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E6R6G5

- KEX1_CRYGW

UniProt

E6R6G5 - KEX1_CRYGW

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei226 – 2261By similarity
    Active sitei446 – 4461By similarity
    Active sitei503 – 5031By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:CGB_E0630W
    OrganismiCryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus)
    Taxonomic identifieri367775 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000007805: Chromosome E

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 687Pheromone-processing carboxypeptidase KEX1PRO_0000411918
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini? – 573LumenalSequence Analysis
    Topological domaini595 – 68793CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei574 – 59421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 356Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E6R6G5-1 [UniParc]FASTAAdd to Basket

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    MSGNDARARV RSLPSTSSPL ETRDSDEQES SSSQSQRGSR KRGPQRRATE    50
    LPSAADLYVP SLPGLPDMAT HPTHPLNIYA GMLPSYPGEG KVGGEGETGK 100
    DAKLYFLMAK ARRNAGKERV IFWFNGGPGC SSFDGSLMEV GPFRTVPASE 150
    TTTGMVEAKL VEGGWEEFAT VVFVDQPPGT GYSYAATNGY LHDFDELSAH 200
    FIEFLQNFYT VFPELKGVDT YLAGESFAGQ YIPFFADALI NSAELPNFPL 250
    KGIAIGNGWI DPKEQYPGYV EFAYEKGLID SGTPVSAAFV DLHKERADQM 300
    LTDQEAEEME AALKRCQEEM DKYTDPFTTP VNIDHCGEVM DSVTRPFTQE 350
    LNGKKVCMNV YDVRLVDDFP ACGMNWPPDL PDVYTFLRQD EVISALHASS 400
    KETAWVECNN KVSYELNLKH SHMSAALLPS ILEAGVPILM FAGAEDLICN 450
    YKGIERIVNG LEWGGEKGFA NATSQEWYLN GTQVGTWQTS RGLSYAKIFD 500
    SSHMVGFDVP HVTNDMIMRF MDVDVSLLPG MISQWSSRIG DDERTMIHVG 550
    DAGEAGGVPL IKGGNTDWEA WYNAVFAFLV LGILVSIVGL YFYFRRKPVS 600
    YRSRIALKQR GRHRQSHDRD EGDTAERMPL GSERLELDDI ERAEGYEFDD 650
    RDDEGYSGKG KGKGKELADD REEVMFALGD DDEDDRH 687
    Length:687
    Mass (Da):76,275
    Last modified:March 8, 2011 - v1
    Checksum:iF6E945C8D8CB3B77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000290 Genomic DNA. Translation: ADV22286.1.
    RefSeqiXP_003194073.1. XM_003194025.1.

    Genome annotation databases

    GeneIDi10190080.
    KEGGicgi:CGB_E0630W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000290 Genomic DNA. Translation: ADV22286.1 .
    RefSeqi XP_003194073.1. XM_003194025.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10190080.
    KEGGi cgi:CGB_E0630W.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WM276 / ATCC MYA-4071.

    Entry informationi

    Entry nameiKEX1_CRYGW
    AccessioniPrimary (citable) accession number: E6R6G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3