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E6TD23

- E6TD23_MYCSR

UniProt

E6TD23 - E6TD23_MYCSR

Protein

Trigger factor

Gene

tig

Organism
Mycobacterium sp. (strain Spyr1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.UniRule annotation
    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    ChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation

    Enzyme and pathway databases

    BioCyciMSP278137:GHD6-2006-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotation
    Ordered Locus Names:Mspyr1_20210Imported
    OrganismiMycobacterium sp. (strain Spyr1)Imported
    Taxonomic identifieri278137 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000008916: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE6TD23.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 24786PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000218240.
    KOiK03545.
    OMAiLVHEELM.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6TD23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSTVEKLSP TRVRINVEVP FAELEPDIDK AFKQLAQQIR LPGFRPGKAP    50
    RKLLEARVGR GAVLEQVVND ALPTRYSQAV TSESLQPIGQ PEIEVTKLED 100
    NEELVFTAEV DVRPEIDLPD LSTLTITVDP VSVTDEDIEA EIEALQKRFG 150
    TLTGVERPAE NGDFVSIDLS ATVDGKDVPE AKTEGLSHEL GSGQLIEGLD 200
    EAIIGLSEDE SKTFTTTLVA GEHAGREAEV TVTVKSIKVR ELPELDDEFA 250
    QLASEFDTMD ELRADLREKV TRVKTVQQAE AIRDKAIEVL LEQTEVPLPE 300
    AVVQAQVDDT LHNAIHGLDH DEDRFADSLK EQGSSREEFD ADNRANAEKA 350
    IKTQLLMDAI ADKLEIQVGQ NDLSERLVLM SRQYGLEPQQ LLQMLQQNNQ 400
    LPAMFADVRR GLTVAAVVYA ATVTDTDGTE IDTTEFFGPS GDQAAAQQGA 450
    GEDDSEAAVE VSEDTADDAS EDDTADDTK 479
    Length:479
    Mass (Da):52,361
    Last modified:March 8, 2011 - v1
    Checksum:iAA4AA3D4EABBE0EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002385 Genomic DNA. Translation: ADT98675.1.
    RefSeqiWP_011893467.1. NC_014814.1.
    YP_004076510.1. NC_014814.1.

    Genome annotation databases

    EnsemblBacteriaiADT98675; ADT98675; Mspyr1_20210.
    GeneIDi10046413.
    KEGGimsp:Mspyr1_20210.
    PATRICi45285169. VBIMycSp109077_2254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002385 Genomic DNA. Translation: ADT98675.1 .
    RefSeqi WP_011893467.1. NC_014814.1.
    YP_004076510.1. NC_014814.1.

    3D structure databases

    ProteinModelPortali E6TD23.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADT98675 ; ADT98675 ; Mspyr1_20210 .
    GeneIDi 10046413.
    KEGGi msp:Mspyr1_20210.
    PATRICi 45285169. VBIMycSp109077_2254.

    Phylogenomic databases

    HOGENOMi HOG000218240.
    KOi K03545.
    OMAi LVHEELM.

    Enzyme and pathway databases

    BioCyci MSP278137:GHD6-2006-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Mycobacterium sp. Spyr1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L., Koukkou A.I., Drainas C., Kyrpides N., Woyke T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Spyr1Imported.

    Entry informationi

    Entry nameiE6TD23_MYCSR
    AccessioniPrimary (citable) accession number: E6TD23
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3