ID   E6VAU5_VARPE            Unreviewed;       410 AA.
AC   E6VAU5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   OrderedLocusNames=Varpa_2092 {ECO:0000313|EMBL:ADU36299.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU36299.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU36299.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU36299.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT   paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-e00813(2013).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP002417; ADU36299.1; -; Genomic_DNA.
DR   RefSeq; WP_013540534.1; NC_014931.1.
DR   AlphaFoldDB; E6VAU5; -.
DR   STRING; 595537.Varpa_2092; -.
DR   KEGG; vpe:Varpa_2092; -.
DR   eggNOG; COG0436; Bacteria.
DR   HOGENOM; CLU_017584_4_2_4; -.
DR   OrthoDB; 9803354at2; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ADU36299.1};
KW   Transferase {ECO:0000313|EMBL:ADU36299.1}.
FT   DOMAIN          34..395
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   410 AA;  45353 MW;  76E7829B3E77A4A1 CRC64;
     MKQLKKSAKL ANVLYDIRGP IMDAAKQMED DGQKIIKLNI GNLAVFGFDA PEEIQQDMIR
     NLPNSAGYSD SKGVFAARKA VMHETQKQGI AGVTLDDIYL GNGASELIAM STNALLDDGD
     ELLLPAPDYP LWTASTSLSG GTPVHYLCDE ANGWMPNLAD IRAKITPRTK GIVVINPNNP
     TGALYSDDLL KSIVAIAREH GLVIFADEVY DKVLYDGVKH TAIASLSTDV LTLTFNSLSK
     SYRSCGYRAG WVVVSGDKRA AQDYIEGLNM LSNMRLCANV PGQWAIQTAL GGYQSINDLV
     CDGGRLRRQR DLAYELITAI PGVTCVKPSA ALYMFPRLDP EVYPITDDRQ FFLELLKETR
     VMLVQGTGFN WATPDHFRIV FLPHEDDLRE AINRIAKFLE QYRLRRKTAS
//