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E6R6G5 (KEX1_CRYGW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:CGB_E0630W
OrganismCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus) [Complete proteome]
Taxonomic identifier367775 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length687 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 687Pheromone-processing carboxypeptidase KEX1PRO_0000411918

Regions

Topological domain? – 573Lumenal Potential
Transmembrane574 – 59421Helical; Potential
Topological domain595 – 68793Cytoplasmic Potential
Compositional bias30 – 356Poly-Ser

Sites

Active site2261 By similarity
Active site4461 By similarity
Active site5031 By similarity

Amino acid modifications

Glycosylation4711N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E6R6G5 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: F6E945C8D8CB3B77

FASTA68776,275
        10         20         30         40         50         60 
MSGNDARARV RSLPSTSSPL ETRDSDEQES SSSQSQRGSR KRGPQRRATE LPSAADLYVP 

        70         80         90        100        110        120 
SLPGLPDMAT HPTHPLNIYA GMLPSYPGEG KVGGEGETGK DAKLYFLMAK ARRNAGKERV 

       130        140        150        160        170        180 
IFWFNGGPGC SSFDGSLMEV GPFRTVPASE TTTGMVEAKL VEGGWEEFAT VVFVDQPPGT 

       190        200        210        220        230        240 
GYSYAATNGY LHDFDELSAH FIEFLQNFYT VFPELKGVDT YLAGESFAGQ YIPFFADALI 

       250        260        270        280        290        300 
NSAELPNFPL KGIAIGNGWI DPKEQYPGYV EFAYEKGLID SGTPVSAAFV DLHKERADQM 

       310        320        330        340        350        360 
LTDQEAEEME AALKRCQEEM DKYTDPFTTP VNIDHCGEVM DSVTRPFTQE LNGKKVCMNV 

       370        380        390        400        410        420 
YDVRLVDDFP ACGMNWPPDL PDVYTFLRQD EVISALHASS KETAWVECNN KVSYELNLKH 

       430        440        450        460        470        480 
SHMSAALLPS ILEAGVPILM FAGAEDLICN YKGIERIVNG LEWGGEKGFA NATSQEWYLN 

       490        500        510        520        530        540 
GTQVGTWQTS RGLSYAKIFD SSHMVGFDVP HVTNDMIMRF MDVDVSLLPG MISQWSSRIG 

       550        560        570        580        590        600 
DDERTMIHVG DAGEAGGVPL IKGGNTDWEA WYNAVFAFLV LGILVSIVGL YFYFRRKPVS 

       610        620        630        640        650        660 
YRSRIALKQR GRHRQSHDRD EGDTAERMPL GSERLELDDI ERAEGYEFDD RDDEGYSGKG 

       670        680 
KGKGKELADD REEVMFALGD DDEDDRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000290 Genomic DNA. Translation: ADV22286.1.
RefSeqXP_003194073.1. XM_003194025.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10190080.
KEGGcgi:CGB_E0630W.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_CRYGW
AccessionPrimary (citable) accession number: E6R6G5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 8, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries