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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Variovorax paradoxus (strain EPS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541UniRule annotation
Active sitei599 – 5991UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciVPAR595537:GHGJ-1525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Varpa_1512Imported
OrganismiVariovorax paradoxus (strain EPS)Imported
Taxonomic identifieri595537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000008917: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6V2K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKASKTPALP KRRQAEDQPL IDDIRLLGRI LGDVIREQEG DETYALVEKI
60 70 80 90 100
RTLSVAFRRD ADQAADRALK NLLKGLSAAE TVRVIRAFTY FSHLANLAED
110 120 130 140 150
RHQIRRRTEA DREGVLADGD LQTALARIRK AGVKPDEIVA SLAHSYVSPV
160 170 180 190 200
LTAHPTEVQR KSILDAERAI ALLLTTRDEI KLRQSAYASG KDALSPIELA
210 220 230 240 250
DNETQMRTRV TQIWQTRLLR FSKLTVADEI ENALSYYEAT FLREIPRVYA
260 270 280 290 300
DLEKALTQGG HTPSVAPFLR MGQWIGGDRD GNPNVTAETL EYALGRQAEL
310 320 330 340 350
ALRLYLTEVH YLGGELSLSA TLVDVSVEMQ ALAERSPDTS EHRKDEPYRR
360 370 380 390 400
ALTGVYARLA ATLRELTGGE AARHAVAPQN PYAKAEEFLA DLRTVEESLG
410 420 430 440 450
EKHGSVLAAP RLRPLIRAVE VFGFHLATVD LRQSSDKHEA VIAELLATAR
460 470 480 490 500
IEPSYASLAE EAKQTLLLKL LDDARPLRVP DADYSPLAKS ELAIFAAART
510 520 530 540 550
ARARYGAAAI RHYIISHTET VSDLLEALLL QKEVGLLRGA MATNAVCDLI
560 570 580 590 600
VVPLFETIED LRNAAPIVRA FYALPNIQAL IERSGGEQDV MLGYSDSNKD
610 620 630 640 650
GGIFTSNWEL YRAGIALVSL FDELNKKKAN PIRLRMFHGR GGTVGRGGGP
660 670 680 690 700
SYQAILAQPP GTVRGQIRLT EQGEVIGSKY ANREIGRRNL ETLVAATLEA
710 720 730 740 750
TLLPQGKSAP ATFLSAASEL SAASMAAYRK LVYETPGFGD YFFGSTPIRE
760 770 780 790 800
IAELNIGSRP ASRNPSHKID DLRAVPWSFS WGQCRLTIPG WFGFGAGVEQ
810 820 830 840 850
FLASAGNAAG KKERVALLQR MYAQWPFFRT LLSNMDMVLA KSDLALASRY
860 870 880 890 900
AELVTDRKLR QKVFSMIDAE WHRTSDALTL ITGAKQRLEG NAEMQRSVRH
910 920 930 940
RFPYIDPLHH LQVELMRRYR AGDGGERLQR GIHISINGVA AGLRNTG
Length:947
Mass (Da):104,659
Last modified:March 8, 2011 - v1
Checksum:i75A6A0E59497708E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002417 Genomic DNA. Translation: ADU35723.1.
RefSeqiWP_013539966.1. NC_014931.1.
YP_004153834.1. NC_014931.1.

Genome annotation databases

EnsemblBacteriaiADU35723; ADU35723; Varpa_1512.
GeneIDi10128333.
KEGGivpe:Varpa_1512.
PATRICi45389002. VBIVarPar156291_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002417 Genomic DNA. Translation: ADU35723.1.
RefSeqiWP_013539966.1. NC_014931.1.
YP_004153834.1. NC_014931.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU35723; ADU35723; Varpa_1512.
GeneIDi10128333.
KEGGivpe:Varpa_1512.
PATRICi45389002. VBIVarPar156291_1554.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Enzyme and pathway databases

BioCyciVPAR595537:GHGJ-1525-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Variovorax paradoxus EPS."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EPSImported.

Entry informationi

Entry nameiE6V2K2_VARPE
AccessioniPrimary (citable) accession number: E6V2K2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.