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Protein

DNA ligase

Gene

CGB_H3700W

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CGB_H3700WImported
OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)Imported
Taxonomic identifieri367775 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000007805 Componenti: Chromosome H

Organism-specific databases

EuPathDBiFungiDB:CGB_H3700W.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6RB09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTDSPVKA NVRKKRTVIL SDDEDEGLSP PVTKKQLSSP RHSHASDEET
60 70 80 90 100
EPPRKIAKTS SKVAPIFAPK EKREKPPSKA SSTSPKAPTK KTEVKNKDEK
110 120 130 140 150
PLASIFTKSV RKPEPKDDDE VSDEVKQKGK DEEEEDEVYD EIEDKQEGEA
160 170 180 190 200
AVKLASIFTK NQKSVPVADK GWKDGEAVPY SALVSTFEKI EATTKRLEIL
210 220 230 240 250
ELLTQFLLVV AKRDTATDTK GSMLLKVVYL CINRLCPDYM GIELGIGESL
260 270 280 290 300
LVKAIAESTG RAMPKIKEDL KKEGDLGKVA TNSRNTQSTM FKPKPLTVPY
310 320 330 340 350
VFQCLTEIAK ATGNASQAKK VGIIKKLLAA CQSTEAKFII RSLEGKLRIG
360 370 380 390 400
LADKTVVVAL AHAIVLKTIG DKKPSPEKLA IMLEQGAETV KAVYSELPSY
410 420 430 440 450
DLVIPALLQD GVEGLRKHCK LTPGVPLKPM LAKPTKAITE VLDRFEGKEF
460 470 480 490 500
TCEYKYDGER AQVHLLEDGT ISVFSRNSEN MSAKYPDLID QIPRALKPTA
510 520 530 540 550
KTFVIDAEAV AYDLETKKIL PFQDLSRRKR KDVKAEDITV RVHIFAFDLL
560 570 580 590 600
YLNGESLLAK ELKERRRLLQ EHFQPVESEF AFAKSSDGST SEEIQAFLEE
610 620 630 640 650
SVKDGCEGLM VKMLTSEAST YEPSRRSMNW LKLKKDYLSG VGDSLDLVVV
660 670 680 690 700
GAYHGKGKRT AVYGAFLLAC YDPDSEHYQT ICKIGTGFSE EILTKFYELL
710 720 730 740 750
KPLELGVVRG DIEVGGAKPD VWFEPRVVWE VLTADLSLSP VYAAAHGVID
760 770 780 790 800
SRGISLRFPR FIRIRDDKSA DEATTAEQVC EFYQRQVSAS GKKGAGPDVD

DFW
Length:803
Mass (Da):89,068
Last modified:March 8, 2011 - v1
Checksum:i9DC8B5A346FAFAAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000293 Genomic DNA. Translation: ADV23976.1.
RefSeqiXP_003195763.1. XM_003195715.1.

Genome annotation databases

GeneIDi10185600.
KEGGicgi:CGB_H3700W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000293 Genomic DNA. Translation: ADV23976.1.
RefSeqiXP_003195763.1. XM_003195715.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10185600.
KEGGicgi:CGB_H3700W.

Organism-specific databases

EuPathDBiFungiDB:CGB_H3700W.

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WM276 / ATCC MYA-4071Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WM276.

Entry informationi

Entry nameiE6RB09_CRYGW
AccessioniPrimary (citable) accession number: E6RB09
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 29, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.