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E6ZZ11

- LCPS_SPORE

UniProt

E6ZZ11 - LCPS_SPORE

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

sr13176

Organism
Sporisorium reilianum (strain SRZ2) (Maize head smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    ORF Names:sr13176
    OrganismiSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
    Taxonomic identifieri999809 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeSporisorium
    ProteomesiUP000008867: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 685685Bifunctional lycopene cyclase/phytoene synthasePRO_0000409244Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliE6ZZ11.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 255241Lycopene beta-cyclaseAdd
    BLAST
    Regioni262 – 685424Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7RBZJ2.

    Family and domain databases

    Gene3Di1.10.600.10. 2 hits.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 3 hits.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6ZZ11-1 [UniParc]FASTAAdd to Basket

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    MTRLYQPSQD WPACTLSYRH FHLLWTLPLC AVLFLVARPF LTKLDRAKLI    50
    LLPIIAFVWT TPWDNLIVKN RAWFYHRHCI WFTIGYVPIE EYFFFVIQSL 100
    ISTLWCTLLT RWALPNLYLV PSSPKRRRLA TPAVVVCMLC FVLGLKAAVP 150
    ETHSYYFGMI TWWSSLPLAL LLWGSVDFVS NMGVRAGLAP FALSVLAPTF 200
    YLWASDVYAL RRGTWHINEA TSLNVFPIPH LPIEEMLFFL VTNLILVSAC 250
    FTFDRCVAIC RQSVAENAPP LSPSYLPLGS LDTYTKLWAA FVRSDRPPVA 300
    TSAASASVEP RDLAASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR 350
    VADDLVDDDA QGLEAKSSNL DVIRAIVDAI YADSPEAAPQ KQPSAQPVSD 400
    RIRTLLAPVA LPDKVKQDTR AAAASIAPLT RYIPKRLWYE MLQGYSLDLL 450
    FEHPDADKRT RLRTMDDLVE YSQCVAGVVG EMCTRVILGR CGGAVPLELK 500
    VDRTIAVPST KAAMAGKALD LTRADDVHAL LYEARRMGVS LQLVNIARDI 550
    VPDSVELRRC YLPTDMFDKQ DARMQDALLA GHIAVRSQHT TTLEEKELVQ 600
    PRDVRKYALR LLRVSRGLYD QAYPALAQIP NRPARAGLKA ACSVYAAIGT 650
    RIEAQTETDV AEGRRARMSN RDRMLRAVSA VYFGV 685
    Length:685
    Mass (Da):76,702
    Last modified:March 8, 2011 - v1
    Checksum:i49081DA21E496E02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ311463 Genomic DNA. Translation: CBQ72468.1.

    Genome annotation databases

    EnsemblFungiiCBQ72468; CBQ72468; sr13176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ311463 Genomic DNA. Translation: CBQ72468.1 .

    3D structure databases

    ProteinModelPortali E6ZZ11.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CBQ72468 ; CBQ72468 ; sr13176 .

    Phylogenomic databases

    OrthoDBi EOG7RBZJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 2 hits.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 3 hits.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SRZ2.

    Entry informationi

    Entry nameiLCPS_SPORE
    AccessioniPrimary (citable) accession number: E6ZZ11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3