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Protein

Ribulose bisphosphate carboxylase

Gene

cbbM

Organism
Rhodopseudomonas palustris (strain DX-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112Substrate; in homodimeric partnerUniRule annotation1
Active sitei167Proton acceptorUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Metal bindingi192Magnesium; via carbamate groupUniRule annotation1
Metal bindingi194MagnesiumUniRule annotation1
Metal bindingi195MagnesiumUniRule annotation1
Active sitei288Proton acceptorUniRule annotation1
Binding sitei289SubstrateUniRule annotation1
Binding sitei322SubstrateUniRule annotation1
Sitei330Transition state stabilizerUniRule annotation1
Binding sitei369SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:cbbMUniRule annotation
Ordered Locus Names:Rpdx1_4819Imported
OrganismiRhodopseudomonas palustris (strain DX-1)Imported
Taxonomic identifieri652103 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001402 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi652103.Rpdx1_4819.

Structurei

3D structure databases

ProteinModelPortaliE6VEW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 133RuBisCO_large_NInterPro annotationAdd BLAST122
Domaini144 – 441RuBisCO_largeInterPro annotationAdd BLAST298

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1. Bacteria.
COG1850. LUCA.
HOGENOMiHOG000230831.
KOiK01601.
OMAiTARRQYP.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08211. RuBisCO_large_II. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01339. RuBisCO_L_type2. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020871. RuBisCO_lsuII.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6VEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNRYANL NLKESELIAG GRHVLCAYIM KPKAGFGNFI QTAAHFAAES
60 70 80 90 100
STGTNVEVST TDDFTRGVDA LVYEIDEAKS LMKIAYPIEL FDRNVIDGRA
110 120 130 140 150
MIASFLTLTI GNNQGMGDVE YAKMYDFYVP PAYLKLFDGP STTIKDLWRV
160 170 180 190 200
LGRPVINGGF IVGTIIKPKL GLRPQPFANA CYDFWLGGDF IKNDEPQGNQ
210 220 230 240 250
VFAPFKDTVR AVSEAMRRAQ DKTGEAKLFS FNITADDHYE MLARGEFILE
260 270 280 290 300
TFADNADHVA FLVDGYVAGP AAVTTARRAF PKQYLHYHRA GHGAVTSPQS
310 320 330 340 350
QRGYTAFVLS KMSRLQGASG IHVGTMGFGK MEGEASDRAA AFMITEDAAD
360 370 380 390 400
GPYFHQEWLG MNPTTPIISG GMNALRMPGF FDNLGHSNLI MTAGGGAFGH
410 420 430 440 450
VDGGAAGAKS LRQAEQCWKQ GADPVEFAKD HREFARAFES FPQDADKLYP
460
NWRAKLKPQA A
Length:461
Mass (Da):50,501
Last modified:March 8, 2011 - v1
Checksum:i38237BEBAF71147C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002418 Genomic DNA. Translation: ADU46363.1.
RefSeqiWP_013504455.1. NC_014834.1.

Genome annotation databases

EnsemblBacteriaiADU46363; ADU46363; Rpdx1_4819.
KEGGirpx:Rpdx1_4819.
PATRICi45350189. VBIRhoPal82507_4918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002418 Genomic DNA. Translation: ADU46363.1.
RefSeqiWP_013504455.1. NC_014834.1.

3D structure databases

ProteinModelPortaliE6VEW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi652103.Rpdx1_4819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU46363; ADU46363; Rpdx1_4819.
KEGGirpx:Rpdx1_4819.
PATRICi45350189. VBIRhoPal82507_4918.

Phylogenomic databases

eggNOGiENOG4105DT1. Bacteria.
COG1850. LUCA.
HOGENOMiHOG000230831.
KOiK01601.
OMAiTARRQYP.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08211. RuBisCO_large_II. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01339. RuBisCO_L_type2. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020871. RuBisCO_lsuII.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE6VEW0_RHOPX
AccessioniPrimary (citable) accession number: E6VEW0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.