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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium sp. (strain Spyr1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641UniRule annotation
Active sitei596 – 5961UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMSP278137:GHD6-3028-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Mspyr1_30480Imported
OrganismiMycobacterium sp. (strain Spyr1)Imported
Taxonomic identifieri278137 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000008916 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6TBL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSPATPDQ SLEPIGAVQR TQVGREATEP MREDIRLLGT ILGDTVREQN
60 70 80 90 100
GDEVFDLVER ARVEAFRVRR SEIDRADMAK LFDDVDVHRA IPVIRAFTHF
110 120 130 140 150
ALLANVAEDI HRERRRRIHE AAGEPPQDSR LDATYLKLDD AGLDAGAVAD
160 170 180 190 200
ALAGALVSPV ITAHPTETRR RTVFDTQHRI TELMRLRLHG HDTTPDGRDV
210 220 230 240 250
EQELRRHILT LWQTALIRLS RLKIQDEIET GLRYYEAALF EVIPQVNAEV
260 270 280 290 300
RAALQQRFPE AGLLEQPIVR PGSWIGGDRD GNPNVTAEVV RLATGNAAYT
310 320 330 340 350
ALAHYFAELT GLEQELSMSA RLVHITDELA ALADSCHEPA RADEPYRRAL
360 370 380 390 400
RVVHARLTAT AQQILDRQPE HELDLGMEPY AAPGELLDDL DVIDASLRAN
410 420 430 440 450
GSAVLADDRL GRLREAVRVF GFHLSGLDMR QNSDVHEEVV AELLAWAGVH
460 470 480 490 500
SDYTSLSEDD RVEILAAELA TRRPLTSPDA DLSELARKEL DIVTAAARAV
510 520 530 540 550
HVFGPQAVPN YIISMCQSVS DMLEAAILLK EAGLLDASSE HPYAPVGIVP
560 570 580 590 600
LFETIDDLQR GSSILEAALD LPLYRGLVSA RGDSQEVMLG YSDSNKDGGY
610 620 630 640 650
LAANWALYRA ELELVESSRK TGIRLRLFHG RGGTVGRGGG PSYDAILAQP
660 670 680 690 700
PGAVQGSLRI TEQGEVIAAK YAEPRIAHRN LETLLAATLE ATLLDMEGLG
710 720 730 740 750
DLAGSAYEVL DDLAARAQRA YAELVHDTPG FVDYFKASTP VSEIGALNIG
760 770 780 790 800
SRPTSRKPTT SISDLRAIPW VLAWSQSRVM LPGWYGTGTA FEDYVGDGDD
810 820 830 840 850
AEARLQVLQD LYRRWPFFAT VLSNMAQVLA KSDLGLAAHY SELVEDEELR
860 870 880 890 900
RRVFDKIVDE HARTIRMHRL ITGHEDLLAD NPSLARSVFN RFPYLEPLNH
910 920 930
LQVELLRRYR SGDEDELVQR GILLTMSGLA TALRNSG
Length:937
Mass (Da):103,500
Last modified:March 8, 2011 - v1
Checksum:iABCF843ED798BC97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA. Translation: ADT99665.1.
RefSeqiWP_013471841.1. NC_014814.1.
YP_004077500.1. NC_014814.1.

Genome annotation databases

EnsemblBacteriaiADT99665; ADT99665; Mspyr1_30480.
KEGGimsp:Mspyr1_30480.
PATRICi45287262. VBIMycSp109077_3276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002385 Genomic DNA. Translation: ADT99665.1.
RefSeqiWP_013471841.1. NC_014814.1.
YP_004077500.1. NC_014814.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT99665; ADT99665; Mspyr1_30480.
KEGGimsp:Mspyr1_30480.
PATRICi45287262. VBIMycSp109077_3276.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.

Enzyme and pathway databases

BioCyciMSP278137:GHD6-3028-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Mycobacterium sp. Spyr1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L., Koukkou A.I., Drainas C., Kyrpides N., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Spyr1Imported.

Entry informationi

Entry nameiE6TBL7_MYCSR
AccessioniPrimary (citable) accession number: E6TBL7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.