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Protein

Alanine racemase

Gene

Tmar_0526

Organism
Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei358 – 3581Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMAR644966:GHKT-556-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Tmar_0526Imported
OrganismiThermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)Imported
Taxonomic identifieri644966 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisThermaerobacter
ProteomesiUP000008915 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6SH16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6SH16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWPAELAAA LARARIEVDL DVLAANLAAV RRFVRPGTRI LAVVKGDGYG
60 70 80 90 100
LGAEMAARTL VAAGADGLGT DTLEAALRLR RAGITAPILV FQPVDPALAH
110 120 130 140 150
HWVREGLTAT VHDETTLRRL AQAAESARAG QAARTGSPPG PCAVHLEVDM
160 170 180 190 200
GFGRGGFHPD RVAAALAEAQ SLPGIRVEGL YAHFPTAARP GLALRLLDRF
210 220 230 240 250
LRLVQRLEQQ GLRPPLVHCA ESHLLVLASH AQLDMVRVGN LLYGYAPRAA
260 270 280 290 300
RRAGLAVRPP SRLVVRVGAV RRAASLDPGY RGGWARPGAP VAVLPVGLAD
310 320 330 340 350
GLRPVREARF WSDRLVILAR RLLGALGASR VLGAAGLPPG PRLRVGGREV
360 370 380 390 400
PLRGEFMMNH CLLDATGLDL EPGQEVELVV GRLTAAAHLP VVYLRGGRPV
410 420 430 440 450
AVAWPQRQVV ELVAAPLAFP AGPASGTDGT APDSLAHAGL PAGHPAEVPL
460 470 480 490 500
PAAEVPGGAG GDAGAGPVPA AVPGPVACAV QGPVAGPVPA PVRAPAGPVA
510
ARRGPVRPDE ETVE
Length:514
Mass (Da):53,114
Last modified:March 8, 2011 - v1
Checksum:i1FCCC8D127210BA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1.
RefSeqiWP_013494952.1. NC_014831.1.
YP_004101374.1. NC_014831.1.

Genome annotation databases

EnsemblBacteriaiADU50647; ADU50647; Tmar_0526.
KEGGitmr:Tmar_0526.
PATRICi45378226. VBITheMar50867_0529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002344 Genomic DNA. Translation: ADU50647.1.
RefSeqiWP_013494952.1. NC_014831.1.
YP_004101374.1. NC_014831.1.

3D structure databases

ProteinModelPortaliE6SH16.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU50647; ADU50647; Tmar_0526.
KEGGitmr:Tmar_0526.
PATRICi45378226. VBITheMar50867_0529.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTMAR644966:GHKT-556-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 2 hits.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700841 / DSM 12885 / JCM 10246 / 7p75aImported.

Entry informationi

Entry nameiE6SH16_THEM7
AccessioniPrimary (citable) accession number: E6SH16
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 29, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.