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Protein

Trigger factor

Gene

tig

Organism
Mycobacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation
Biological processCell cycle, Cell divisionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotation
Ordered Locus Names:Mspyr1_20210Imported
OrganismiMycobacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)Imported
Taxonomic identifieri278137 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000008916 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6TD23
SMRiE6TD23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 215PPIase FKBP-typeInterPro annotationAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 279Sequence analysisAdd BLAST21

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000218240
KOiK03545
OMAiMAMIEDR
OrthoDBiPOG091H01T7

Family and domain databases

Gene3Di1.10.3120.10, 2 hits
3.30.70.1050, 1 hit
HAMAPiMF_00303 Trigger_factor_Tig, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR005215 Trig_fac
IPR008880 Trigger_fac_C
IPR037041 Trigger_fac_C_sf
IPR008881 Trigger_fac_ribosome-bd_bac
IPR036611 Trigger_fac_ribosome-bd_sf
IPR027304 Trigger_fact/SurA_dom_sf
PANTHERiPTHR30560 PTHR30560, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF05698 Trigger_C, 1 hit
PF05697 Trigger_N, 1 hit
PIRSFiPIRSF003095 Trigger_factor, 1 hit
SUPFAMiSSF102735 SSF102735, 1 hit
SSF109998 SSF109998, 1 hit
TIGRFAMsiTIGR00115 tig, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

E6TD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTVEKLSP TRVRINVEVP FAELEPDIDK AFKQLAQQIR LPGFRPGKAP
60 70 80 90 100
RKLLEARVGR GAVLEQVVND ALPTRYSQAV TSESLQPIGQ PEIEVTKLED
110 120 130 140 150
NEELVFTAEV DVRPEIDLPD LSTLTITVDP VSVTDEDIEA EIEALQKRFG
160 170 180 190 200
TLTGVERPAE NGDFVSIDLS ATVDGKDVPE AKTEGLSHEL GSGQLIEGLD
210 220 230 240 250
EAIIGLSEDE SKTFTTTLVA GEHAGREAEV TVTVKSIKVR ELPELDDEFA
260 270 280 290 300
QLASEFDTMD ELRADLREKV TRVKTVQQAE AIRDKAIEVL LEQTEVPLPE
310 320 330 340 350
AVVQAQVDDT LHNAIHGLDH DEDRFADSLK EQGSSREEFD ADNRANAEKA
360 370 380 390 400
IKTQLLMDAI ADKLEIQVGQ NDLSERLVLM SRQYGLEPQQ LLQMLQQNNQ
410 420 430 440 450
LPAMFADVRR GLTVAAVVYA ATVTDTDGTE IDTTEFFGPS GDQAAAQQGA
460 470
GEDDSEAAVE VSEDTADDAS EDDTADDTK
Length:479
Mass (Da):52,361
Last modified:March 8, 2011 - v1
Checksum:iAA4AA3D4EABBE0EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA Translation: ADT98675.1
RefSeqiWP_011893467.1, NC_014814.1

Genome annotation databases

EnsemblBacteriaiADT98675; ADT98675; Mspyr1_20210
KEGGimsp:Mspyr1_20210

Similar proteinsi

Entry informationi

Entry nameiE6TD23_MYCSR
AccessioniPrimary (citable) accession number: E6TD23
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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