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E6NM03 (E6NM03_HELPL) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icd EMBL BAJ58870.1
Ordered Locus Names:HPF32_1288 EMBL BAJ58870.1
OrganismHelicobacter pylori (strain F32) [Complete proteome] [HAMAP] EMBL BAJ58870.1
Taxonomic identifier102608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
E6NM03 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 7E8AACFB758D8BFD

FASTA42547,512
        10         20         30         40         50         60 
MAYNPKILQK PKEGEEITIK DNKLHVPNRP IIPFIEGDGI GSDITPAMIK VVDSAVQKAY 

        70         80         90        100        110        120 
KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE AINHYKVSIK GPLTTPIGEG 

       130        140        150        160        170        180 
FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV KEPEKVDMVI FRENSEDIYA GIEWQEGSAE 

       190        200        210        220        230        240 
AKKLIHFLQN ELKVKKIRFP ESSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG 

       250        260        270        280        290        300 
NIMKYTEGAF MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL 

       310        320        330        340        350        360 
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT APKYAGLDKV 

       370        380        390        400        410        420 
NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY DFARLMDGAK EVKCSEFASV 


MIENM 

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References

[1]"Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes."
Kawai M., Furuta Y., Yahara K., Tsuru T., Oshima K., Handa N., Takahashi N., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.
BMC Microbiol. 11:104-104(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F32 EMBL BAJ58870.1.
[2]"Birth and death of genes linked to chromosomal inversion."
Furuta Y., Kawai M., Yahara K., Takahashi N., Handa N., Tsuru T., Oshima K., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.
Proc. Natl. Acad. Sci. U.S.A. 108:1501-1506(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F32 EMBL BAJ58870.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP011943 Genomic DNA. Translation: BAJ58870.1.
RefSeqYP_005776512.1. NC_017366.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAJ58870; BAJ58870; HPF32_1288.
GeneID12356135.
KEGGheq:HPF32_1288.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycHPYL102608:GLEE-1325-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE6NM03_HELPL
AccessionPrimary (citable) accession number: E6NM03
Entry history
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)