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Protein

Alanine racemase

Gene

Rumal_0238

Organism
Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei268 – 2681Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRALB697329:GIWQ-244-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Rumal_0238Imported
OrganismiRuminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7)Imported
Taxonomic identifieri697329 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus
ProteomesiUP000006919 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6UD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E6UD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLRRCWAE IDLSAVDYNV CEYKKLLPQD TELMCVVKAS CYGHSDELIV
60 70 80 90 100
PRLQQVHGVR YFAVSNILEG IRLREIGING DILILGYTPP ECAAELVKYD
110 120 130 140 150
IIQACTELCY AQELSANANG TVRLHGAVDT GMTRIGVHGT AEEQADELAK
160 170 180 190 200
VSALPNISLE GIFTHFSSAD GIDDADEKYT QMQSERFFRV RDLLKEKGIR
210 220 230 240 250
LKHAHIKNSA GGAYGYGDES TLARLGIILY GLYPDPAKSL PFVPKPVMTL
260 270 280 290 300
KAVVSQVKWI DEGTAVSYGR TFVSDRRMKL ATVTAGYADG YPRALSNKGE
310 320 330 340 350
VIIRGKKCRI CGRVCMDQFM CDVTDIPDAA PGDEVILMNA EINADVIAAL
360 370
TGTIGYEITC DITSRVPRVP VNS
Length:373
Mass (Da):40,970
Last modified:March 8, 2011 - v1
Checksum:i6EDD22E59419B162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002403 Genomic DNA. Translation: ADU20795.1.
RefSeqiWP_013496987.1. NZ_JHYT01000003.1.
YP_004103429.1. NC_014833.1.

Genome annotation databases

EnsemblBacteriaiADU20795; ADU20795; Rumal_0238.
KEGGiral:Rumal_0238.
PATRICi45356795. VBIRumAlb150544_0959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002403 Genomic DNA. Translation: ADU20795.1.
RefSeqiWP_013496987.1. NZ_JHYT01000003.1.
YP_004103429.1. NC_014833.1.

3D structure databases

ProteinModelPortaliE6UD01.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU20795; ADU20795; Rumal_0238.
KEGGiral:Rumal_0238.
PATRICi45356795. VBIRumAlb150544_0959.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRALB697329:GIWQ-244-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7Imported.

Entry informationi

Entry nameiE6UD01_RUMA7
AccessioniPrimary (citable) accession number: E6UD01
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 27, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.