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E6SLB7

- E6SLB7_THEM7

UniProt

E6SLB7 - E6SLB7_THEM7

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMAR644966:GHKT-1272-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Tmar_1235Imported
OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
Taxonomic identifieri644966 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
ProteomesiUP000008915: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6SLB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGYLEVITG GMFSGKTEEL LRRVQRARIA RRQVLLCKPD LDHRYRRDAV
60 70 80 90 100
ASHDGRDLQA AVVPAGRPEE LLALARAARA DVVGIDEAQF FAPGIVPTVL
110 120 130 140 150
ELVAEGRRVI VSGLDMDFAR RPFGPMPELM AVADEVVKLK AICVVCGEPA
160 170 180 190 200
TFTQRLIGGR PAAPDDPVIL IGGQESYEPR CRRHHQLAPG ENPARAQAAP
210 220 230 240 250
AAPLAGPGAA RAAAGTAPAG AGASLAGSAW PAGGPAADPA GPSSPRTLGT
260
PAGEGGSAPA GEEASP
Length:266
Mass (Da):27,344
Last modified:March 8, 2011 - v1
Checksum:i41D81EF5FECC10B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU51348.1.
RefSeqiYP_004102075.1. NC_014831.1.

Genome annotation databases

EnsemblBacteriaiADU51348; ADU51348; Tmar_1235.
GeneIDi10081616.
KEGGitmr:Tmar_1235.
PATRICi45379717. VBITheMar50867_1267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU51348.1 .
RefSeqi YP_004102075.1. NC_014831.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU51348 ; ADU51348 ; Tmar_1235 .
GeneIDi 10081616.
KEGGi tmr:Tmar_1235.
PATRICi 45379717. VBITheMar50867_1267.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.

Enzyme and pathway databases

BioCyci TMAR644966:GHKT-1272-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75aImported.

Entry informationi

Entry nameiE6SLB7_THEM7
AccessioniPrimary (citable) accession number: E6SLB7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3