ID   E6R363_CRYGW            Unreviewed;       614 AA.
AC   E6R363;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Histone deacetylase 1-1 (Hd1), putative {ECO:0000313|EMBL:ADV20987.1};
GN   OrderedLocusNames=CGB_C3150C {ECO:0000313|EMBL:ADV20987.1};
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV20987.1, ECO:0000313|Proteomes:UP000007805};
RN   [1] {ECO:0000313|EMBL:ADV20987.1, ECO:0000313|Proteomes:UP000007805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WM276;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 0:0-0(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000288; ADV20987.1; -; Genomic_DNA.
DR   RefSeq; XP_003192774.1; XM_003192726.1.
DR   AlphaFoldDB; E6R363; -.
DR   GeneID; 10187412; -.
DR   KEGG; cgi:CGB_C3150C; -.
DR   VEuPathDB; FungiDB:CGB_C3150C; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   HOGENOM; CLU_007727_7_4_1; -.
DR   OrthoDB; 1327607at2759; -.
DR   Proteomes; UP000007805; Chromosome C.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF5; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
FT   DOMAIN          100..366
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   614 AA;  68867 MW;  F8F34D2DD4BD9A35 CRC64;
     MPSSVATYPP LDFSSVRSDG RRVAYYYDHD VGNYHFGLGH PMKPHRIRMT HNLVVNYGLA
     DDYETMEEEG KRKVNAQMGM ENDEARWVNA ELRGSRGKWM QIFRPRRATK TDMTRFHTDE
     YIELLESVLP ENVDALTGNG SRGLTGSDCP AVEGIFEFSS ISAGGSIGAA EKLNEGTADI
     AINWAGGLHH AKKTEASGFC YVNDIVLGIL ELLRVNSRVL YIDIDVHHGD GVEEAFYSTD
     RVMTCSFHLF GNFFPGTGTL KDTGLGKGKG YAVNVPLREG ITDQGFHSIF KPVIAEIMEH
     YRPSVIVLQG GADSMSGDKL GRLNLSDKGH AECARFLRTF SVPLMLLGGG GYTTKNVARA
     WTRETAIACG QELSEDLPSN QYMEYYGPRY KLEVLPSNVE DFNTPGYLDD LKRQISKHLK
     NLPFAPSAQM RQVTGRNVSQ AVGLSNEWET DDPEDQIDQR LKILFASKNL NGTYTQESDT
     LLNDLTTASR IRRQGGFKTL PRSSIVFDRG RKRYLEEDVG MEEDPCCHLP AMTGKGKNRK
     SIAMSDSLTP PTSAPEWRSH FTVHEMRKRP YLVETLQQLS PGIEDECDRN RRMTEGSQLH
     MIGQLRRKRS FFLT
//