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E6RHP9 (CPDA_PSEU9) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:PSM_A2567
OrganismPseudoalteromonas sp. (strain SM9913) [Complete proteome] [HAMAP]
Taxonomic identifier234831 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2612613',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413372

Regions

Nucleotide binding94 – 952cAMP By similarity

Sites

Metal binding221Metal cation 1 By similarity
Metal binding241Metal cation 1 By similarity
Metal binding621Metal cation 1 By similarity
Metal binding621Metal cation 2 By similarity
Metal binding941Metal cation 2 By similarity
Metal binding1601Metal cation 2 By similarity
Metal binding1981Metal cation 2 By similarity
Metal binding2001Metal cation 1 By similarity
Binding site241cAMP By similarity
Binding site621cAMP By similarity
Binding site2001cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
E6RHP9 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 7198C0473A20180E

FASTA26129,827
        10         20         30         40         50         60 
MAWFDDTYYF EQAQLRIAHI TDCHLFSDKQ GEYFGVNTAE HFTRALTDIA KQQPDALIFG 

        70         80         90        100        110        120 
GDLTQDHSFN SYLLFAELIH NSDLDCPVFW VPGNHDEIDQ LNLISGGQIQ RAKHIVAQGF 

       130        140        150        160        170        180 
ELILINSKGN TPAGWVTPSH LEEIMACLVD SDNRHIAFCH HNPLPINGYL DKHMLENGPQ 

       190        200        210        220        230        240 
LLNLLVNNGR VDALFHGHVH NDYQQQFREL DIYATPASSV QFTKHSATWQ QEDKGAAYRM 

       250        260 
LHLNAEQQKV HIRTDVVWLN E 

« Hide

References

[1]"Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913."
Qin Q.L., Li Y., Zhang Y.J., Zhou Z.M., Zhang W.X., Chen X.L., Zhang X.Y., Zhou B.C., Wang L., Zhang Y.Z.
ISME J. 5:274-284(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SM9913.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001796 Genomic DNA. Translation: ADT69481.1.
RefSeqYP_004069632.1. NC_014803.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADT69481; ADT69481; PSM_A2567.
GeneID10039433.
KEGGpsm:PSM_A2567.
PATRIC45332580. VBIPseSp136886_3146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000131966.
KOK03651.
OMAWQIIMLD.

Enzyme and pathway databases

BioCycPSP234831:GH93-2602-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_PSEU9
AccessionPrimary (citable) accession number: E6RHP9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 8, 2011
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families