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Protein

DNA ligase

Gene

Tsp_04168

Organism
Trichinella spiralis (Trichina worm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Tsp_04168Imported
OrganismiTrichinella spiralis (Trichina worm)Imported
Taxonomic identifieri6334 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichocephalidaTrichinellidaeTrichinella
ProteomesiUP000006823: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliE5SIA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiE5SIA4.
KOiK10747.
OMAiLACYDEQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5SIA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFGITVLRL FSRKLLFSTA CCKFPNKYSS IMSQASLTSF FAPKGSADSE
60 70 80 90 100
KRTLSKRKSD LSAVEASNSN PASSVITKDL SKFTEIDEKK RKVQKVDSND
110 120 130 140 150
DRLENDSVKN ASENAACTSK KGYTILAKEN SYIDPKPNIL FISKSTQLVK
160 170 180 190 200
LVKNCFSEQE DVVEPQNYKP DATTYDPECN ACWRAGEQVP YLAFAYTMKA
210 220 230 240 250
IENTSSRLEI IRILSNFFQS VIWLNPDDLL PCIYLCLNRL GPSYEAVELG
260 270 280 290 300
IAEGTLQKAV AQSTGRSMEK IKADIADKGD LGIVAEMSRN MQRTIFATRP
310 320 330 340 350
LTVAGIFAKL NQIAHLSGSS SMNKKLEMVK GLLVSCRDCE ARYLIRCLSG
360 370 380 390 400
KMRIGLAEQS LLVALAHAFA FIERKKENKK KLRDDALKEY LDECALIMKT
410 420 430 440 450
AECPDYGKIV DIALRHGLHA LPEHCHITPG IPLKPMLAFP SKGIEEVLKR
460 470 480 490 500
FGSAEFACEW KYDGERAQIH FYDGTVKVFS RNQENHTGKY PDIVELIPKV
510 520 530 540 550
LSATNNKNNQ TDPISSCIID SEIVAWDTEN QSILPFQVLS TRKRKDAESG
560 570 580 590 600
DVKVNVSVFA FDLLYLNGQS LTTQPFRERR SMLRSLIEEM DGHFFFTKSL
610 620 630 640 650
VTNDSDEIGQ FLEEAVKGNC EGLMLKTLDK DATYEIAKRS HKWLKLKKDY
660 670 680 690 700
LDNTGDTVDL VVIGGYLGVG RRVGVYGGYL LACYNPTTEE YQSICKIGTG
710 720 730 740 750
FKDEDLQKQA EFFKQHIISA PKSYYRYSSS IAPDHWFDPV QVWEVKAADL
760 770 780 790 800
SISPKHFAAI GIVDDEKGIS LRFPRFIRVR DDKNPEDATT AEEVAEIYYN
810 820
QESVKNAKAA ATKDVLSDND VDDDF
Length:825
Mass (Da):92,618
Last modified:March 8, 2011 - v1
Checksum:i5519A76F4A5F5F9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABIR02001012 Genomic DNA. Translation: EFV55486.1.
RefSeqiXP_003374984.1. XM_003374936.1.

Genome annotation databases

EnsemblMetazoaiEFV55486; EFV55486; EFV55486.
GeneIDi10904754.
KEGGitsp:Tsp_04168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABIR02001012 Genomic DNA. Translation: EFV55486.1.
RefSeqiXP_003374984.1. XM_003374936.1.

3D structure databases

ProteinModelPortaliE5SIA4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEFV55486; EFV55486; EFV55486.
GeneIDi10904754.
KEGGitsp:Tsp_04168.

Organism-specific databases

CTDi10904754.

Phylogenomic databases

InParanoidiE5SIA4.
KOiK10747.
OMAiLACYDEQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ISS 195Imported.

Entry informationi

Entry nameiE5SIA4_TRISP
AccessioniPrimary (citable) accession number: E5SIA4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: January 7, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.