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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

sr13176

Organism
Sporisorium reilianum (strain SRZ2) (Maize head smut fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway:ibeta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathway:iphytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (sr13176)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:sr13176
OrganismiSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
Taxonomic identifieri999809 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeSporisorium
ProteomesiUP000008867 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11423HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Bifunctional lycopene cyclase/phytoene synthasePRO_0000409244Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE6ZZ11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 255241Lycopene beta-cyclaseAdd
BLAST
Regioni262 – 685424Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE6ZZ11.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 2 hits.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6ZZ11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLYQPSQD WPACTLSYRH FHLLWTLPLC AVLFLVARPF LTKLDRAKLI
60 70 80 90 100
LLPIIAFVWT TPWDNLIVKN RAWFYHRHCI WFTIGYVPIE EYFFFVIQSL
110 120 130 140 150
ISTLWCTLLT RWALPNLYLV PSSPKRRRLA TPAVVVCMLC FVLGLKAAVP
160 170 180 190 200
ETHSYYFGMI TWWSSLPLAL LLWGSVDFVS NMGVRAGLAP FALSVLAPTF
210 220 230 240 250
YLWASDVYAL RRGTWHINEA TSLNVFPIPH LPIEEMLFFL VTNLILVSAC
260 270 280 290 300
FTFDRCVAIC RQSVAENAPP LSPSYLPLGS LDTYTKLWAA FVRSDRPPVA
310 320 330 340 350
TSAASASVEP RDLAASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR
360 370 380 390 400
VADDLVDDDA QGLEAKSSNL DVIRAIVDAI YADSPEAAPQ KQPSAQPVSD
410 420 430 440 450
RIRTLLAPVA LPDKVKQDTR AAAASIAPLT RYIPKRLWYE MLQGYSLDLL
460 470 480 490 500
FEHPDADKRT RLRTMDDLVE YSQCVAGVVG EMCTRVILGR CGGAVPLELK
510 520 530 540 550
VDRTIAVPST KAAMAGKALD LTRADDVHAL LYEARRMGVS LQLVNIARDI
560 570 580 590 600
VPDSVELRRC YLPTDMFDKQ DARMQDALLA GHIAVRSQHT TTLEEKELVQ
610 620 630 640 650
PRDVRKYALR LLRVSRGLYD QAYPALAQIP NRPARAGLKA ACSVYAAIGT
660 670 680
RIEAQTETDV AEGRRARMSN RDRMLRAVSA VYFGV
Length:685
Mass (Da):76,702
Last modified:March 8, 2011 - v1
Checksum:i49081DA21E496E02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ311463 Genomic DNA. Translation: CBQ72468.1.

Genome annotation databases

EnsemblFungiiCBQ72468; CBQ72468; sr13176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ311463 Genomic DNA. Translation: CBQ72468.1.

3D structure databases

ProteinModelPortaliE6ZZ11.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCBQ72468; CBQ72468; sr13176.

Phylogenomic databases

InParanoidiE6ZZ11.
OrthoDBiEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3Di1.10.600.10. 2 hits.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SRZ2.

Entry informationi

Entry nameiLCPS_SPORE
AccessioniPrimary (citable) accession number: E6ZZ11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 8, 2011
Last modified: April 1, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.