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E6VIC3

- E6VIC3_RHOPX

UniProt

E6VIC3 - E6VIC3_RHOPX

Protein

Isocitrate dehydrogenase [NADP]

Gene

Rpdx1_1511

Organism
Rhodopseudomonas palustris (strain DX-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysis
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRPAL652103:GHQR-1526-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Rpdx1_1511Imported
    OrganismiRhodopseudomonas palustris (strain DX-1)Imported
    Taxonomic identifieri652103 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001402: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6VIC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVKNPV VELDGDEMTR IIWQMIKDKL ITPFLDIELM YFDLGMEHRD    50
    ATDDQVTIDA ANAIKQVGVG VKCATITPDE ARVKEFGLKS MWKSPNGTIR 100
    NILGGVIFRE PIICKNVPRL VPGWTKPIVI GRHAYGDQYR ATDIKFPGPG 150
    TLTMKFVGED GSVIEREVFK APGAGVAMSM YNLDESIKDF ARASLNYGLI 200
    RNYPVYLSTK NTIMKVYDGR FKDIFQEIFD NEFKAEYDAK GLTYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLMTPDGKT 300
    VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTRGLAH RAKLDSNEEL 350
    ARFADTLEKV CVETVEAGAM TKDLALLVGA DQRWLSTEGF LDKVAQNLHK 400
    AMSETKAA 408
    Length:408
    Mass (Da):45,362
    Last modified:March 8, 2011 - v1
    Checksum:i336146B8EDC445D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002418 Genomic DNA. Translation: ADU43132.1.
    RefSeqiYP_004107865.1. NC_014834.1.

    Genome annotation databases

    EnsemblBacteriaiADU43132; ADU43132; Rpdx1_1511.
    GeneIDi10063712.
    KEGGirpx:Rpdx1_1511.
    PATRICi45343292. VBIRhoPal82507_1543.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002418 Genomic DNA. Translation: ADU43132.1 .
    RefSeqi YP_004107865.1. NC_014834.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU43132 ; ADU43132 ; Rpdx1_1511 .
    GeneIDi 10063712.
    KEGGi rpx:Rpdx1_1511.
    PATRICi 45343292. VBIRhoPal82507_1543.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci RPAL652103:GHQR-1526-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Rhodopseudomonas palustris DX-1."
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Misra M., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Logan B., Oda Y., Harwood C., Woyke T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DX-1Imported.

    Entry informationi

    Entry nameiE6VIC3_RHOPX
    AccessioniPrimary (citable) accession number: E6VIC3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3