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E6SH16

- E6SH16_THEM7

UniProt

E6SH16 - E6SH16_THEM7

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Protein

Alanine racemase

Gene
Tmar_0526
Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Binding sitei358 – 3581Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTMAR644966:GHKT-556-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Tmar_0526Imported
OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
Taxonomic identifieri644966 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
ProteomesiUP000008915: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6SH16.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6SH16-1 [UniParc]FASTAAdd to Basket

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MTWPAELAAA LARARIEVDL DVLAANLAAV RRFVRPGTRI LAVVKGDGYG    50
LGAEMAARTL VAAGADGLGT DTLEAALRLR RAGITAPILV FQPVDPALAH 100
HWVREGLTAT VHDETTLRRL AQAAESARAG QAARTGSPPG PCAVHLEVDM 150
GFGRGGFHPD RVAAALAEAQ SLPGIRVEGL YAHFPTAARP GLALRLLDRF 200
LRLVQRLEQQ GLRPPLVHCA ESHLLVLASH AQLDMVRVGN LLYGYAPRAA 250
RRAGLAVRPP SRLVVRVGAV RRAASLDPGY RGGWARPGAP VAVLPVGLAD 300
GLRPVREARF WSDRLVILAR RLLGALGASR VLGAAGLPPG PRLRVGGREV 350
PLRGEFMMNH CLLDATGLDL EPGQEVELVV GRLTAAAHLP VVYLRGGRPV 400
AVAWPQRQVV ELVAAPLAFP AGPASGTDGT APDSLAHAGL PAGHPAEVPL 450
PAAEVPGGAG GDAGAGPVPA AVPGPVACAV QGPVAGPVPA PVRAPAGPVA 500
ARRGPVRPDE ETVE 514
Length:514
Mass (Da):53,114
Last modified:March 8, 2011 - v1
Checksum:i1FCCC8D127210BA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1.
RefSeqiYP_004101374.1. NC_014831.1.

Genome annotation databases

EnsemblBacteriaiADU50647; ADU50647; Tmar_0526.
GeneIDi10080900.
KEGGitmr:Tmar_0526.
PATRICi45378226. VBITheMar50867_0529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1 .
RefSeqi YP_004101374.1. NC_014831.1.

3D structure databases

ProteinModelPortali E6SH16.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU50647 ; ADU50647 ; Tmar_0526 .
GeneIDi 10080900.
KEGGi tmr:Tmar_0526.
PATRICi 45378226. VBITheMar50867_0529.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TMAR644966:GHKT-556-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SUPFAMi SSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a.

Entry informationi

Entry nameiE6SH16_THEM7
AccessioniPrimary (citable) accession number: E6SH16
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi