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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261By similarity
Active sitei446 – 4461By similarity
Active sitei503 – 5031By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:CGB_E0630W
OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Taxonomic identifieri367775 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000007805 Componenti: Chromosome E

Organism-specific databases

EuPathDBiFungiDB:CGB_E0630W.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 573LumenalSequence Analysis
Transmembranei574 – 59421HelicalSequence AnalysisAdd
BLAST
Topological domaini595 – 68793CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 687Pheromone-processing carboxypeptidase KEX1PRO_0000411918
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi367775.XP_003194073.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 356Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E6R6G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNDARARV RSLPSTSSPL ETRDSDEQES SSSQSQRGSR KRGPQRRATE
60 70 80 90 100
LPSAADLYVP SLPGLPDMAT HPTHPLNIYA GMLPSYPGEG KVGGEGETGK
110 120 130 140 150
DAKLYFLMAK ARRNAGKERV IFWFNGGPGC SSFDGSLMEV GPFRTVPASE
160 170 180 190 200
TTTGMVEAKL VEGGWEEFAT VVFVDQPPGT GYSYAATNGY LHDFDELSAH
210 220 230 240 250
FIEFLQNFYT VFPELKGVDT YLAGESFAGQ YIPFFADALI NSAELPNFPL
260 270 280 290 300
KGIAIGNGWI DPKEQYPGYV EFAYEKGLID SGTPVSAAFV DLHKERADQM
310 320 330 340 350
LTDQEAEEME AALKRCQEEM DKYTDPFTTP VNIDHCGEVM DSVTRPFTQE
360 370 380 390 400
LNGKKVCMNV YDVRLVDDFP ACGMNWPPDL PDVYTFLRQD EVISALHASS
410 420 430 440 450
KETAWVECNN KVSYELNLKH SHMSAALLPS ILEAGVPILM FAGAEDLICN
460 470 480 490 500
YKGIERIVNG LEWGGEKGFA NATSQEWYLN GTQVGTWQTS RGLSYAKIFD
510 520 530 540 550
SSHMVGFDVP HVTNDMIMRF MDVDVSLLPG MISQWSSRIG DDERTMIHVG
560 570 580 590 600
DAGEAGGVPL IKGGNTDWEA WYNAVFAFLV LGILVSIVGL YFYFRRKPVS
610 620 630 640 650
YRSRIALKQR GRHRQSHDRD EGDTAERMPL GSERLELDDI ERAEGYEFDD
660 670 680
RDDEGYSGKG KGKGKELADD REEVMFALGD DDEDDRH
Length:687
Mass (Da):76,275
Last modified:March 8, 2011 - v1
Checksum:iF6E945C8D8CB3B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000290 Genomic DNA. Translation: ADV22286.1.
RefSeqiXP_003194073.1. XM_003194025.1.

Genome annotation databases

GeneIDi10190080.
KEGGicgi:CGB_E0630W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000290 Genomic DNA. Translation: ADV22286.1.
RefSeqiXP_003194073.1. XM_003194025.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi367775.XP_003194073.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10190080.
KEGGicgi:CGB_E0630W.

Organism-specific databases

EuPathDBiFungiDB:CGB_E0630W.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WM276 / ATCC MYA-4071.

Entry informationi

Entry nameiKEX1_CRYGW
AccessioniPrimary (citable) accession number: E6R6G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 8, 2011
Last modified: June 24, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.