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Protein

Alanine racemase

Gene

Varpa_0233

Organism
Variovorax paradoxus (strain EPS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVPAR595537:GHGJ-239-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Varpa_0233Imported
OrganismiVariovorax paradoxus (strain EPS)Imported
Taxonomic identifieri595537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000008917: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6V191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiRDLELCS.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6V191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPILATVH TAALRNNLER VRRSALDARV WAVVKANAYG HGIERVYEGL
60 70 80 90 100
RGADGFALLD LAEAERVRAL GWRGPVLLLE GVFDARDLEL CSRLDLWHTV
110 120 130 140 150
HCDEQIDMLA AHKTLKPQRV FLKMNSGMNR LGFTPERFGS AWTRLNALTQ
160 170 180 190 200
VDEISLMTHF SDADGARGIA HQLEAFERAT RDLPGERSIA NSAATLRHAD
210 220 230 240 250
QTRGDWVRPG IVLYGSAPDF PLHDAAHWQL QPTMTLSTQL LSVQTLKAGD
260 270 280 290 300
TIGYGSNFTA EGPLTIGVAA VGYADGYPRH CNTGTPVLVN GVRTRMVGRV
310 320 330 340 350
SMDMITVDLT PVPDAKFGAE VTLWGRSAST GAVLPIDEVA QAAGTVGYEL
360
MCAVAQRVPF AAPTDE
Length:366
Mass (Da):39,803
Last modified:March 8, 2011 - v1
Checksum:iFD05A9EFAC4C17FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002417 Genomic DNA. Translation: ADU34455.1.
RefSeqiWP_013538701.1. NC_014931.1.
YP_004152566.1. NC_014931.1.

Genome annotation databases

EnsemblBacteriaiADU34455; ADU34455; Varpa_0233.
GeneIDi10127046.
KEGGivpe:Varpa_0233.
PATRICi45386341. VBIVarPar156291_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002417 Genomic DNA. Translation: ADU34455.1.
RefSeqiWP_013538701.1. NC_014931.1.
YP_004152566.1. NC_014931.1.

3D structure databases

ProteinModelPortaliE6V191.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU34455; ADU34455; Varpa_0233.
GeneIDi10127046.
KEGGivpe:Varpa_0233.
PATRICi45386341. VBIVarPar156291_0235.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiRDLELCS.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciVPAR595537:GHGJ-239-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Variovorax paradoxus EPS."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EPSImported.

Entry informationi

Entry nameiE6V191_VARPE
AccessioniPrimary (citable) accession number: E6V191
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.