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E6VUT5

- E6VUT5_DESAO

UniProt

E6VUT5 - E6VUT5_DESAO

Protein

Methylenetetrahydrofolate reductase

Gene

Daes_1312

Organism
Desulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

    Cofactori

    FAD.UniRule annotation
    FAD By similarity.

    Pathwayi

    GO - Molecular functioni

    1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid biosynthetic process Source: UniProtKB-KW
    2. methionine metabolic process Source: InterPro
    3. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesisUniRule annotation

    Keywords - Ligandi

    FADUniRule annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciDAES643562:GH9Z-1336-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
    Gene namesi
    Ordered Locus Names:Daes_1312Imported
    OrganismiDesulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2)Imported
    Taxonomic identifieri643562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002191: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE6VUT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246233.
    KOiK00297.

    Family and domain databases

    Gene3Di3.20.20.220. 1 hit.
    InterProiIPR029041. FAD-linked_oxidoreductase-like.
    IPR003171. Mehydrof_redctse.
    [Graphical view]
    PfamiPF02219. MTHFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF51730. SSF51730. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E6VUT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVCDLIEKN TPFISLEFFP PKEKDAWPGF FDVVEKLKDL GPLFASVTYG    50
    AGGGTQDNTL EIATRMKRDH GIEPIVHLTS VGASAAKLDT FLAGLSAAGL 100
    ENVLALRGDP PKGQEDFSFD SQEFKHATDV IEFISRRYPN ICVGGAAYPE 150
    SHPESPSIQS DLDMVNLKVR MGAKFLVTQL FFDNRLYFDY VARLRAMGAD 200
    VPVVPGVLPI MNLRSAKFIL GLCGAAIPGK YLSALEKANE EGGDEAVYAL 250
    GIRYAIRQAQ ELIDGGAPGV HLYTLNRAEA CLEIGKNLKI 290
    Length:290
    Mass (Da):31,563
    Last modified:March 8, 2011 - v1
    Checksum:i6575F576B92B3DF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002431 Genomic DNA. Translation: ADU62326.1.
    RefSeqiYP_004121072.1. NC_014844.1.

    Genome annotation databases

    EnsemblBacteriaiADU62326; ADU62326; Daes_1312.
    GeneIDi10095907.
    KEGGidas:Daes_1312.
    PATRICi45202625. VBIDesAes51796_1338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002431 Genomic DNA. Translation: ADU62326.1 .
    RefSeqi YP_004121072.1. NC_014844.1.

    3D structure databases

    ProteinModelPortali E6VUT5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU62326 ; ADU62326 ; Daes_1312 .
    GeneIDi 10095907.
    KEGGi das:Daes_1312.
    PATRICi 45202625. VBIDesAes51796_1338.

    Phylogenomic databases

    HOGENOMi HOG000246233.
    KOi K00297.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DAES643562:GH9Z-1336-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.220. 1 hit.
    InterProi IPR029041. FAD-linked_oxidoreductase-like.
    IPR003171. Mehydrof_redctse.
    [Graphical view ]
    Pfami PF02219. MTHFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51730. SSF51730. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Desulfovibrio aespoeensis Aspo-2."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pedersen K., Jagevall S., Hazen T., Woyke T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700646 / DSM 10631 / Aspo-2Imported.

    Entry informationi

    Entry nameiE6VUT5_DESAO
    AccessioniPrimary (citable) accession number: E6VUT5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3