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E6VTC3 (E6VTC3_DESAO) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Daes_2276 EMBL ADU63282.1
OrganismDesulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2) [Complete proteome] [HAMAP] EMBL ADU63282.1
Taxonomic identifier643562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 296197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding127 – 18054ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2501Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2631Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2651Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E6VTC3 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: CF2C7E67E9B13E1D

FASTA30432,325
        10         20         30         40         50         60 
MHVILIAGGW SDEREVSLSG AKKIRTALEE LGHRVTFFDP AQDFRHLVRT AREADFAFIN 

        70         80         90        100        110        120 
LHGTPGEDGL IQAMLDKAGC PYQGAGAAAS YLALDKGASK EVFETLGIDT PPWQFITPTQ 

       130        140        150        160        170        180 
GADTPLALPL PVFVKPNKGG SSLGMSLVRT AGEFPSALSK VFAMCQSALV EIFIPGVELT 

       190        200        210        220        230        240 
CAVLGDRPLP LIMITPKAGA PFFDYENKYA ADGAEEVCPA PVSDAVTRLV QERMLAAHNA 

       250        260        270        280        290        300 
LGLTGYSRGD FILAADGTPY LLEINTLPGM TPTSLLPRAA GQVGLSFAAL ISELIRLGLE 


ERGR 

« Hide

References

[1]"Complete sequence of Desulfovibrio aespoeensis Aspo-2."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pedersen K., Jagevall S., Hazen T., Woyke T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700646 / DSM 10631 / Aspo-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002431 Genomic DNA. Translation: ADU63282.1.
RefSeqYP_004122028.1. NC_014844.1.

3D structure databases

ProteinModelPortalE6VTC3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU63282; ADU63282; Daes_2276.
GeneID10096900.
KEGGdas:Daes_2276.
PATRIC45204631. VBIDesAes51796_2311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycDAES643562:GH9Z-2329-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6VTC3_DESAO
AccessionPrimary (citable) accession number: E6VTC3
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)