Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate decarboxylase

Gene

Mspyr1_43520

Organism
Mycobacterium sp. (strain Spyr1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMSP278137:GHD6-4313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:Mspyr1_43520Imported
OrganismiMycobacterium sp. (strain Spyr1)Imported
Taxonomic identifieri278137 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000008916: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST

Structurei

3D structure databases

ProteinModelPortaliE6TDE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E6TDE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNVSRHSSL APAYTGRMSM SPVPALRLPD ESMEPEQAYR FIHDELMLDG
60 70 80 90 100
SSRLNLATFV TTWMDPEAGQ LMSETFDKNM IDKDEYPVTA AIEQRCVCMV
110 120 130 140 150
ADLFHAENLR DDDPSTAIGV STVGSSEAVM LAGLAMKWRW RDKFAGKDGD
160 170 180 190 200
GWKGRTPNLV MGSNVQVVWE KFCRYFDVEA RYLPMEKGRY VITPEQVLDA
210 220 230 240 250
VDEDTIGVVA ILGTTFTGEL EPVAEICAAL DALAAGGGCD VPVHVDAASG
260 270 280 290 300
GFVVPFLNPL LVWDFRLPRV VSINVSGHKY GLTYPGIGFV VWRNAEHLPE
310 320 330 340 350
DLVFRVNYLG GDMPTFTLNF SRPGNQVVGQ YYNFLRLGRD GYTQVMHALA
360 370 380 390 400
DTAQWLAREL EGMTGSDHKP VFEVITDGSA IPVVAFRLTE GAKFTVFDIS
410 420 430 440 450
ALLRSYGWQV PAYTMPEDAT DIAVLRIVVR EGFSANLARA LRDDLREVLG
460
KLDKVGIGGF SDEEHFAH
Length:468
Mass (Da):51,707
Last modified:March 8, 2011 - v1
Checksum:iF8B73400E0062D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA. Translation: ADU00909.1.
RefSeqiYP_004078743.1. NC_014814.1.

Genome annotation databases

EnsemblBacteriaiADU00909; ADU00909; Mspyr1_43520.
GeneIDi10048741.
KEGGimsp:Mspyr1_43520.
PATRICi45289909. VBIMycSp109077_4578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA. Translation: ADU00909.1.
RefSeqiYP_004078743.1. NC_014814.1.

3D structure databases

ProteinModelPortaliE6TDE0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU00909; ADU00909; Mspyr1_43520.
GeneIDi10048741.
KEGGimsp:Mspyr1_43520.
PATRICi45289909. VBIMycSp109077_4578.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Enzyme and pathway databases

BioCyciMSP278137:GHD6-4313-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Mycobacterium sp. Spyr1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L., Koukkou A.I., Drainas C., Kyrpides N., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Spyr1Imported.

Entry informationi

Entry nameiE6TDE0_MYCSR
AccessioniPrimary (citable) accession number: E6TDE0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.