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Protein

Alanine racemase

Gene

alr

Organism
Helicobacter pylori (strain F32)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei319Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL102608:G1H65-445-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HPF32_0418Imported
OrganismiHelicobacter pylori (strain F32)Imported
Taxonomic identifieri102608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000007937 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliE6NNS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 377Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

E6NNS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRASFVEV NSASLRHNFS AVKSIVPKDA HIMAVVKANA YGAGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNAN ASMLIDNDLS
110 120 130 140 150
AMIFSLEQAE VFSQMALKSQ KRLKIHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
IRALKGLEIE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLNQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNGMK ETCPTILKNV
260 270 280 290 300
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNNIQ AKEGDEVILF GDKSAKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYI
Length:377
Mass (Da):41,801
Last modified:March 8, 2011 - v1
Checksum:i01664D7AD2CCF75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011943 Genomic DNA Translation: BAJ58000.1
RefSeqiWP_000917935.1, NC_017366.1

Genome annotation databases

EnsemblBacteriaiBAJ58000; BAJ58000; HPF32_0418
KEGGiheq:HPF32_0418
PATRICifig|102608.4.peg.445

Similar proteinsi

Entry informationi

Entry nameiE6NNS4_HELPL
AccessioniPrimary (citable) accession number: E6NNS4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health