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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Tsp_06974

Organism
Trichinella spiralis (Trichina worm)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Tsp_06974), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:Tsp_06974Imported
OrganismiTrichinella spiralis (Trichina worm)Imported
Taxonomic identifieri6334 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichinellidaTrichinellidaeTrichinella
Proteomesi
  • UP000006823 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiE5S6M6

Structurei

3D structure databases

ProteinModelPortaliE5S6M6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 439FAD_binding_2InterPro annotationAdd BLAST396
Domaini494 – 631Succ_DH_flav_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
InParanoidiE5S6M6
KOiK00234
OMAiHWEWHMF
OrthoDBiEOG091G041Z

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR003817 PS_Dcarbxylase
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02666 PS_Dcarbxylase, 2 hits
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

E5S6M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSKLSSVNV NLLKRCLFFN PQAYSSYESR RFVSGYEIVD HTYDAVIVGA
60 70 80 90 100
GGAGLRAAMG LVEAGFKTAV VTKLFPTRSH TVAAQGGVNA ALGNMEPDDW
110 120 130 140 150
RWHFYDTVKG SDWLGDQDAI HYMCREAPRA VLELENYGMP FSRTKEGKIY
160 170 180 190 200
QRAFGGQSLD YGRGGQAHRT CCVADRTGHS MLHTLYGRTL AYDCKYFIEY
210 220 230 240 250
LALDLLMNKN RCVGVIAWNL EDGKLHRFHS NNTILATGGY GRAYFSCTSA
260 270 280 290 300
HTCTGDGTAM VSRAGLPNAD MEFVQFHPTG IYGAGCLITE GVRGEGGYLI
310 320 330 340 350
NSKGERFMER YAPNAKDLAS RDVVSRAMAI EIREGRGVGA QKDHIYLQLH
360 370 380 390 400
HLPANLIHDR LPGIAETAHI FAGVDCTKEP IPVLPTVHYN MGGIPTNHTA
410 420 430 440 450
QVLTFKPGSG DQIIQGLYAA GETAAHSVHG ANRLGANSLL DLVIFGRACA
460 470 480 490 500
LTIAKTCKPG EKFPDLPANA GERSVANLDK LRQANGTITV ADLRLKMQKT
510 520 530 540 550
MQEHASVFRT GEVLQEGCKK MEGIYKQLEN VKLSDRGLIW NTDLVEAIEL
560 570 580 590 600
QNLMLNAVQT INCAEARKES RGAHAREDFK QRIDEFDYSK PLDGQTKLPF
610 620 630 640 650
EKHWRKHSMV WMDEVTGRTR IEYRPVIDKT LDKAEVDWVQ PKVSPADGVV
660 670 680 690 700
QWCGKISDGV LSQIKGITYH INDFFGQVEI PGIDFEDLKT NKKGMRHGSL
710 720 730 740 750
SDLSYSPGYD TEKGRKMGDF RLGSSVVLIF EAPADFHFSV SSGQRIKYGE
760
MLGDINSQAY NLESS
Length:765
Mass (Da):84,641
Last modified:March 8, 2011 - v1
Checksum:iA31A4EBF81F38C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABIR02000599 Genomic DNA Translation: EFV59576.1
RefSeqiXP_003380827.1, XM_003380779.1

Genome annotation databases

EnsemblMetazoaiEFV59576; EFV59576; EFV59576
GeneIDi10903265
KEGGitsp:Tsp_06974

Similar proteinsi

Entry informationi

Entry nameiE5S6M6_TRISP
AccessioniPrimary (citable) accession number: E5S6M6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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