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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Pseudoalteromonas sp. (strain SM9913)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Metal cation 1UniRule annotation1
Metal bindingi24Metal cation 1UniRule annotation1
Binding sitei24cAMPUniRule annotation1
Metal bindingi62Metal cation 1UniRule annotation1
Metal bindingi62Metal cation 2UniRule annotation1
Binding sitei62cAMPUniRule annotation1
Metal bindingi94Metal cation 2UniRule annotation1
Metal bindingi160Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 2UniRule annotation1
Metal bindingi200Metal cation 1UniRule annotation1
Binding sitei200cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi94 – 95cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:PSM_A2567
OrganismiPseudoalteromonas sp. (strain SM9913)
Taxonomic identifieri234831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133721 – 2613',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST261

Interactioni

Protein-protein interaction databases

STRINGi234831.PSM_A2567

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
HOGENOMiHOG000131966
KOiK03651
OMAiIPVFWIP
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

E6RHP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWFDDTYYF EQAQLRIAHI TDCHLFSDKQ GEYFGVNTAE HFTRALTDIA
60 70 80 90 100
KQQPDALIFG GDLTQDHSFN SYLLFAELIH NSDLDCPVFW VPGNHDEIDQ
110 120 130 140 150
LNLISGGQIQ RAKHIVAQGF ELILINSKGN TPAGWVTPSH LEEIMACLVD
160 170 180 190 200
SDNRHIAFCH HNPLPINGYL DKHMLENGPQ LLNLLVNNGR VDALFHGHVH
210 220 230 240 250
NDYQQQFREL DIYATPASSV QFTKHSATWQ QEDKGAAYRM LHLNAEQQKV
260
HIRTDVVWLN E
Length:261
Mass (Da):29,827
Last modified:March 8, 2011 - v1
Checksum:i7198C0473A20180E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001796 Genomic DNA Translation: ADT69481.1
RefSeqiWP_013465837.1, NC_014803.1

Genome annotation databases

EnsemblBacteriaiADT69481; ADT69481; PSM_A2567
KEGGipsm:PSM_A2567

Similar proteinsi

Entry informationi

Entry nameiCPDA_PSEU9
AccessioniPrimary (citable) accession number: E6RHP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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