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E6S223 (E6S223_HELPF) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
UDP-N-acetylmuramate--L-alanine ligase EMBL ADU41075.1
EC=6.3.2.8 EMBL ADU41075.1
Gene names
Name:murC EMBL ADU41075.1
Ordered Locus Names:HMPREF4655_20976
OrganismHelicobacter pylori (strain 35A) [Complete proteome] [HAMAP]
Taxonomic identifier585535 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS005758

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. SAAS SAAS005758

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005758

Subcellular location

Cytoplasm By similarity SAAS SAAS005758.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
E6S223 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: C457783762C08389

FASTA44950,876
        10         20         30         40         50         60 
MLETPKVLLK NLQDCKIHFI GIGGIGISGL AKYLKAQGAT ISGSDIAISP SVKYLKALGV 

        70         80         90        100        110        120 
EINIPHDPKA IKNQDAIIHS AIIKENNTEI QRAKELEIPI LSRKDALYSI LKDKRVFSVC 

       130        140        150        160        170        180 
GAHGKSSITA MLSAICPFFG AIIGAHSKEF DSNVRESAND SLVFEADESD SSFLFSNPYA 

       190        200        210        220        230        240 
AIVPNTEPEH LEHYDHDLER FFFAYEYFLD HAQKRVIYKE DPFLKHYSKD AIVLEKKDIR 

       250        260        270        280        290        300 
NIQYILKDGE PYTSFELKDL GVFLVWGLGE HNATNASLAI LSALDELDLE EIRNNLLHFK 

       310        320        330        340        350        360 
GIKKRFDILQ KNALILIDDY AHHPTEISAT LKSARIYANL LNTQEKIVVI WQAHKYSRLM 

       370        380        390        400        410        420 
DNLEEFKKCF LEHCDRLIIL PVYSANEVKR DIDLKAHFKH YNPTFIDRVR KKGALLELLV 

       430        440 
NDNVVETIQK GFVIGFGAGD ITYQLRGEM

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References

« Hide 'large scale' references
[1]"Complete genome sequence of Helicobacter pylori 35A."
Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. expand/collapse author list , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35A.
[2]Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. expand/collapse author list , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 35A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002096 Genomic DNA. Translation: ADU41075.1.
RefSeqYP_005770067.1. NC_017360.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU41075; ADU41075; HMPREF4655_20976.
GeneID12348018.
KEGGhpo:HMPREF4655_20976.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01924.
OMAYQPHRYS.

Enzyme and pathway databases

BioCycHPYL585535:GLE3-952-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. murC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE6S223_HELPF
AccessionPrimary (citable) accession number: E6S223
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 29, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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