative whole genome analysis of the carcinogenic bacterial pathogen Helicobacter felis."
Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M., Muller A.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49179 / NCTC 12436 / CS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ670179 Genomic DNA. Translation: CBY83418.1.
RefSeqYP_004074008.1. NC_014810.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBY83418; CBY83418; HFELIS_13340.
GeneID10050600.
KEGGhfe:HFELIS_13340.
PATRIC45240607. VBIHelFel178703_1380.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000261019.
KOK03526.
OMAYGKPVRI.

Enzyme and pathway databases

BioCycHFEL936155:GHMC-1340-MONOMER.
UniPathwayUPA00056; UER00096.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00159. IspG.
InterProIPR013785. Aldolase_TIM.
IPR029065. Enolase_C-like.
IPR016425. IspG_bac.
IPR004588. IspG_bac-typ.
[Graphical view]
PfamPF04551. GcpE. 1 hit.
[Graphical view]
PIRSFPIRSF004640. IspG. 1 hit.
SUPFAMSSF51604. SSF51604. 1 hit.
TIGRFAMsTIGR00612. ispG_gcpE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE7A9Z9_HELFC
AccessionPrimary (citable) accession number: E7A9Z9
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)