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E6ZZ11 (LCPS_SPORE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:sr13176
OrganismSporisorium reilianum (strain SRZ2) (Maize head smut fungus) [Complete proteome]
Taxonomic identifier999809 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeSporisorium

Protein attributes

Sequence length685 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 685685Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409244

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane92 – 11423Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane231 – 25121Helical; Potential
Region15 – 255241Lycopene beta-cyclase
Region262 – 685424Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
E6ZZ11 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 49081DA21E496E02

FASTA68576,702
        10         20         30         40         50         60 
MTRLYQPSQD WPACTLSYRH FHLLWTLPLC AVLFLVARPF LTKLDRAKLI LLPIIAFVWT 

        70         80         90        100        110        120 
TPWDNLIVKN RAWFYHRHCI WFTIGYVPIE EYFFFVIQSL ISTLWCTLLT RWALPNLYLV 

       130        140        150        160        170        180 
PSSPKRRRLA TPAVVVCMLC FVLGLKAAVP ETHSYYFGMI TWWSSLPLAL LLWGSVDFVS 

       190        200        210        220        230        240 
NMGVRAGLAP FALSVLAPTF YLWASDVYAL RRGTWHINEA TSLNVFPIPH LPIEEMLFFL 

       250        260        270        280        290        300 
VTNLILVSAC FTFDRCVAIC RQSVAENAPP LSPSYLPLGS LDTYTKLWAA FVRSDRPPVA 

       310        320        330        340        350        360 
TSAASASVEP RDLAASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR VADDLVDDDA 

       370        380        390        400        410        420 
QGLEAKSSNL DVIRAIVDAI YADSPEAAPQ KQPSAQPVSD RIRTLLAPVA LPDKVKQDTR 

       430        440        450        460        470        480 
AAAASIAPLT RYIPKRLWYE MLQGYSLDLL FEHPDADKRT RLRTMDDLVE YSQCVAGVVG 

       490        500        510        520        530        540 
EMCTRVILGR CGGAVPLELK VDRTIAVPST KAAMAGKALD LTRADDVHAL LYEARRMGVS 

       550        560        570        580        590        600 
LQLVNIARDI VPDSVELRRC YLPTDMFDKQ DARMQDALLA GHIAVRSQHT TTLEEKELVQ 

       610        620        630        640        650        660 
PRDVRKYALR LLRVSRGLYD QAYPALAQIP NRPARAGLKA ACSVYAAIGT RIEAQTETDV 

       670        680 
AEGRRARMSN RDRMLRAVSA VYFGV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ311463 Genomic DNA. Translation: CBQ72468.1.

3D structure databases

ProteinModelPortalE6ZZ11.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCBQ72468; CBQ72468; sr13176.

Phylogenomic databases

OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 2 hits.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 3 hits.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_SPORE
AccessionPrimary (citable) accession number: E6ZZ11
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways