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Protein

Matrix metalloproteinase

Gene

MMP16

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP16Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156103.15.
HGNCiHGNC:7162. MMP16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156103.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiE5RJA7.
PeptideAtlasiE5RJA7.

Expressioni

Gene expression databases

BgeeiENSG00000156103.
ExpressionAtlasiE5RJA7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE5RJA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 113PG_binding_1InterPro annotationAdd BLAST54

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom.
IPR028697. MMP16.
IPR021158. Pept_M10A_Zn_BS.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF168. PTHR10201:SF168. 1 hit.
PfamiView protein in Pfam
PF01471. PG_binding_1. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.

Sequencei

Sequence statusi: Fragment.

E5RJA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDGRYCRRA VLKPGPLSRA GYLRTGRRLD FVHHSGVFFL QTLLWILCAT
60 70 80 90 100
VCGTEQYFNV EVWLQKYGYL PPTDPRMSVL RSAETMQSAL AAMQQFYGIN
110 120 130 140 150
MTGKVDRNTI DWMKKPRCGV PDQTRGSSKF HIRRKRYALT GQKWQHKHIT
160
YSIKNVTPKV GDPETRKA
Length:168
Mass (Da):19,469
Last modified:February 8, 2011 - v1
Checksum:iF023FD5F7A9091C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei168Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC037450 Genomic DNA. No translation available.
AC090575 Genomic DNA. No translation available.
AC090797 Genomic DNA. No translation available.
AC090980 Genomic DNA. No translation available.
KF510324 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000522726; ENSP00000429147; ENSG00000156103.
UCSCiuc064ogt.1. human.

Entry informationi

Entry nameiE5RJA7_HUMAN
AccessioniPrimary (citable) accession number: E5RJA7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 27, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported