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E6ZZ11

- LCPS_SPORE

UniProt

E6ZZ11 - LCPS_SPORE

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene
sr13176
Organism
Sporisorium reilianum (strain SRZ2) (Maize head smut fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:sr13176
OrganismiSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
Taxonomic identifieri999809 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeSporisorium
ProteomesiUP000008867: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Transmembranei48 – 6821Helical; Reviewed predictionAdd
BLAST
Transmembranei92 – 11423Helical; Reviewed predictionAdd
BLAST
Transmembranei129 – 14921Helical; Reviewed predictionAdd
BLAST
Transmembranei156 – 17621Helical; Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Transmembranei231 – 25121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Bifunctional lycopene cyclase/phytoene synthasePRO_0000409244Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE6ZZ11.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 255241Lycopene beta-cyclaseAdd
BLAST
Regioni262 – 685424Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 2 hits.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6ZZ11-1 [UniParc]FASTAAdd to Basket

« Hide

MTRLYQPSQD WPACTLSYRH FHLLWTLPLC AVLFLVARPF LTKLDRAKLI    50
LLPIIAFVWT TPWDNLIVKN RAWFYHRHCI WFTIGYVPIE EYFFFVIQSL 100
ISTLWCTLLT RWALPNLYLV PSSPKRRRLA TPAVVVCMLC FVLGLKAAVP 150
ETHSYYFGMI TWWSSLPLAL LLWGSVDFVS NMGVRAGLAP FALSVLAPTF 200
YLWASDVYAL RRGTWHINEA TSLNVFPIPH LPIEEMLFFL VTNLILVSAC 250
FTFDRCVAIC RQSVAENAPP LSPSYLPLGS LDTYTKLWAA FVRSDRPPVA 300
TSAASASVEP RDLAASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR 350
VADDLVDDDA QGLEAKSSNL DVIRAIVDAI YADSPEAAPQ KQPSAQPVSD 400
RIRTLLAPVA LPDKVKQDTR AAAASIAPLT RYIPKRLWYE MLQGYSLDLL 450
FEHPDADKRT RLRTMDDLVE YSQCVAGVVG EMCTRVILGR CGGAVPLELK 500
VDRTIAVPST KAAMAGKALD LTRADDVHAL LYEARRMGVS LQLVNIARDI 550
VPDSVELRRC YLPTDMFDKQ DARMQDALLA GHIAVRSQHT TTLEEKELVQ 600
PRDVRKYALR LLRVSRGLYD QAYPALAQIP NRPARAGLKA ACSVYAAIGT 650
RIEAQTETDV AEGRRARMSN RDRMLRAVSA VYFGV 685
Length:685
Mass (Da):76,702
Last modified:March 8, 2011 - v1
Checksum:i49081DA21E496E02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ311463 Genomic DNA. Translation: CBQ72468.1.

Genome annotation databases

EnsemblFungiiCBQ72468; CBQ72468; sr13176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ311463 Genomic DNA. Translation: CBQ72468.1 .

3D structure databases

ProteinModelPortali E6ZZ11.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CBQ72468 ; CBQ72468 ; sr13176 .

Phylogenomic databases

OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 2 hits.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 3 hits.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SRZ2.

Entry informationi

Entry nameiLCPS_SPORE
AccessioniPrimary (citable) accession number: E6ZZ11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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