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E6TSX6

- E6TSX6_BACCJ

UniProt

E6TSX6 - E6TSX6_BACCJ

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Protein
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Gene
trmFO, Bcell_2511
Organism
Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotationSAAS annotations

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotations

Cofactori

FAD By similarity.UniRule annotationSAAS annotations

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FAD By similarityUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotations

    Keywords - Ligandi

    FADUniRule annotationSAAS annotations, Flavoprotein

    Enzyme and pathway databases

    BioCyciBCEL649639:GHTT-2592-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferase
    Folate-dependent tRNA(M-5-U54)-methyltransferase
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:Bcell_2511Imported
    OrganismiBacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)Imported
    Taxonomic identifieri649639 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001401: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotationSAAS annotations

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotations

    Structurei

    3D structure databases

    ProteinModelPortaliE6TSX6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6TSX6-1 [UniParc]FASTAAdd to Basket

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    MTQHVNVIGA GLAGSEAAWQ IAKRGIPVHL YEMRPKKQTP AHHTDKFAEL    50
    VCSNSLRANT LTNAVGVLKE EMRILDSVII QSADDCSVPA GGALAVDRHE 100
    FAALVTERVK NHELVTVFED EVTEIPEGPT IICTGPLTSE SLSHRLKELT 150
    GEEYLYFYDA AAPIIDADSI DRNKVYLKSR YDKGEAAYLN CPMTEEEFNT 200
    FYDALIEAET VPVKEFEKEM FFEGCMPVEV MAKRGRKTLL FGPMKPVGLE 250
    DPKTNKRPFA VVQLRQDNSS GTLFNIVGFQ THMKWGPQKE VIQLIPGLEN 300
    AEIVRFGVMH RNTFINSPNL LKPTYQYRDR DDLFFAGQMT GVEGYVESAA 350
    AGLVAGINAS RLIQEKETVT FPNETVIGSM AQYITTANHK NFQPMNANFG 400
    LLPPFEQRIK NKQERNEKHA NRALETIQNF VKKM 434
    Length:434
    Mass (Da):48,678
    Last modified:March 8, 2011 - v1
    Checksum:i7D1F584A608BDA37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002394 Genomic DNA. Translation: ADU30768.1.
    RefSeqiWP_013489102.1. NC_014829.1.
    YP_004095499.1. NC_014829.1.

    Genome annotation databases

    EnsemblBacteriaiADU30768; ADU30768; Bcell_2511.
    GeneIDi10089084.
    KEGGibco:Bcell_2511.
    PATRICi45161012. VBIBacCel7049_2580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002394 Genomic DNA. Translation: ADU30768.1 .
    RefSeqi WP_013489102.1. NC_014829.1.
    YP_004095499.1. NC_014829.1.

    3D structure databases

    ProteinModelPortali E6TSX6.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU30768 ; ADU30768 ; Bcell_2511 .
    GeneIDi 10089084.
    KEGGi bco:Bcell_2511.
    PATRICi 45161012. VBIBacCel7049_2580.

    Phylogenomic databases

    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.

    Enzyme and pathway databases

    BioCyci BCEL649639:GHTT-2592-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Bacillus cellulosilyticus DSM 2522."
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Brumm P., Mead D., Woyke T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4.

    Entry informationi

    Entry nameiE6TSX6_BACCJ
    AccessioniPrimary (citable) accession number: E6TSX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: September 3, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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