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Protein

Methylenetetrahydrofolate reductase

Gene

Daes_1312

Organism
Pseudodesulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2) (Desulfovibrio aespoeensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesisUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciDAES643562:G1GPK-1333-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:Daes_1312Imported
OrganismiPseudodesulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2) (Desulfovibrio aespoeensis)Imported
Taxonomic identifieri643562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceae
Proteomesi
  • UP000002191 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi643562.Daes_1312

Structurei

3D structure databases

ProteinModelPortaliE6VUT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SYT Bacteria
COG0685 LUCA
HOGENOMiHOG000246233
KOiK00297
OrthoDBiPOG091H02HI

Family and domain databases

CDDicd00537 MTHFR, 1 hit
InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR003171 Mehydrof_redctse
PfamiView protein in Pfam
PF02219 MTHFR, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit

Sequencei

Sequence statusi: Complete.

E6VUT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVCDLIEKN TPFISLEFFP PKEKDAWPGF FDVVEKLKDL GPLFASVTYG
60 70 80 90 100
AGGGTQDNTL EIATRMKRDH GIEPIVHLTS VGASAAKLDT FLAGLSAAGL
110 120 130 140 150
ENVLALRGDP PKGQEDFSFD SQEFKHATDV IEFISRRYPN ICVGGAAYPE
160 170 180 190 200
SHPESPSIQS DLDMVNLKVR MGAKFLVTQL FFDNRLYFDY VARLRAMGAD
210 220 230 240 250
VPVVPGVLPI MNLRSAKFIL GLCGAAIPGK YLSALEKANE EGGDEAVYAL
260 270 280 290
GIRYAIRQAQ ELIDGGAPGV HLYTLNRAEA CLEIGKNLKI
Length:290
Mass (Da):31,563
Last modified:March 8, 2011 - v1
Checksum:i6575F576B92B3DF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002431 Genomic DNA Translation: ADU62326.1
RefSeqiWP_013514257.1, NC_014844.1

Genome annotation databases

EnsemblBacteriaiADU62326; ADU62326; Daes_1312
KEGGidas:Daes_1312

Similar proteinsi

Entry informationi

Entry nameiE6VUT5_PSEA9
AccessioniPrimary (citable) accession number: E6VUT5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 25, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health