ID   E6S796_INTC7            Unreviewed;       437 AA.
AC   E6S796;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Metal dependent phosphohydrolase {ECO:0000313|EMBL:ADU49030.1};
GN   OrderedLocusNames=Intca_2524 {ECO:0000313|EMBL:ADU49030.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC
OS   12989 / 7 KIP).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU49030.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU49030.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S., Cheng J.F.,
RA   Detter C., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Pati A., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Pukall R., Sikorski J.,
RA   Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7 KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
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DR   EMBL; CP002343; ADU49030.1; -; Genomic_DNA.
DR   RefSeq; WP_013493344.1; NC_014830.1.
DR   AlphaFoldDB; E6S796; -.
DR   STRING; 710696.Intca_2524; -.
DR   KEGG; ica:Intca_2524; -.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_637654_0_0_11; -.
DR   OrthoDB; 40937at2; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   PANTHER; PTHR45228:SF4; LIPOPROTEIN-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        42..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          248..435
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
SQ   SEQUENCE   437 AA;  46371 MW;  E217CB9914DB71AC CRC64;
     MNATLAERVK PLSAAAAAIA TCVILVVLSA DSPAWDEADS AVLVATFTAA ILLGEWFQVA
     GPRFRESAPL ATAAALGFVF TAQLPDGRGV SYGSVFLLAV TASAITVVAL VRHLTGRQVS
     PVETTGRFVS VAVAALLYRV VHLGQVRGRP VGDDGLDPWQ RAVLMLAIAV VALLADAFVT
     TTARALLRAA WWQTFKDEVR STFPLSTALA VTGVLIALAV PPLGAPAVPL FLSPLVLTLF
     AFRRYVSIRA TYLQSIRTLS RLTDAAGYTP AGHSERVAAT ALAVGRGLGL PDRELANLEY
     AALLHDIGQV ALVDPIPGGA TVLAAPADQR RIGADTLAIV RETGVLDDAA TILEHQATPF
     RQAREFGEEI PLTSRILKVV NAYEDLTGGS RSPRARETAV ERIYLGLGYE YDPHVVDALL
     RHLDASGLLV TPQELRR
//