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E6RXV9

- E6RXV9_CAMJC

UniProt

E6RXV9 - E6RXV9_CAMJC

Protein

Alanine racemase

Gene

ICDCCJ07001_860

Organism
Campylobacter jejuni subsp. jejuni serotype HS:41 (strain ICDCCJ07001)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Active sitei237 – 2371Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei283 – 2831Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCJEJ757425:GJ7N-861-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:ICDCCJ07001_860Imported
    OrganismiCampylobacter jejuni subsp. jejuni serotype HS:41 (strain ICDCCJ07001)Imported
    Taxonomic identifieri757425 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000008121: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE6RXV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031446.
    KOiK01775.
    OMAiNIRADEM.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E6RXV9-1 [UniParc]FASTAAdd to Basket

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    MSLIKIDQKA YEYNLRHIAK KIGSFQRLIC VFKDNAYGHG AKLLAPLAKN    50
    LGVSFVAVKS EEEAQEIEEF FENILILSHR PHGNENSRFI YALNDISQVK 100
    KYKQDIKIHL KIDTGMHRNG ICVENLEHAI DLIQSSDLKL TGMFTHFASA 150
    DEMDGSFFVQ KENFQKAKKI VKKYFSNLLF HSHNSAALFR GKIPEDEYCR 200
    VGLVQFGYGD SNLKKVLSLY AHRLSQRILQ KGQSIGYGGI FTAAKDMEVA 250
    TYDLGYADGL FRYNGKGELV LGNGKVMLGK MSMDSFSCEN SGEEICVFKD 300
    ADIWADFFHT INYEILVKLN PNIQRVLV 328
    Length:328
    Mass (Da):37,219
    Last modified:March 8, 2011 - v1
    Checksum:iD27FFBB75173AAFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002029 Genomic DNA. Translation: ADT66216.1.
    RefSeqiYP_004066405.1. NC_014802.1.

    Genome annotation databases

    EnsemblBacteriaiADT66216; ADT66216; ICDCCJ07001_860.
    GeneIDi10036127.
    KEGGicjn:ICDCCJ_860.
    PATRICi45194183. VBICamJej156877_1020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002029 Genomic DNA. Translation: ADT66216.1 .
    RefSeqi YP_004066405.1. NC_014802.1.

    3D structure databases

    ProteinModelPortali E6RXV9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADT66216 ; ADT66216 ; ICDCCJ07001_860 .
    GeneIDi 10036127.
    KEGGi cjn:ICDCCJ_860.
    PATRICi 45194183. VBICamJej156877_1020.

    Phylogenomic databases

    HOGENOMi HOG000031446.
    KOi K01775.
    OMAi NIRADEM.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CJEJ757425:GJ7N-861-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 isolate."
      Zhang M., He L., Li Q., Sun H., Gu Y., You Y., Meng F., Zhang J.
      PLoS ONE 5:E15060-E15060(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ICDCCJ07001Imported.

    Entry informationi

    Entry nameiE6RXV9_CAMJC
    AccessioniPrimary (citable) accession number: E6RXV9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3