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Protein

Methylenetetrahydrofolate reductase

Gene

Daes_1312

Organism
Desulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

GO - Molecular functioni

  1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid biosynthetic process Source: UniProtKB-KW
  2. methionine metabolic process Source: InterPro
  3. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesisUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciDAES643562:GH9Z-1336-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:Daes_1312Imported
OrganismiDesulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2)Imported
Taxonomic identifieri643562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002191: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE6VUT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246233.
KOiK00297.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.

Sequencei

Sequence statusi: Complete.

E6VUT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVCDLIEKN TPFISLEFFP PKEKDAWPGF FDVVEKLKDL GPLFASVTYG
60 70 80 90 100
AGGGTQDNTL EIATRMKRDH GIEPIVHLTS VGASAAKLDT FLAGLSAAGL
110 120 130 140 150
ENVLALRGDP PKGQEDFSFD SQEFKHATDV IEFISRRYPN ICVGGAAYPE
160 170 180 190 200
SHPESPSIQS DLDMVNLKVR MGAKFLVTQL FFDNRLYFDY VARLRAMGAD
210 220 230 240 250
VPVVPGVLPI MNLRSAKFIL GLCGAAIPGK YLSALEKANE EGGDEAVYAL
260 270 280 290
GIRYAIRQAQ ELIDGGAPGV HLYTLNRAEA CLEIGKNLKI
Length:290
Mass (Da):31,563
Last modified:March 8, 2011 - v1
Checksum:i6575F576B92B3DF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002431 Genomic DNA. Translation: ADU62326.1.
RefSeqiWP_013514257.1. NC_014844.1.
YP_004121072.1. NC_014844.1.

Genome annotation databases

EnsemblBacteriaiADU62326; ADU62326; Daes_1312.
GeneIDi10095907.
KEGGidas:Daes_1312.
PATRICi45202625. VBIDesAes51796_1338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002431 Genomic DNA. Translation: ADU62326.1.
RefSeqiWP_013514257.1. NC_014844.1.
YP_004121072.1. NC_014844.1.

3D structure databases

ProteinModelPortaliE6VUT5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU62326; ADU62326; Daes_1312.
GeneIDi10095907.
KEGGidas:Daes_1312.
PATRICi45202625. VBIDesAes51796_1338.

Phylogenomic databases

HOGENOMiHOG000246233.
KOiK00297.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciDAES643562:GH9Z-1336-MONOMER.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Desulfovibrio aespoeensis Aspo-2."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pedersen K., Jagevall S., Hazen T., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700646 / DSM 10631 / Aspo-2Imported.

Entry informationi

Entry nameiE6VUT5_DESAO
AccessioniPrimary (citable) accession number: E6VUT5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.