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E6TSX6

- E6TSX6_BACCJ

UniProt

E6TSX6 - E6TSX6_BACCJ

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciBCEL649639:GHTT-2592-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:Bcell_2511Imported
    OrganismiBacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)Imported
    Taxonomic identifieri649639 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001401: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE6TSX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6TSX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQHVNVIGA GLAGSEAAWQ IAKRGIPVHL YEMRPKKQTP AHHTDKFAEL    50
    VCSNSLRANT LTNAVGVLKE EMRILDSVII QSADDCSVPA GGALAVDRHE 100
    FAALVTERVK NHELVTVFED EVTEIPEGPT IICTGPLTSE SLSHRLKELT 150
    GEEYLYFYDA AAPIIDADSI DRNKVYLKSR YDKGEAAYLN CPMTEEEFNT 200
    FYDALIEAET VPVKEFEKEM FFEGCMPVEV MAKRGRKTLL FGPMKPVGLE 250
    DPKTNKRPFA VVQLRQDNSS GTLFNIVGFQ THMKWGPQKE VIQLIPGLEN 300
    AEIVRFGVMH RNTFINSPNL LKPTYQYRDR DDLFFAGQMT GVEGYVESAA 350
    AGLVAGINAS RLIQEKETVT FPNETVIGSM AQYITTANHK NFQPMNANFG 400
    LLPPFEQRIK NKQERNEKHA NRALETIQNF VKKM 434
    Length:434
    Mass (Da):48,678
    Last modified:March 8, 2011 - v1
    Checksum:i7D1F584A608BDA37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002394 Genomic DNA. Translation: ADU30768.1.
    RefSeqiWP_013489102.1. NC_014829.1.
    YP_004095499.1. NC_014829.1.

    Genome annotation databases

    EnsemblBacteriaiADU30768; ADU30768; Bcell_2511.
    GeneIDi10089084.
    KEGGibco:Bcell_2511.
    PATRICi45161012. VBIBacCel7049_2580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002394 Genomic DNA. Translation: ADU30768.1 .
    RefSeqi WP_013489102.1. NC_014829.1.
    YP_004095499.1. NC_014829.1.

    3D structure databases

    ProteinModelPortali E6TSX6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU30768 ; ADU30768 ; Bcell_2511 .
    GeneIDi 10089084.
    KEGGi bco:Bcell_2511.
    PATRICi 45161012. VBIBacCel7049_2580.

    Phylogenomic databases

    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.

    Enzyme and pathway databases

    BioCyci BCEL649639:GHTT-2592-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Bacillus cellulosilyticus DSM 2522."
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Brumm P., Mead D., Woyke T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4Imported.

    Entry informationi

    Entry nameiE6TSX6_BACCJ
    AccessioniPrimary (citable) accession number: E6TSX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3