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Protein

Alanine racemase

Gene

Rumal_0238

Organism
Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Rumal_0238)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Active sitei268Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei316Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Rumal_0238Imported
OrganismiRuminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7)Imported
Taxonomic identifieri697329 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus
Proteomesi
  • UP000006919 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi697329.Rumal_0238

Structurei

3D structure databases

ProteinModelPortaliE6UD01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 371Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

E6UD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLRRCWAE IDLSAVDYNV CEYKKLLPQD TELMCVVKAS CYGHSDELIV
60 70 80 90 100
PRLQQVHGVR YFAVSNILEG IRLREIGING DILILGYTPP ECAAELVKYD
110 120 130 140 150
IIQACTELCY AQELSANANG TVRLHGAVDT GMTRIGVHGT AEEQADELAK
160 170 180 190 200
VSALPNISLE GIFTHFSSAD GIDDADEKYT QMQSERFFRV RDLLKEKGIR
210 220 230 240 250
LKHAHIKNSA GGAYGYGDES TLARLGIILY GLYPDPAKSL PFVPKPVMTL
260 270 280 290 300
KAVVSQVKWI DEGTAVSYGR TFVSDRRMKL ATVTAGYADG YPRALSNKGE
310 320 330 340 350
VIIRGKKCRI CGRVCMDQFM CDVTDIPDAA PGDEVILMNA EINADVIAAL
360 370
TGTIGYEITC DITSRVPRVP VNS
Length:373
Mass (Da):40,970
Last modified:March 8, 2011 - v1
Checksum:i6EDD22E59419B162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002403 Genomic DNA Translation: ADU20795.1
RefSeqiWP_013496987.1, NZ_JHYT01000003.1

Genome annotation databases

EnsemblBacteriaiADU20795; ADU20795; Rumal_0238
KEGGiral:Rumal_0238

Similar proteinsi

Entry informationi

Entry nameiE6UD01_RUMA7
AccessioniPrimary (citable) accession number: E6UD01
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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