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E6SF43 (E6SF43_INTC7) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Intca_2323
OrganismIntrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP) [Complete proteome] [HAMAP] EMBL ADU48832.1
Taxonomic identifier710696 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Intrasporangiaceae › Intrasporangium ›

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS000291

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS000291

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS000291.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS000291

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain174 – 384211ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding206 – 26156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3381Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3511Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3511Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3531Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E6SF43 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 7EEA04C0256F9F28

FASTA39442,242
        10         20         30         40         50         60 
MTSDQQPVQP RDPDSAHPAA ASDGHQNHRP RVAIIFGGRS SEHAVSCATA AGVMRAIDRD 

        70         80         90        100        110        120 
KYDIVPIGVS RDGQWVLVAD DPARFELTAG RTPEVLPDRA HVVLPLSTRD TALTVLEAGQ 

       130        140        150        160        170        180 
PPRELGDVDV VLPLLHGPFG EDGTLQGFLE LSDIRYVGSG VFASAAGMDK HYMKVVFAGH 

       190        200        210        220        230        240 
GLPVGPYAVI TDRAWRADRA AALDSCAALD FPVFVKPARA GSSMGISKVD DPGLLEAAIE 

       250        260        270        280        290        300 
RAREHDPKVI VEAGITGREI ECAVLEGHGT QGPRTSQVGE VAVHDNHAFY DFEAKYLAEA 

       310        320        330        340        350        360 
DVDLSCPADV PAHVSDEVRR LSAAAFEALG CEGLARVDCF YAEDGRVLIN EINTMPGFTP 

       370        380        390 
HSMYPRMWAA SGLPYTALID ELISLALVRR TGLR

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002343 Genomic DNA. Translation: ADU48832.1.
RefSeqYP_004099559.1. NC_014830.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU48832; ADU48832; Intca_2323.
GeneID10085147.
KEGGica:Intca_2323.
PATRIC45246230. VBIIntCal153415_2373.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycICAL710696:GH9U-2364-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6SF43_INTC7
AccessionPrimary (citable) accession number: E6SF43
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 29, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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