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E6SLB7

- E6SLB7_THEM7

UniProt

E6SLB7 - E6SLB7_THEM7

Protein

Thymidine kinase

Gene

tdk

Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi181 – 1811ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178ATPUniRule annotation
    Nucleotide bindingi86 – 894ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTMAR644966:GHKT-1272-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Tmar_1235Imported
    OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
    Taxonomic identifieri644966 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
    ProteomesiUP000008915: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDHISEST.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6SLB7-1 [UniParc]FASTAAdd to Basket

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    MAGYLEVITG GMFSGKTEEL LRRVQRARIA RRQVLLCKPD LDHRYRRDAV    50
    ASHDGRDLQA AVVPAGRPEE LLALARAARA DVVGIDEAQF FAPGIVPTVL 100
    ELVAEGRRVI VSGLDMDFAR RPFGPMPELM AVADEVVKLK AICVVCGEPA 150
    TFTQRLIGGR PAAPDDPVIL IGGQESYEPR CRRHHQLAPG ENPARAQAAP 200
    AAPLAGPGAA RAAAGTAPAG AGASLAGSAW PAGGPAADPA GPSSPRTLGT 250
    PAGEGGSAPA GEEASP 266
    Length:266
    Mass (Da):27,344
    Last modified:March 8, 2011 - v1
    Checksum:i41D81EF5FECC10B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002344 Genomic DNA. Translation: ADU51348.1.
    RefSeqiWP_013495653.1. NC_014831.1.
    YP_004102075.1. NC_014831.1.

    Genome annotation databases

    EnsemblBacteriaiADU51348; ADU51348; Tmar_1235.
    GeneIDi10081616.
    KEGGitmr:Tmar_1235.
    PATRICi45379717. VBITheMar50867_1267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002344 Genomic DNA. Translation: ADU51348.1 .
    RefSeqi WP_013495653.1. NC_014831.1.
    YP_004102075.1. NC_014831.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU51348 ; ADU51348 ; Tmar_1235 .
    GeneIDi 10081616.
    KEGGi tmr:Tmar_1235.
    PATRICi 45379717. VBITheMar50867_1267.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DHISEST.

    Enzyme and pathway databases

    BioCyci TMAR644966:GHKT-1272-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75aImported.

    Entry informationi

    Entry nameiE6SLB7_THEM7
    AccessioniPrimary (citable) accession number: E6SLB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3