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E6RHP9

- CPDA_PSEU9

UniProt

E6RHP9 - CPDA_PSEU9

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Pseudoalteromonas sp. (strain SM9913)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221Metal cation 1UniRule annotation
    Metal bindingi24 – 241Metal cation 1UniRule annotation
    Binding sitei24 – 241cAMPUniRule annotation
    Metal bindingi62 – 621Metal cation 1UniRule annotation
    Metal bindingi62 – 621Metal cation 2UniRule annotation
    Binding sitei62 – 621cAMPUniRule annotation
    Metal bindingi94 – 941Metal cation 2UniRule annotation
    Metal bindingi160 – 1601Metal cation 2UniRule annotation
    Metal bindingi198 – 1981Metal cation 2UniRule annotation
    Metal bindingi200 – 2001Metal cation 1UniRule annotation
    Binding sitei200 – 2001cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi94 – 952cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPSP234831:GH93-2602-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:PSM_A2567
    OrganismiPseudoalteromonas sp. (strain SM9913)
    Taxonomic identifieri234831 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000007933: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2612613',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413372Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000131966.
    KOiK03651.
    OMAiWQIIMLD.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E6RHP9-1 [UniParc]FASTAAdd to Basket

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    MAWFDDTYYF EQAQLRIAHI TDCHLFSDKQ GEYFGVNTAE HFTRALTDIA    50
    KQQPDALIFG GDLTQDHSFN SYLLFAELIH NSDLDCPVFW VPGNHDEIDQ 100
    LNLISGGQIQ RAKHIVAQGF ELILINSKGN TPAGWVTPSH LEEIMACLVD 150
    SDNRHIAFCH HNPLPINGYL DKHMLENGPQ LLNLLVNNGR VDALFHGHVH 200
    NDYQQQFREL DIYATPASSV QFTKHSATWQ QEDKGAAYRM LHLNAEQQKV 250
    HIRTDVVWLN E 261
    Length:261
    Mass (Da):29,827
    Last modified:March 8, 2011 - v1
    Checksum:i7198C0473A20180E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001796 Genomic DNA. Translation: ADT69481.1.
    RefSeqiYP_004069632.1. NC_014803.1.

    Genome annotation databases

    EnsemblBacteriaiADT69481; ADT69481; PSM_A2567.
    GeneIDi10039433.
    KEGGipsm:PSM_A2567.
    PATRICi45332580. VBIPseSp136886_3146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001796 Genomic DNA. Translation: ADT69481.1 .
    RefSeqi YP_004069632.1. NC_014803.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADT69481 ; ADT69481 ; PSM_A2567 .
    GeneIDi 10039433.
    KEGGi psm:PSM_A2567.
    PATRICi 45332580. VBIPseSp136886_3146.

    Phylogenomic databases

    HOGENOMi HOG000131966.
    KOi K03651.
    OMAi WQIIMLD.

    Enzyme and pathway databases

    BioCyci PSP234831:GH93-2602-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913."
      Qin Q.L., Li Y., Zhang Y.J., Zhou Z.M., Zhang W.X., Chen X.L., Zhang X.Y., Zhou B.C., Wang L., Zhang Y.Z.
      ISME J. 5:274-284(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SM9913.

    Entry informationi

    Entry nameiCPDA_PSEU9
    AccessioniPrimary (citable) accession number: E6RHP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3