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E6SH16

- E6SH16_THEM7

UniProt

E6SH16 - E6SH16_THEM7

Protein

Alanine racemase

Gene

Tmar_0526

Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei358 – 3581Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTMAR644966:GHKT-556-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Tmar_0526Imported
    OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
    Taxonomic identifieri644966 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
    ProteomesiUP000008915: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE6SH16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SUPFAMiSSF50621. SSF50621. 2 hits.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6SH16-1 [UniParc]FASTAAdd to Basket

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    MTWPAELAAA LARARIEVDL DVLAANLAAV RRFVRPGTRI LAVVKGDGYG    50
    LGAEMAARTL VAAGADGLGT DTLEAALRLR RAGITAPILV FQPVDPALAH 100
    HWVREGLTAT VHDETTLRRL AQAAESARAG QAARTGSPPG PCAVHLEVDM 150
    GFGRGGFHPD RVAAALAEAQ SLPGIRVEGL YAHFPTAARP GLALRLLDRF 200
    LRLVQRLEQQ GLRPPLVHCA ESHLLVLASH AQLDMVRVGN LLYGYAPRAA 250
    RRAGLAVRPP SRLVVRVGAV RRAASLDPGY RGGWARPGAP VAVLPVGLAD 300
    GLRPVREARF WSDRLVILAR RLLGALGASR VLGAAGLPPG PRLRVGGREV 350
    PLRGEFMMNH CLLDATGLDL EPGQEVELVV GRLTAAAHLP VVYLRGGRPV 400
    AVAWPQRQVV ELVAAPLAFP AGPASGTDGT APDSLAHAGL PAGHPAEVPL 450
    PAAEVPGGAG GDAGAGPVPA AVPGPVACAV QGPVAGPVPA PVRAPAGPVA 500
    ARRGPVRPDE ETVE 514
    Length:514
    Mass (Da):53,114
    Last modified:March 8, 2011 - v1
    Checksum:i1FCCC8D127210BA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002344 Genomic DNA. Translation: ADU50647.1.
    RefSeqiYP_004101374.1. NC_014831.1.

    Genome annotation databases

    EnsemblBacteriaiADU50647; ADU50647; Tmar_0526.
    GeneIDi10080900.
    KEGGitmr:Tmar_0526.
    PATRICi45378226. VBITheMar50867_0529.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002344 Genomic DNA. Translation: ADU50647.1 .
    RefSeqi YP_004101374.1. NC_014831.1.

    3D structure databases

    ProteinModelPortali E6SH16.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU50647 ; ADU50647 ; Tmar_0526 .
    GeneIDi 10080900.
    KEGGi tmr:Tmar_0526.
    PATRICi 45378226. VBITheMar50867_0529.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TMAR644966:GHKT-556-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SUPFAMi SSF50621. SSF50621. 2 hits.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75aImported.

    Entry informationi

    Entry nameiE6SH16_THEM7
    AccessioniPrimary (citable) accession number: E6SH16
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3