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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Tsp_06974

Organism
Trichinella spiralis (Trichina worm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Tsp_06974)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:Tsp_06974Imported
OrganismiTrichinella spiralis (Trichina worm)Imported
Taxonomic identifieri6334 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichocephalidaTrichinellidaeTrichinella
ProteomesiUP000006823 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi6334.EFV59576.

Structurei

3D structure databases

ProteinModelPortaliE5S6M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

InParanoidiE5S6M6.
KOiK00234.
OMAiKWRTCFT.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR003817. PS_Dcarbxylase.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02666. PS_Dcarbxylase. 2 hits.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5S6M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSKLSSVNV NLLKRCLFFN PQAYSSYESR RFVSGYEIVD HTYDAVIVGA
60 70 80 90 100
GGAGLRAAMG LVEAGFKTAV VTKLFPTRSH TVAAQGGVNA ALGNMEPDDW
110 120 130 140 150
RWHFYDTVKG SDWLGDQDAI HYMCREAPRA VLELENYGMP FSRTKEGKIY
160 170 180 190 200
QRAFGGQSLD YGRGGQAHRT CCVADRTGHS MLHTLYGRTL AYDCKYFIEY
210 220 230 240 250
LALDLLMNKN RCVGVIAWNL EDGKLHRFHS NNTILATGGY GRAYFSCTSA
260 270 280 290 300
HTCTGDGTAM VSRAGLPNAD MEFVQFHPTG IYGAGCLITE GVRGEGGYLI
310 320 330 340 350
NSKGERFMER YAPNAKDLAS RDVVSRAMAI EIREGRGVGA QKDHIYLQLH
360 370 380 390 400
HLPANLIHDR LPGIAETAHI FAGVDCTKEP IPVLPTVHYN MGGIPTNHTA
410 420 430 440 450
QVLTFKPGSG DQIIQGLYAA GETAAHSVHG ANRLGANSLL DLVIFGRACA
460 470 480 490 500
LTIAKTCKPG EKFPDLPANA GERSVANLDK LRQANGTITV ADLRLKMQKT
510 520 530 540 550
MQEHASVFRT GEVLQEGCKK MEGIYKQLEN VKLSDRGLIW NTDLVEAIEL
560 570 580 590 600
QNLMLNAVQT INCAEARKES RGAHAREDFK QRIDEFDYSK PLDGQTKLPF
610 620 630 640 650
EKHWRKHSMV WMDEVTGRTR IEYRPVIDKT LDKAEVDWVQ PKVSPADGVV
660 670 680 690 700
QWCGKISDGV LSQIKGITYH INDFFGQVEI PGIDFEDLKT NKKGMRHGSL
710 720 730 740 750
SDLSYSPGYD TEKGRKMGDF RLGSSVVLIF EAPADFHFSV SSGQRIKYGE
760
MLGDINSQAY NLESS
Length:765
Mass (Da):84,641
Last modified:March 8, 2011 - v1
Checksum:iA31A4EBF81F38C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABIR02000599 Genomic DNA. Translation: EFV59576.1.
RefSeqiXP_003380827.1. XM_003380779.1.

Genome annotation databases

EnsemblMetazoaiEFV59576; EFV59576; EFV59576.
GeneIDi10903265.
KEGGitsp:Tsp_06974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABIR02000599 Genomic DNA. Translation: EFV59576.1.
RefSeqiXP_003380827.1. XM_003380779.1.

3D structure databases

ProteinModelPortaliE5S6M6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6334.EFV59576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEFV59576; EFV59576; EFV59576.
GeneIDi10903265.
KEGGitsp:Tsp_06974.

Organism-specific databases

CTDi10903265.

Phylogenomic databases

InParanoidiE5S6M6.
KOiK00234.
OMAiKWRTCFT.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR003817. PS_Dcarbxylase.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02666. PS_Dcarbxylase. 2 hits.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ISS 195Imported.

Entry informationi

Entry nameiE5S6M6_TRISP
AccessioniPrimary (citable) accession number: E5S6M6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 22, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.