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E6URL9

- E6URL9_CLOTL

UniProt

E6URL9 - E6URL9_CLOTL

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Protein

Alanine racemase

Gene

Clo1313_0288

Organism
Clostridium thermocellum (strain DSM 1313 / LMG 6656 / LQ8) (Ruminiclostridium thermocellum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei318 – 3181Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCTHE637887:GLBN-299-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Clo1313_0288Imported
OrganismiClostridium thermocellum (strain DSM 1313 / LMG 6656 / LQ8) (Ruminiclostridium thermocellum)Imported
Taxonomic identifieri637887 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
ProteomesiUP000008083: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6URL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiRIGISIY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6URL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMDYKFNRA WAEVNLDNIA HNVKEIRRIV DKKVEIMGVV KADAYGHGVM
60 70 80 90 100
EIARTLLENG VTRLAVSMLD EAIQLRQNGI KVPILILSYT DPVRAEEIVL
110 120 130 140 150
NDVTQTVFSH DLAEALSEAA VKHHRNVKIH IKIDTGMTRV GFMPGYSAVK
160 170 180 190 200
NVVQISKLPG IIIEGLFTHF ASADEADKSY TYMQFERFMS IVGELNRIGV
210 220 230 240 250
YIPVKHVCNS AALIEFPEMH LNMVRPGIAL YGLYPSDEVD KTKIDLRPAM
260 270 280 290 300
SLKANVILVK DVEKDTFISY GRIFKTSRNS RIATIPIGYA DGYTRLLTGK
310 320 330 340 350
GKVLLNGQLA PIVGRICMDQ CMVDITDIEG DVKVGDEAVL IGKQKDNEIK
360 370 380 390
VEDLAKSVGT INYELVSIIG KRIPRVYLKE GKIYNVLNYL I
Length:391
Mass (Da):43,669
Last modified:March 8, 2011 - v1
Checksum:iE8D3E5C6DD62681E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002416 Genomic DNA. Translation: ADU73379.1.
RefSeqiYP_005686830.1. NC_017304.1.

Genome annotation databases

EnsemblBacteriaiADU73379; ADU73379; Clo1313_0288.
GeneIDi12419986.
KEGGictx:Clo1313_0288.
PATRICi45475120. VBICloThe140364_0315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002416 Genomic DNA. Translation: ADU73379.1 .
RefSeqi YP_005686830.1. NC_017304.1.

3D structure databases

ProteinModelPortali E6URL9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU73379 ; ADU73379 ; Clo1313_0288 .
GeneIDi 12419986.
KEGGi ctx:Clo1313_0288.
PATRICi 45475120. VBICloThe140364_0315.

Phylogenomic databases

KOi K01775.
OMAi RIGISIY.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CTHE637887:GLBN-299-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 1313 / LMG 6656 / LQ8Imported.

Entry informationi

Entry nameiE6URL9_CLOTL
AccessioniPrimary (citable) accession number: E6URL9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3