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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Rhodopseudomonas palustris (strain DX-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotationSAAS annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108MagnesiumUniRule annotation1
Binding sitei111XanthineUniRule annotation1
Binding sitei154Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPurine salvageUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRPAL652103:G1GPO-3327-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:Rpdx1_3341Imported
OrganismiRhodopseudomonas palustris (strain DX-1)Imported
Taxonomic identifieri652103 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001402 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi652103.Rpdx1_3341.

Structurei

3D structure databases

ProteinModelPortaliE6VQC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 164PribosyltranInterPro annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 495-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni111 – 1155-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DYA. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000226805.
KOiK00769.
OMAiFHRDCRA.
OrthoDBiPOG091H03MJ.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01903. XGPRT. 1 hit.
InterProiView protein in InterPro
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
PANTHERiPTHR39563. PTHR39563. 1 hit.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

E6VQC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSEPSEQK RAGRPFPVSW DQFHRDCRAL SWRLNELGPF HAVIAITRGG
60 70 80 90 100
LVPAAIVARE LGLRVIDTVC IASYEHDKQG ELQVLKGVSD QTAALGGGTG
110 120 130 140 150
KGLLIIDDLV DTGKTGRMVR SLLPDAHFAA VYAKPKGRPL VDTFITEVSQ
160 170
DTWIFFPWDT GLSFQPPLKD GAA
Length:173
Mass (Da):18,869
Last modified:March 8, 2011 - v1
Checksum:i88E08260B5559CDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002418 Genomic DNA. Translation: ADU44912.1.
RefSeqiWP_013503028.1. NC_014834.1.

Genome annotation databases

EnsemblBacteriaiADU44912; ADU44912; Rpdx1_3341.
KEGGirpx:Rpdx1_3341.

Similar proteinsi

Entry informationi

Entry nameiE6VQC2_RHOPX
AccessioniPrimary (citable) accession number: E6VQC2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported