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E6V191

- E6V191_VARPE

UniProt

E6V191 - E6V191_VARPE

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Protein

Alanine racemase

Gene
Varpa_0233
Organism
Variovorax paradoxus (strain EPS)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei130 – 1301Substrate By similarityUniRule annotation
Active sitei254 – 2541Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciVPAR595537:GHGJ-239-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Varpa_0233Imported
OrganismiVariovorax paradoxus (strain EPS)Imported
Taxonomic identifieri595537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000008917: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6V191.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiYGHGLER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6V191-1 [UniParc]FASTAAdd to Basket

« Hide

MPRPILATVH TAALRNNLER VRRSALDARV WAVVKANAYG HGIERVYEGL    50
RGADGFALLD LAEAERVRAL GWRGPVLLLE GVFDARDLEL CSRLDLWHTV 100
HCDEQIDMLA AHKTLKPQRV FLKMNSGMNR LGFTPERFGS AWTRLNALTQ 150
VDEISLMTHF SDADGARGIA HQLEAFERAT RDLPGERSIA NSAATLRHAD 200
QTRGDWVRPG IVLYGSAPDF PLHDAAHWQL QPTMTLSTQL LSVQTLKAGD 250
TIGYGSNFTA EGPLTIGVAA VGYADGYPRH CNTGTPVLVN GVRTRMVGRV 300
SMDMITVDLT PVPDAKFGAE VTLWGRSAST GAVLPIDEVA QAAGTVGYEL 350
MCAVAQRVPF AAPTDE 366
Length:366
Mass (Da):39,803
Last modified:March 8, 2011 - v1
Checksum:iFD05A9EFAC4C17FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002417 Genomic DNA. Translation: ADU34455.1.
RefSeqiYP_004152566.1. NC_014931.1.

Genome annotation databases

EnsemblBacteriaiADU34455; ADU34455; Varpa_0233.
GeneIDi10127046.
KEGGivpe:Varpa_0233.
PATRICi45386341. VBIVarPar156291_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002417 Genomic DNA. Translation: ADU34455.1 .
RefSeqi YP_004152566.1. NC_014931.1.

3D structure databases

ProteinModelPortali E6V191.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU34455 ; ADU34455 ; Varpa_0233 .
GeneIDi 10127046.
KEGGi vpe:Varpa_0233.
PATRICi 45386341. VBIVarPar156291_0235.

Phylogenomic databases

HOGENOMi HOG000031446.
KOi K01775.
OMAi YGHGLER.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci VPAR595537:GHGJ-239-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Variovorax paradoxus EPS."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EPS.

Entry informationi

Entry nameiE6V191_VARPE
AccessioniPrimary (citable) accession number: E6V191
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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