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Protein

Alanine racemase

Gene

ICDCCJ07001_860

Organism
Campylobacter jejuni subsp. jejuni serotype HS:41 (strain ICDCCJ07001)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Active sitei237 – 2371Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei283 – 2831Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCJEJ757425:GJ7N-861-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ICDCCJ07001_860Imported
OrganismiCampylobacter jejuni subsp. jejuni serotype HS:41 (strain ICDCCJ07001)Imported
Taxonomic identifieri757425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000008121: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6RXV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiNTVMVDV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6RXV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLIKIDQKA YEYNLRHIAK KIGSFQRLIC VFKDNAYGHG AKLLAPLAKN
60 70 80 90 100
LGVSFVAVKS EEEAQEIEEF FENILILSHR PHGNENSRFI YALNDISQVK
110 120 130 140 150
KYKQDIKIHL KIDTGMHRNG ICVENLEHAI DLIQSSDLKL TGMFTHFASA
160 170 180 190 200
DEMDGSFFVQ KENFQKAKKI VKKYFSNLLF HSHNSAALFR GKIPEDEYCR
210 220 230 240 250
VGLVQFGYGD SNLKKVLSLY AHRLSQRILQ KGQSIGYGGI FTAAKDMEVA
260 270 280 290 300
TYDLGYADGL FRYNGKGELV LGNGKVMLGK MSMDSFSCEN SGEEICVFKD
310 320
ADIWADFFHT INYEILVKLN PNIQRVLV
Length:328
Mass (Da):37,219
Last modified:March 8, 2011 - v1
Checksum:iD27FFBB75173AAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002029 Genomic DNA. Translation: ADT66216.1.
RefSeqiYP_004066405.1. NC_014802.1.

Genome annotation databases

EnsemblBacteriaiADT66216; ADT66216; ICDCCJ07001_860.
GeneIDi10036127.
KEGGicjn:ICDCCJ_860.
PATRICi45194183. VBICamJej156877_1020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002029 Genomic DNA. Translation: ADT66216.1.
RefSeqiYP_004066405.1. NC_014802.1.

3D structure databases

ProteinModelPortaliE6RXV9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT66216; ADT66216; ICDCCJ07001_860.
GeneIDi10036127.
KEGGicjn:ICDCCJ_860.
PATRICi45194183. VBICamJej156877_1020.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiNTVMVDV.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCJEJ757425:GJ7N-861-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 isolate."
    Zhang M., He L., Li Q., Sun H., Gu Y., You Y., Meng F., Zhang J.
    PLoS ONE 5:E15060-E15060(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ICDCCJ07001Imported.

Entry informationi

Entry nameiE6RXV9_CAMJC
AccessioniPrimary (citable) accession number: E6RXV9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.