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Protein

Integrin beta

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotation
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiE5RK25.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16.
HGNCiHGNC:6155. ITGB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500319683823 – 160Integrin betaSequence analysisAdd BLAST138

Proteomic databases

MaxQBiE5RK25.
PaxDbiE5RK25.
PeptideAtlasiE5RK25.
PRIDEiE5RK25.

Expressioni

Gene expression databases

BgeeiENSG00000160255.
ExpressionAtlasiE5RK25. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 74PSIInterPro annotationAdd BLAST51
Domaini32 – 159INBInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.

Family and domain databases

InterProiView protein in InterPro
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR002369. Integrin_bsu_VWA.
IPR016201. PSI.
IPR036465. vWFA_dom_sf.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
PfamiView protein in Pfam
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequencei

Sequence statusi: Fragment.

E5RK25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120 130 140 150
QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG
160
GDLLRALNEI
Length:160
Mass (Da):17,644
Last modified:February 8, 2011 - v1
Checksum:i47D31BD3B00E5629
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei160Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000522931; ENSP00000428979; ENSG00000160255.
UCSCiuc062auf.1. human.

Similar proteinsi

Entry informationi

Entry nameiE5RK25_HUMAN
AccessioniPrimary (citable) accession number: E5RK25
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 25, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported