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Protein
Submitted name:

Isocitrate dehydrogenase (NADP) Monomeric isocitrate dehydrogenase (NADP)

Gene

icd

Organism
Campylobacter jejuni subsp. jejuni (strain S3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421SubstrateUniRule annotation
Sitei252 – 2521Critical for catalysisUniRule annotation
Metal bindingi345 – 3451Magnesium or manganeseUniRule annotation
Sitei415 – 4151Critical for catalysisUniRule annotation
Binding sitei538 – 5381SubstrateUniRule annotation
Metal bindingi539 – 5391Magnesium or manganeseUniRule annotation
Metal bindingi543 – 5431Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCJEJ718271:GLAE-530-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP) Monomeric isocitrate dehydrogenase (NADP)Imported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:CJS3_0521Imported
OrganismiCampylobacter jejuni subsp. jejuni (strain S3)Imported
Taxonomic identifieri718271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006628: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE6RVR6.
SMRiE6RVR6. Positions 2-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1368Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

E6RVR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITYTLTDE SPALATYSFL PIVKAFLSRA HIGVKTSDIS LSGRILATFS
60 70 80 90 100
EYLKEEQRCE DALELLGELV KRSDANLIKT PNISASIPQL KAAIKELQDK
110 120 130 140 150
GYMLPNYPDE PKNDEELQIK TKYQKVLGSA VNPVLRQGNS DRRSTKAVKD
160 170 180 190 200
YAKNNPYRVV EFNPNSKTRV SYMKEGDFFS NEKAVLIDQD CVANIEFTSV
210 220 230 240 250
DGKKEILKEG LKLEKNEILD ATFMDVQKLQ EFYAKEIKAS KDDDVLFSLH
260 270 280 290 300
LKATMMKVSD PILFGYAVKV FFKELFIEFQ DEFEKLGINP NNGLSELLSK
310 320 330 340 350
IENSSKKDEI LKKYNEILAK SADISMVNSD KGITNLHVPS DVIVDASMPA
360 370 380 390 400
MLKNGARLWD KEGKEKDTNA VIPDQTYATI YEAVIEDLHK NGTLNPSKLG
410 420 430 440 450
SVSNVGLMAK KAQEYGSHDK TFVAKEEGTF KIVSNGKVLL EHKVRKGDIY
460 470 480 490 500
RANQAKFDAV LNWIDLGIER SELSGAEAIF WLDSKRASNK IMITLVQNRL
510 520 530 540 550
KEKGKNVAIL TPKEACLRSL ELIREGKDVI SITGNVLRDY LTDLFPILEL
560 570 580 590 600
GTSAKMLSVV PMLNGGAMFE TGAGGSAPKQ VEQLVEENHL RWDSLGEFLA
610 620 630 640 650
LQASLEFYAN KCGNHKAKVL AECLDEAIGE WLENNKAPSR KVKEDDNRTS
660 670 680 690 700
HFYLAMYFAN HLARQASDME LQSFFKDIAL ELSSNEEKIR AEFNDAQGVK
710 720 730
VDLGGYYKFD DEKANKIMRP SATFNAILEK IGQR
Length:734
Mass (Da):82,358
Last modified:March 8, 2011 - v1
Checksum:i0EF7140D92ACFD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001960 Genomic DNA. Translation: ADT72278.1.
RefSeqiYP_005659114.1. NC_017281.1.

Genome annotation databases

EnsemblBacteriaiADT72278; ADT72278; CJS3_0521.
GeneIDi12246929.
KEGGicjs:CJS3_0521.
PATRICi45417885. VBICamJej157961_0518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001960 Genomic DNA. Translation: ADT72278.1.
RefSeqiYP_005659114.1. NC_017281.1.

3D structure databases

ProteinModelPortaliE6RVR6.
SMRiE6RVR6. Positions 2-731.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT72278; ADT72278; CJS3_0521.
GeneIDi12246929.
KEGGicjs:CJS3_0521.
PATRICi45417885. VBICamJej157961_0518.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciCJEJ718271:GLAE-530-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Campylobacter jejuni strain S3."
    Cooper K.K., Cooper M.A., Zuccolo A., Law B., Joens L.A.
    J. Bacteriol. 193:1491-1492(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S3Imported.

Entry informationi

Entry nameiE6RVR6_CAMJS
AccessioniPrimary (citable) accession number: E6RVR6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.