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E7A9Z9

- E7A9Z9_HELFC

UniProt

E7A9Z9 - E7A9Z9_HELFC

Protein

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Gene

gcpE

Organism
Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.UniRule annotation

    Catalytic activityi

    (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi263 – 2631Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi266 – 2661Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi298 – 2981Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi305 – 3051Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity Source: UniProtKB-HAMAP
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciHFEL936155:GHMC-1340-MONOMER.
    UniPathwayiUPA00056; UER00096.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseUniRule annotation (EC:1.17.7.1UniRule annotation)
    Alternative name(s):
    1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthaseUniRule annotation
    Gene namesi
    Name:gcpEImported
    Synonyms:ispGUniRule annotation
    Ordered Locus Names:HFELIS_13340Imported
    OrganismiHelicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)Imported
    Taxonomic identifieri936155 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000007934: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IspG family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000261019.
    KOiK03526.
    OMAiYGKPVRI.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00159. IspG.
    InterProiIPR013785. Aldolase_TIM.
    IPR029065. Enolase_C-like.
    IPR016425. IspG_bac.
    IPR004588. IspG_bac-typ.
    [Graphical view]
    PfamiPF04551. GcpE. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004640. IspG. 1 hit.
    SUPFAMiSSF51604. SSF51604. 1 hit.
    TIGRFAMsiTIGR00612. ispG_gcpE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E7A9Z9-1 [UniParc]FASTAAdd to Basket

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    MHPRFPTQQI SIGHVLIGGD APISTQSMTF SQTCDIEATK AQIDRLKLAG    50
    ADLVRVAVRH KKDALALKEL KKVASLPLIA DIHFHHHLAL IAAESVDAIR 100
    INPGNIGAPE KIKAVAQACN ARNLPIRIGV NGGSLEKPFE LKYGATPEGM 150
    VQSALYNIKF LEDAGFTNIK ISLKASDVER TIAAYQQLRP LVPYPFHLGV 200
    TEAGSLFHSS IKSAMALGQL LREGIGDTMR VSITGELEEE IRVAKAILRY 250
    SGRQKEGITF ISCPTCGRIE SNLVAMMSQV EQRLAHIKIP LDVSVMGCVV 300
    NALGEAKHAD IAIAFGKKSG LIIKKGKVIH KLPEDQLLET FVTEVQTLAL 350
    EQQKEDIHAK I 361
    Length:361
    Mass (Da):39,262
    Last modified:March 8, 2011 - v1
    Checksum:i2F1C03877B676EB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ670179 Genomic DNA. Translation: CBY83418.1.
    RefSeqiYP_004074008.1. NC_014810.2.

    Genome annotation databases

    EnsemblBacteriaiCBY83418; CBY83418; HFELIS_13340.
    GeneIDi10050600.
    KEGGihfe:HFELIS_13340.
    PATRICi45240607. VBIHelFel178703_1380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ670179 Genomic DNA. Translation: CBY83418.1 .
    RefSeqi YP_004074008.1. NC_014810.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBY83418 ; CBY83418 ; HFELIS_13340 .
    GeneIDi 10050600.
    KEGGi hfe:HFELIS_13340.
    PATRICi 45240607. VBIHelFel178703_1380.

    Phylogenomic databases

    HOGENOMi HOG000261019.
    KOi K03526.
    OMAi YGKPVRI.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00096 .
    BioCyci HFEL936155:GHMC-1340-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00159. IspG.
    InterProi IPR013785. Aldolase_TIM.
    IPR029065. Enolase_C-like.
    IPR016425. IspG_bac.
    IPR004588. IspG_bac-typ.
    [Graphical view ]
    Pfami PF04551. GcpE. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004640. IspG. 1 hit.
    SUPFAMi SSF51604. SSF51604. 1 hit.
    TIGRFAMsi TIGR00612. ispG_gcpE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative whole genome analysis of the carcinogenic bacterial pathogen Helicobacter felis."
      Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M., Muller A.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49179 / NCTC 12436 / CS1Imported.

    Entry informationi

    Entry nameiE7A9Z9_HELFC
    AccessioniPrimary (citable) accession number: E7A9Z9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3