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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Pseudoalteromonas sp. (strain SM9913)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Metal cation 1UniRule annotation1
Metal bindingi24Metal cation 1UniRule annotation1
Binding sitei24cAMPUniRule annotation1
Metal bindingi62Metal cation 1UniRule annotation1
Metal bindingi62Metal cation 2UniRule annotation1
Binding sitei62cAMPUniRule annotation1
Metal bindingi94Metal cation 2UniRule annotation1
Metal bindingi160Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 2UniRule annotation1
Metal bindingi200Metal cation 1UniRule annotation1
Binding sitei200cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi94 – 95cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:PSM_A2567
OrganismiPseudoalteromonas sp. (strain SM9913)
Taxonomic identifieri234831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000007933 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133721 – 2613',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST261

Interactioni

Protein-protein interaction databases

STRINGi234831.PSM_A2567.

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000131966.
KOiK03651.
OMAiESYHSFV.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

E6RHP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWFDDTYYF EQAQLRIAHI TDCHLFSDKQ GEYFGVNTAE HFTRALTDIA
60 70 80 90 100
KQQPDALIFG GDLTQDHSFN SYLLFAELIH NSDLDCPVFW VPGNHDEIDQ
110 120 130 140 150
LNLISGGQIQ RAKHIVAQGF ELILINSKGN TPAGWVTPSH LEEIMACLVD
160 170 180 190 200
SDNRHIAFCH HNPLPINGYL DKHMLENGPQ LLNLLVNNGR VDALFHGHVH
210 220 230 240 250
NDYQQQFREL DIYATPASSV QFTKHSATWQ QEDKGAAYRM LHLNAEQQKV
260
HIRTDVVWLN E
Length:261
Mass (Da):29,827
Last modified:March 8, 2011 - v1
Checksum:i7198C0473A20180E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001796 Genomic DNA. Translation: ADT69481.1.
RefSeqiWP_013465837.1. NC_014803.1.

Genome annotation databases

EnsemblBacteriaiADT69481; ADT69481; PSM_A2567.
KEGGipsm:PSM_A2567.
PATRICi45332580. VBIPseSp136886_3146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001796 Genomic DNA. Translation: ADT69481.1.
RefSeqiWP_013465837.1. NC_014803.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234831.PSM_A2567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT69481; ADT69481; PSM_A2567.
KEGGipsm:PSM_A2567.
PATRICi45332580. VBIPseSp136886_3146.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000131966.
KOiK03651.
OMAiESYHSFV.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_PSEU9
AccessioniPrimary (citable) accession number: E6RHP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.