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E6TSX6 (E6TSX6_BACCJ) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO HAMAP-Rule MF_01037

EC=2.1.1.74 HAMAP-Rule MF_01037
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase HAMAP-Rule MF_01037
Folate-dependent tRNA(M-5-U54)-methyltransferase HAMAP-Rule MF_01037
Gene names
Name:trmFO HAMAP-Rule MF_01037
Ordered Locus Names:Bcell_2511 EMBL ADU30768.1
OrganismBacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4) [Complete proteome] [HAMAP] EMBL ADU30768.1
Taxonomic identifier649639 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Catalytic activity

5,10-methylenetetrahydrofolate + uracil54 in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil54 in tRNA + FAD. HAMAP-Rule MF_01037 SAAS SAAS004417

Cofactor

FAD By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01037 SAAS SAAS004417.

Sequence similarities

Belongs to the MnmG family. TrmFO subfamily. HAMAP-Rule MF_01037

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 146FAD By similarity HAMAP-Rule MF_01037

Sequences

Sequence LengthMass (Da)Tools
E6TSX6 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 7D1F584A608BDA37

FASTA43448,678
        10         20         30         40         50         60 
MTQHVNVIGA GLAGSEAAWQ IAKRGIPVHL YEMRPKKQTP AHHTDKFAEL VCSNSLRANT 

        70         80         90        100        110        120 
LTNAVGVLKE EMRILDSVII QSADDCSVPA GGALAVDRHE FAALVTERVK NHELVTVFED 

       130        140        150        160        170        180 
EVTEIPEGPT IICTGPLTSE SLSHRLKELT GEEYLYFYDA AAPIIDADSI DRNKVYLKSR 

       190        200        210        220        230        240 
YDKGEAAYLN CPMTEEEFNT FYDALIEAET VPVKEFEKEM FFEGCMPVEV MAKRGRKTLL 

       250        260        270        280        290        300 
FGPMKPVGLE DPKTNKRPFA VVQLRQDNSS GTLFNIVGFQ THMKWGPQKE VIQLIPGLEN 

       310        320        330        340        350        360 
AEIVRFGVMH RNTFINSPNL LKPTYQYRDR DDLFFAGQMT GVEGYVESAA AGLVAGINAS 

       370        380        390        400        410        420 
RLIQEKETVT FPNETVIGSM AQYITTANHK NFQPMNANFG LLPPFEQRIK NKQERNEKHA 

       430 
NRALETIQNF VKKM 

« Hide

References

[1]"Complete sequence of Bacillus cellulosilyticus DSM 2522."
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Brumm P., Mead D., Woyke T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002394 Genomic DNA. Translation: ADU30768.1.
RefSeqYP_004095499.1. NC_014829.1.

3D structure databases

ProteinModelPortalE6TSX6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU30768; ADU30768; Bcell_2511.
GeneID10089084.
KEGGbco:Bcell_2511.
PATRIC45161012. VBIBacCel7049_2580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000252054.
KOK04094.

Enzyme and pathway databases

BioCycBCEL649639:GHTT-2592-MONOMER.

Family and domain databases

HAMAPMF_01037. TrmFO.
InterProIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00137. gid_trmFO. 1 hit.
PROSITEPS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6TSX6_BACCJ
AccessionPrimary (citable) accession number: E6TSX6
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)