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Protein

40S ribosomal protein SA

Gene
N/A
Organism
Tetrahymena thermophila
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.UniRule annotation

GO - Molecular functioni

  1. structural constituent of ribosome Source: UniProtKB-HAMAP

GO - Biological processi

  1. ribosomal small subunit assembly Source: UniProtKB-HAMAP
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
OrganismiTetrahymena thermophilaImported
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XZMX-ray3.93B1-241[»]
2XZNX-ray3.93B1-241[»]
4BTSX-ray3.70AB/BB/CB/DB1-241[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S2P family.UniRule annotation

Phylogenomic databases

KOiK02998.

Family and domain databases

HAMAPiMF_03015. Ribosomal_S2_euk.
InterProiIPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEiPS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6PBR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQRKQDDI KRLLASNCHQ ATINLNNQMK RYISHKGVNG IHYINIEETW
60 70 80 90 100
QKIKLAARVI AAVQHPEDVM VVCSRIYGQR AAIKFAGYTH CKSTSSSRWT
110 120 130 140 150
PGTLTNYQTL KYEEPRVLIV TDPRSDFQAI KEASYVNIPV IALCDSDSPL
160 170 180 190 200
AYVDVVIPCN NRSTESISMI YWMIAREVKI LRGELSKDEE WEVMVDLFYH
210 220 230 240
KTLPTAEQKE AEEEEGAEGA EEKVAEVKEG EAEQNTDNKN W
Length:241
Mass (Da):27,498
Last modified:March 8, 2011 - v1
Checksum:iA9903E147B825EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK007908 mRNA. Translation: DAA33965.1.
RefSeqiXP_001014441.2. XM_001014441.2.
UniGeneiTth.3056.

Genome annotation databases

GeneIDi7838059.
KEGGitet:TTHERM_00522630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK007908 mRNA. Translation: DAA33965.1.
RefSeqiXP_001014441.2. XM_001014441.2.
UniGeneiTth.3056.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XZMX-ray3.93B1-241[»]
2XZNX-ray3.93B1-241[»]
4BTSX-ray3.70AB/BB/CB/DB1-241[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7838059.
KEGGitet:TTHERM_00522630.

Phylogenomic databases

KOiK02998.

Family and domain databases

HAMAPiMF_03015. Ribosomal_S2_euk.
InterProiIPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF00318. Ribosomal_S2. 1 hit.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. Sa_S2_E_A. 1 hit.
PROSITEiPS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1."
    Rabl J., Leibundgut M., Ataide S.F., Haag A., Ban N.
    Science 331:730-736(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.93 ANGSTROMS).
  2. "The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A."
    Weisser M., Voigts-Hoffmann F., Rabl J., Leibundgut M., Ban N.
    Nat. Struct. Mol. Biol. 20:1015-1017(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS).

Entry informationi

Entry nameiE6PBR9_TETTH
AccessioniPrimary (citable) accession number: E6PBR9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sourcesImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.