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E6TD23 (E6TD23_MYCSR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trigger factor HAMAP-Rule MF_00303
Short name=TF HAMAP-Rule MF_00303
EC=5.2.1.8 HAMAP-Rule MF_00303
Alternative name(s):
PPIase HAMAP-Rule MF_00303
Gene names
Name:tig HAMAP-Rule MF_00303
Ordered Locus Names:Mspyr1_20210 EMBL ADT98675.1
OrganismMycobacterium sp. (strain Spyr1) [Complete proteome] [HAMAP] EMBL ADT98675.1
Taxonomic identifier278137 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation By similarity. RuleBase RU003914

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity. HAMAP-Rule MF_00303

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_00303

Subcellular location

Cytoplasm. Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity. HAMAP-Rule MF_00303

Domain

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity. HAMAP-Rule MF_00303

Sequence similarities

Belongs to the FKBP-type PPIase family. Tig subfamily. HAMAP-Rule MF_00303 RuleBase RU003914

Contains 1 PPIase FKBP-type domain. HAMAP-Rule MF_00303

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain162 – 24786PPIase FKBP-type By similarity HAMAP-Rule MF_00303

Sequences

Sequence LengthMass (Da)Tools
E6TD23 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: AA4AA3D4EABBE0EF

FASTA47952,361
        10         20         30         40         50         60 
MKSTVEKLSP TRVRINVEVP FAELEPDIDK AFKQLAQQIR LPGFRPGKAP RKLLEARVGR 

        70         80         90        100        110        120 
GAVLEQVVND ALPTRYSQAV TSESLQPIGQ PEIEVTKLED NEELVFTAEV DVRPEIDLPD 

       130        140        150        160        170        180 
LSTLTITVDP VSVTDEDIEA EIEALQKRFG TLTGVERPAE NGDFVSIDLS ATVDGKDVPE 

       190        200        210        220        230        240 
AKTEGLSHEL GSGQLIEGLD EAIIGLSEDE SKTFTTTLVA GEHAGREAEV TVTVKSIKVR 

       250        260        270        280        290        300 
ELPELDDEFA QLASEFDTMD ELRADLREKV TRVKTVQQAE AIRDKAIEVL LEQTEVPLPE 

       310        320        330        340        350        360 
AVVQAQVDDT LHNAIHGLDH DEDRFADSLK EQGSSREEFD ADNRANAEKA IKTQLLMDAI 

       370        380        390        400        410        420 
ADKLEIQVGQ NDLSERLVLM SRQYGLEPQQ LLQMLQQNNQ LPAMFADVRR GLTVAAVVYA 

       430        440        450        460        470 
ATVTDTDGTE IDTTEFFGPS GDQAAAQQGA GEDDSEAAVE VSEDTADDAS EDDTADDTK

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. Spyr1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L., Koukkou A.I., Drainas C., Kyrpides N., Woyke T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Spyr1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002385 Genomic DNA. Translation: ADT98675.1.
RefSeqYP_004076510.1. NC_014814.1.

3D structure databases

ProteinModelPortalE6TD23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADT98675; ADT98675; Mspyr1_20210.
GeneID10046413.
KEGGmsp:Mspyr1_20210.
PATRIC45285169. VBIMycSp109077_2254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000218240.
KOK03545.
OMAFPADYHG.

Enzyme and pathway databases

BioCycMSP278137:GHD6-2006-MONOMER.

Family and domain databases

Gene3D1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPMF_00303. Trigger_factor_Tig.
InterProIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFPIRSF003095. Trigger_factor. 1 hit.
SUPFAMSSF109998. Trigger_fac_C_bac. 1 hit.
SSF102735. Trigger_fac_ribosome-bd_bac. 1 hit.
TIGRFAMsTIGR00115. tig. 1 hit.
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6TD23_MYCSR
AccessionPrimary (citable) accession number: E6TD23
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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