Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E6NI94

- E6NI94_HELPK

UniProt

E6NI94 - E6NI94_HELPK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alanine racemase

Gene

alr

Organism
Helicobacter pylori (strain F30)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL866345:GLED-426-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HPF30_0400Imported
OrganismiHelicobacter pylori (strain F30)Imported
Taxonomic identifieri866345 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007936: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE6NI94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E6NI94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKRASFVEV NTASLRHNFS TVKSIVPKDA HIMAVVKANA YGVGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNPN ASMLIDNDLS
110 120 130 140 150
AMIFSLEQAE VFSQMALKSQ KRLKIHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
IRALKGLEIE GIFTHLSNAD SNIKTHAKNQ MKAFNAFLEQ LLNQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRF LNLYRPGIML YGFYPSNGMK ETCPTILKNV
260 270 280 290 300
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNNIQ AKEGDEVILF GDKSAKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYI
Length:377
Mass (Da):41,935
Last modified:March 8, 2011 - v1
Checksum:iF8508456CE40FC4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011941 Genomic DNA. Translation: BAJ56497.1.
RefSeqiWP_000918006.1. NC_017365.1.
YP_005774145.1. NC_017365.1.

Genome annotation databases

EnsemblBacteriaiBAJ56497; BAJ56497; HPF30_0400.
GeneIDi12353759.
KEGGihpf:HPF30_0400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011941 Genomic DNA. Translation: BAJ56497.1 .
RefSeqi WP_000918006.1. NC_017365.1.
YP_005774145.1. NC_017365.1.

3D structure databases

ProteinModelPortali E6NI94.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAJ56497 ; BAJ56497 ; HPF30_0400 .
GeneIDi 12353759.
KEGGi hpf:HPF30_0400.

Phylogenomic databases

KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL866345:GLED-426-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes."
    Kawai M., Furuta Y., Yahara K., Tsuru T., Oshima K., Handa N., Takahashi N., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.
    BMC Microbiol. 11:104-104(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F30Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F30Imported.

Entry informationi

Entry nameiE6NI94_HELPK
AccessioniPrimary (citable) accession number: E6NI94
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3