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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Helicobacter pylori (strain F32)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPYL102608:GLEE-1325-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:HPF32_1288Imported
OrganismiHelicobacter pylori (strain F32)Imported
Taxonomic identifieri102608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007937 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E6NM03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNPKILQK PKEGEEITIK DNKLHVPNRP IIPFIEGDGI GSDITPAMIK
60 70 80 90 100
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE
110 120 130 140 150
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV
160 170 180 190 200
KEPEKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP
210 220 230 240 250
ESSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF
260 270 280 290 300
MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL
310 320 330 340 350
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT
360 370 380 390 400
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY
410 420
DFARLMDGAK EVKCSEFASV MIENM
Length:425
Mass (Da):47,512
Last modified:March 8, 2011 - v1
Checksum:i7E8AACFB758D8BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011943 Genomic DNA. Translation: BAJ58870.1.
RefSeqiWP_000323991.1. NC_017366.1.

Genome annotation databases

EnsemblBacteriaiBAJ58870; BAJ58870; HPF32_1288.
KEGGiheq:HPF32_1288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011943 Genomic DNA. Translation: BAJ58870.1.
RefSeqiWP_000323991.1. NC_017366.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ58870; BAJ58870; HPF32_1288.
KEGGiheq:HPF32_1288.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciHPYL102608:GLEE-1325-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes."
    Kawai M., Furuta Y., Yahara K., Tsuru T., Oshima K., Handa N., Takahashi N., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.
    BMC Microbiol. 11:104-104(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F32Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F32Imported.

Entry informationi

Entry nameiE6NM03_HELPL
AccessioniPrimary (citable) accession number: E6NM03
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 22, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.