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E6RHP9

- CPDA_PSEU9

UniProt

E6RHP9 - CPDA_PSEU9

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Pseudoalteromonas sp. (strain SM9913)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Metal cation 1UniRule annotation
Metal bindingi24 – 241Metal cation 1UniRule annotation
Binding sitei24 – 241cAMPUniRule annotation
Metal bindingi62 – 621Metal cation 1UniRule annotation
Metal bindingi62 – 621Metal cation 2UniRule annotation
Binding sitei62 – 621cAMPUniRule annotation
Metal bindingi94 – 941Metal cation 2UniRule annotation
Metal bindingi160 – 1601Metal cation 2UniRule annotation
Metal bindingi198 – 1981Metal cation 2UniRule annotation
Metal bindingi200 – 2001Metal cation 1UniRule annotation
Binding sitei200 – 2001cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi94 – 952cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP234831:GH93-2602-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:PSM_A2567
OrganismiPseudoalteromonas sp. (strain SM9913)
Taxonomic identifieri234831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000007933: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2612613',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413372Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000131966.
KOiK03651.
OMAiWQIIMLD.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

E6RHP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWFDDTYYF EQAQLRIAHI TDCHLFSDKQ GEYFGVNTAE HFTRALTDIA
60 70 80 90 100
KQQPDALIFG GDLTQDHSFN SYLLFAELIH NSDLDCPVFW VPGNHDEIDQ
110 120 130 140 150
LNLISGGQIQ RAKHIVAQGF ELILINSKGN TPAGWVTPSH LEEIMACLVD
160 170 180 190 200
SDNRHIAFCH HNPLPINGYL DKHMLENGPQ LLNLLVNNGR VDALFHGHVH
210 220 230 240 250
NDYQQQFREL DIYATPASSV QFTKHSATWQ QEDKGAAYRM LHLNAEQQKV
260
HIRTDVVWLN E
Length:261
Mass (Da):29,827
Last modified:March 8, 2011 - v1
Checksum:i7198C0473A20180E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001796 Genomic DNA. Translation: ADT69481.1.
RefSeqiYP_004069632.1. NC_014803.1.

Genome annotation databases

EnsemblBacteriaiADT69481; ADT69481; PSM_A2567.
GeneIDi10039433.
KEGGipsm:PSM_A2567.
PATRICi45332580. VBIPseSp136886_3146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001796 Genomic DNA. Translation: ADT69481.1 .
RefSeqi YP_004069632.1. NC_014803.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADT69481 ; ADT69481 ; PSM_A2567 .
GeneIDi 10039433.
KEGGi psm:PSM_A2567.
PATRICi 45332580. VBIPseSp136886_3146.

Phylogenomic databases

HOGENOMi HOG000131966.
KOi K03651.
OMAi WQIIMLD.

Enzyme and pathway databases

BioCyci PSP234831:GH93-2602-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913."
    Qin Q.L., Li Y., Zhang Y.J., Zhou Z.M., Zhang W.X., Chen X.L., Zhang X.Y., Zhou B.C., Wang L., Zhang Y.Z.
    ISME J. 5:274-284(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM9913.

Entry informationi

Entry nameiCPDA_PSEU9
AccessioniPrimary (citable) accession number: E6RHP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 8, 2011
Last modified: October 1, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3