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E6T8I7 (E6T8I7_SHEB6) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Sbal678_2092 EMBL ADT94249.1
OrganismShewanella baltica (strain OS678) [Complete proteome] [HAMAP] EMBL ADT94249.1
Taxonomic identifier693973 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain124 – 330207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding154 – 20956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2841Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2971Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2971Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2991Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E6T8I7 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 9A2AE59D58D671F7

FASTA33737,531
        10         20         30         40         50         60 
MSKINLLLLC GGGSAEHDIS LMSANYFETS LAKSEQFSVL RVELDKFGQY RTAAGDDCEL 

        70         80         90        100        110        120 
TNSREIRFRD ESKTPWPVDY VIPCIHGYPG ETGDIQSYFN LIQLPYFGCE SEASSNCFNK 

       130        140        150        160        170        180 
ITAKMWFSAL GIPNTPYIFL NQFDDAAIEQ TQAALAQWGS IFVKAASQGS SVGCYKVDDS 

       190        200        210        220        230        240 
DKVAGVLKDA FGYAPYVIVE KTIKARELEV AVYEYNGEVV ATVPGEIICD TNTFYTFDEK 

       250        260        270        280        290        300 
YAKNSKARTD VVAQHVSAEI SEQIRAYAIK AFKGMKLRHL SRIDFFLTAD NEILLNEINT 

       310        320        330 
FPGSTPISMF PKMLQNHGHD FTEYLSLVIN GQLTAKS 

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS678."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Konstantinidis K. expand/collapse author list , Deng J.I., Hofle M., Brettar I., Tiedje J., Auchtung J., Woyke T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS678 EMBL ADT94249.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002383 Genomic DNA. Translation: ADT94249.1.
RefSeqYP_005273301.1. NC_016901.1.

3D structure databases

ProteinModelPortalE6T8I7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADT94249; ADT94249; Sbal678_2092.
GeneID11772243.
KEGGsbt:Sbal678_2092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycSBAL693973:GJDB-2141-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6T8I7_SHEB6
AccessionPrimary (citable) accession number: E6T8I7
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)