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E6SH16

- E6SH16_THEM7

UniProt

E6SH16 - E6SH16_THEM7

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Protein

Alanine racemase

Gene

Tmar_0526

Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei358 – 3581Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMAR644966:GHKT-556-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Tmar_0526Imported
OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
Taxonomic identifieri644966 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
ProteomesiUP000008915: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6SH16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6SH16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTWPAELAAA LARARIEVDL DVLAANLAAV RRFVRPGTRI LAVVKGDGYG
60 70 80 90 100
LGAEMAARTL VAAGADGLGT DTLEAALRLR RAGITAPILV FQPVDPALAH
110 120 130 140 150
HWVREGLTAT VHDETTLRRL AQAAESARAG QAARTGSPPG PCAVHLEVDM
160 170 180 190 200
GFGRGGFHPD RVAAALAEAQ SLPGIRVEGL YAHFPTAARP GLALRLLDRF
210 220 230 240 250
LRLVQRLEQQ GLRPPLVHCA ESHLLVLASH AQLDMVRVGN LLYGYAPRAA
260 270 280 290 300
RRAGLAVRPP SRLVVRVGAV RRAASLDPGY RGGWARPGAP VAVLPVGLAD
310 320 330 340 350
GLRPVREARF WSDRLVILAR RLLGALGASR VLGAAGLPPG PRLRVGGREV
360 370 380 390 400
PLRGEFMMNH CLLDATGLDL EPGQEVELVV GRLTAAAHLP VVYLRGGRPV
410 420 430 440 450
AVAWPQRQVV ELVAAPLAFP AGPASGTDGT APDSLAHAGL PAGHPAEVPL
460 470 480 490 500
PAAEVPGGAG GDAGAGPVPA AVPGPVACAV QGPVAGPVPA PVRAPAGPVA
510
ARRGPVRPDE ETVE
Length:514
Mass (Da):53,114
Last modified:March 8, 2011 - v1
Checksum:i1FCCC8D127210BA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1.
RefSeqiWP_013494952.1. NC_014831.1.
YP_004101374.1. NC_014831.1.

Genome annotation databases

EnsemblBacteriaiADU50647; ADU50647; Tmar_0526.
GeneIDi10080900.
KEGGitmr:Tmar_0526.
PATRICi45378226. VBITheMar50867_0529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1 .
RefSeqi WP_013494952.1. NC_014831.1.
YP_004101374.1. NC_014831.1.

3D structure databases

ProteinModelPortali E6SH16.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU50647 ; ADU50647 ; Tmar_0526 .
GeneIDi 10080900.
KEGGi tmr:Tmar_0526.
PATRICi 45378226. VBITheMar50867_0529.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TMAR644966:GHKT-556-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SUPFAMi SSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75aImported.

Entry informationi

Entry nameiE6SH16_THEM7
AccessioniPrimary (citable) accession number: E6SH16
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3