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Protein

Trigger factor

Gene

tig

Organism
Mycobacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation
Biological processCell cycle, Cell divisionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotation
Ordered Locus Names:Mspyr1_20210Imported
OrganismiMycobacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)Imported
Taxonomic identifieri278137 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000008916 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6TD23.
SMRiE6TD23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 215PPIase FKBP-typeInterPro annotationAdd BLAST54

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218240.
KOiK03545.
OMAiMAMIEDR.
OrthoDBiPOG091H01T7.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiView protein in InterPro
IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
PANTHERiPTHR30560. PTHR30560. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.

Sequencei

Sequence statusi: Complete.

E6TD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTVEKLSP TRVRINVEVP FAELEPDIDK AFKQLAQQIR LPGFRPGKAP
60 70 80 90 100
RKLLEARVGR GAVLEQVVND ALPTRYSQAV TSESLQPIGQ PEIEVTKLED
110 120 130 140 150
NEELVFTAEV DVRPEIDLPD LSTLTITVDP VSVTDEDIEA EIEALQKRFG
160 170 180 190 200
TLTGVERPAE NGDFVSIDLS ATVDGKDVPE AKTEGLSHEL GSGQLIEGLD
210 220 230 240 250
EAIIGLSEDE SKTFTTTLVA GEHAGREAEV TVTVKSIKVR ELPELDDEFA
260 270 280 290 300
QLASEFDTMD ELRADLREKV TRVKTVQQAE AIRDKAIEVL LEQTEVPLPE
310 320 330 340 350
AVVQAQVDDT LHNAIHGLDH DEDRFADSLK EQGSSREEFD ADNRANAEKA
360 370 380 390 400
IKTQLLMDAI ADKLEIQVGQ NDLSERLVLM SRQYGLEPQQ LLQMLQQNNQ
410 420 430 440 450
LPAMFADVRR GLTVAAVVYA ATVTDTDGTE IDTTEFFGPS GDQAAAQQGA
460 470
GEDDSEAAVE VSEDTADDAS EDDTADDTK
Length:479
Mass (Da):52,361
Last modified:March 8, 2011 - v1
Checksum:iAA4AA3D4EABBE0EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA. Translation: ADT98675.1.
RefSeqiWP_011893467.1. NC_014814.1.

Genome annotation databases

EnsemblBacteriaiADT98675; ADT98675; Mspyr1_20210.
KEGGimsp:Mspyr1_20210.

Similar proteinsi

Entry informationi

Entry nameiE6TD23_MYCSR
AccessioniPrimary (citable) accession number: E6TD23
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported