ID   E6S864_INTC7            Unreviewed;       825 AA.
AC   E6S864;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Intca_0420 {ECO:0000313|EMBL:ADU46968.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC
OS   12989 / 7 KIP).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46968.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46968.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S., Cheng J.F.,
RA   Detter C., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Pati A., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Pukall R., Sikorski J.,
RA   Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7 KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP002343; ADU46968.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6S864; -.
DR   STRING; 710696.Intca_0420; -.
DR   KEGG; ica:Intca_0420; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_413802_0_0_11; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..825
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038782794"
FT   DOMAIN          672..824
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
SQ   SEQUENCE   825 AA;  87126 MW;  F60C38732FF383E5 CRC64;
     MHTRRAALAG LALTVSIPLT VPLSVPVAMA GAAAATAADQ TGITRTDLDH TGDGYPVYRI
     PALTKTTDGT LVAAYDGRPS YGDVPNNIAL VVRRSTDDGS TWEDRQVVRY EAGKPGFGDP
     SLVTDRVTGR IWLFHAASVN QGYFGSTTGT DDADPNVLHA DVSWSDDDGL TWQHRRLTSE
     VKDPQWGGLF AASGEGIQIR RGPHQGRLVQ QYAIRYQGGN WAASLISDDH GETWRFGDLL
     GPGMDENKVV ELSDGRLMLN SRAPGGYRKV AYSSDGGETW SGLHADDELV DPQNNGSIIR
     YDADAAPSSP DAAKLLFSNT ATQSGRRNLT IRQSCDNGET WPIRKVVEPG AAEYSTLTPL
     GDQQFGLLYE RGGYQHISFA RFGGDWLDGV CAPLTSRTVT AGSPGGTAEV EVKVTSQETG
     AIDGGRVALD LPSGFTAPEV PVAKLSRGAT ATVRIPVRMP EGAVTNAYPY TARFLSDKGS
     SQSGGSIVVK GGNVVLSDST ERSYDGATIT DLTDRVDAVK DLTGGAVTVR FSTTARPAVG
     TLLSLADPIS AVRDVIVSLN GGRPYVEVRT ATSTYPIRLQ SSVDVADGKV HELIAASNAG
     VTSLILDDAV IAQVDGQGFF ADVTALTRPH TLNPSGKPNL TLGMNRGHFS VNGGPAAPNS
     RWGFVGTIHS VEVSDDLRTG EELVPAAGLS IASVSSEETA GEDGRAANAV DGNPATIWHS
     KWTGTAAEYP HQITVDLGQA QPLTALRYLR RAVGTNGDIA DHVVSVSDDN VSWTQVATGT
     FAATKGEEEV RFAPQTARYV RLEALSAVNG LQFAAAAELR PVRTS
//