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Protein

Alanine racemase

Gene

Nitsa_0213

Organism
Nitratifractor salsuginis (strain DSM 16511 / JCM 12458 / E9I37-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Active sitei243 – 2431Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei289 – 2891Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNSAL749222:GHWN-227-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Nitsa_0213Imported
OrganismiNitratifractor salsuginis (strain DSM 16511 / JCM 12458 / E9I37-1)Imported
Taxonomic identifieri749222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesNitratifractor
ProteomesiUP000008633 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6WZ35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6WZ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYILIDRGN FYHNLNQLAL KAGSKDRLAV VLKDNAYGHG LRLMGELSRD
60 70 80 90 100
YGIREAVVVT NDEADQISDL FDHILVLGDS PRPSSRCSYA VSEIGLLRWI
110 120 130 140 150
EPGVLIELKV DTGMHRNGIE PERLEEALEI IRKRKLRLFG VITHYRSADE
160 170 180 190 200
LTSEYFWQKK RFDEVKKRVI DAGFSETRFH SHNSAALLRC RNFDEDIARV
210 220 230 240 250
GIAIYGYNTL PKGFEGVELK PVLSLWARRA STRRLQEGAR IGYGGEFTAD
260 270 280 290 300
REMPVSTYDL GYGDGWPRGR ASEPYRTAEG KAILGRVSMD FISVEGEADR
310 320 330
ICVMEDARRA ARHFGTICYE MTTALMPTIP RRVVD
Length:335
Mass (Da):38,010
Last modified:March 8, 2011 - v1
Checksum:i82F0A385DE74D03D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002452 Genomic DNA. Translation: ADV45485.1.
RefSeqiYP_004167234.1. NC_014935.1.

Genome annotation databases

EnsemblBacteriaiADV45485; ADV45485; Nitsa_0213.
KEGGinsa:Nitsa_0213.
PATRICi46981949. VBINitSal150288_0214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002452 Genomic DNA. Translation: ADV45485.1.
RefSeqiYP_004167234.1. NC_014935.1.

3D structure databases

ProteinModelPortaliE6WZ35.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV45485; ADV45485; Nitsa_0213.
KEGGinsa:Nitsa_0213.
PATRICi46981949. VBINitSal150288_0214.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciNSAL749222:GHWN-227-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16511 / JCM 12458 / E9I37-1Imported.

Entry informationi

Entry nameiE6WZ35_NITSE
AccessioniPrimary (citable) accession number: E6WZ35
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 1, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.