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E6VIC3

- E6VIC3_RHOPX

UniProt

E6VIC3 - E6VIC3_RHOPX

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Rpdx1_1511
Organism
Rhodopseudomonas palustris (strain DX-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRPAL652103:GHQR-1526-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Rpdx1_1511Imported
OrganismiRhodopseudomonas palustris (strain DX-1)Imported
Taxonomic identifieri652103 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001402: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6VIC3-1 [UniParc]FASTAAdd to Basket

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MAKIKVKNPV VELDGDEMTR IIWQMIKDKL ITPFLDIELM YFDLGMEHRD    50
ATDDQVTIDA ANAIKQVGVG VKCATITPDE ARVKEFGLKS MWKSPNGTIR 100
NILGGVIFRE PIICKNVPRL VPGWTKPIVI GRHAYGDQYR ATDIKFPGPG 150
TLTMKFVGED GSVIEREVFK APGAGVAMSM YNLDESIKDF ARASLNYGLI 200
RNYPVYLSTK NTIMKVYDGR FKDIFQEIFD NEFKAEYDAK GLTYEHRLID 250
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLMTPDGKT 300
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTRGLAH RAKLDSNEEL 350
ARFADTLEKV CVETVEAGAM TKDLALLVGA DQRWLSTEGF LDKVAQNLHK 400
AMSETKAA 408
Length:408
Mass (Da):45,362
Last modified:March 8, 2011 - v1
Checksum:i336146B8EDC445D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002418 Genomic DNA. Translation: ADU43132.1.
RefSeqiYP_004107865.1. NC_014834.1.

Genome annotation databases

EnsemblBacteriaiADU43132; ADU43132; Rpdx1_1511.
GeneIDi10063712.
KEGGirpx:Rpdx1_1511.
PATRICi45343292. VBIRhoPal82507_1543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002418 Genomic DNA. Translation: ADU43132.1 .
RefSeqi YP_004107865.1. NC_014834.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU43132 ; ADU43132 ; Rpdx1_1511 .
GeneIDi 10063712.
KEGGi rpx:Rpdx1_1511.
PATRICi 45343292. VBIRhoPal82507_1543.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.

Enzyme and pathway databases

BioCyci RPAL652103:GHQR-1526-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Rhodopseudomonas palustris DX-1."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Misra M., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Logan B., Oda Y., Harwood C., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DX-1.

Entry informationi

Entry nameiE6VIC3_RHOPX
AccessioniPrimary (citable) accession number: E6VIC3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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