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E6S1S2 (E6S1S2_HELPF) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HMPREF4655_20862 EMBL ADU40974.1
OrganismHelicobacter pylori (strain 35A) [Complete proteome] [HAMAP] EMBL ADU40974.1
Taxonomic identifier585535 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain143 – 341199ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding170 – 22556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2971Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3091Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3091Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3111Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E6S1S2 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 7B479B4AABD413FC

FASTA35640,668
        10         20         30         40         50         60 
MQSFLGSLIV EFCVLFGGAS FEHEISIVSA IALKEALKDR IKYFIFLDEN HHFYLIEESN 

        70         80         90        100        110        120 
MHSKYFAQIK EKKLPPLILT RNGLLKNSFL GTKIIELPLV INLVHGGDGE DGKLASLLEF 

       130        140        150        160        170        180 
YRIAFIGPRI EASVLSYNKY LTKLYAKDLG VKTLDYVLLN EKNRANALNL IGFNFPFIVK 

       190        200        210        220        230        240 
PSNAGSSLGV SVVKEEKELI YALDGAFEYS KEVLIEPFIQ GVKEYNLAGC KIKKDFCFSY 

       250        260        270        280        290        300 
IEEPNKQEFL DFKQKYLDFS RNKAPKANLS NALEEQLKEN FKKLYNDLFD GALVRCDFFV 

       310        320        330        340        350 
IENEVYLNEI NPIPGSLANY LFDDFKTTLE NLVQSLPKTP KIPIKNSYLL QIQKNK 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Helicobacter pylori 35A."
Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. expand/collapse author list , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35A.
[2]Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. expand/collapse author list , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 35A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002096 Genomic DNA. Translation: ADU40974.1.
RefSeqYP_005769966.1. NC_017360.1.

3D structure databases

ProteinModelPortalE6S1S2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU40974; ADU40974; HMPREF4655_20862.
GeneID12349472.
KEGGhpo:HMPREF4655_20862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKYMDFSR.

Enzyme and pathway databases

BioCycHPYL585535:GLE3-846-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6S1S2_HELPF
AccessionPrimary (citable) accession number: E6S1S2
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)