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Protein

Glutamate decarboxylase

Gene

Ethha_0732

Organism
Ethanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciEHAR663278:GIWT-750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:Ethha_0732Imported
OrganismiEthanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3)Imported
Taxonomic identifieri663278 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeEthanoligenens
ProteomesiUP000001551 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiHINRVAT.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E6U2L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHQNKNNEK LQKIHPANTL SLYDDVDIPK YTLRKQPIEP DVACRLIKNE
60 70 80 90 100
LLDEGNARLN LATFCSTFME DEAIRLMADT LEKNAIDKSE YPSTIELENR
110 120 130 140 150
CVNIIADLWH APENQFIGTS TVGSSEACML AGLAMKFRWR NRAQRLGLDI
160 170 180 190 200
CEKKPNLVIS SGYQVCWEKF CVYWDVELRA VPMDPEHLSL DVNAAIRAVD
210 220 230 240 250
AYTIGIVGIL GQTYTGKFDD IRLLDKAVGQ YNSQTEETVY IHVDAASGGL
260 270 280 290 300
FAPFSQPELE WDFRLENVVS INTSGHKYGL VYPGIGWVVW RDKTCLPKEL
310 320 330 340 350
IFEVNYLGGT MPTMAINFSR SASHIIGQYY NFLRLGYDGY CRVHRHTRKI
360 370 380 390 400
ADYLAENLDA TGLFALINRG DSIPVVCFTM KEQAADWTLY DLSDQLERNG
410 420 430 440 450
WQVPVYPLPN HAQNIIVCRL VCRSDMSLNL AQRLMEDIHL AIETLGRAHP
460
RADRAKRGDI KGFTH
Length:465
Mass (Da):52,801
Last modified:March 8, 2011 - v1
Checksum:i63A6B55839100641
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002400 Genomic DNA. Translation: ADU26301.1.
RefSeqiWP_013484671.1. NC_014828.1.
YP_004091032.1. NC_014828.1.

Genome annotation databases

EnsemblBacteriaiADU26301; ADU26301; Ethha_0732.
KEGGieha:Ethha_0732.
PATRICi45208516. VBIEthHar145175_0821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002400 Genomic DNA. Translation: ADU26301.1.
RefSeqiWP_013484671.1. NC_014828.1.
YP_004091032.1. NC_014828.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU26301; ADU26301; Ethha_0732.
KEGGieha:Ethha_0732.
PATRICi45208516. VBIEthHar145175_0821.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiHINRVAT.

Enzyme and pathway databases

BioCyciEHAR663278:GIWT-750-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Ethanoligenens harbinense YUAN-3."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.
    , Wang A., Mouttaki H., He Z., Zhou J., Hemme C.L., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3Imported.

Entry informationi

Entry nameiE6U2L0_ETHHY
AccessioniPrimary (citable) accession number: E6U2L0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 27, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.