ID E5RI87_HUMAN Unreviewed; 419 AA. AC E5RI87; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 27-MAR-2024, entry version 94. DE SubName: Full=Ring finger protein 130 {ECO:0000313|Ensembl:ENSP00000429509.1}; GN Name=RNF130 {ECO:0000313|Ensembl:ENSP00000429509.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429509.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000429509.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000429509.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC026413; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC122713; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_011532895.1; XM_011534593.2. DR AlphaFoldDB; E5RI87; -. DR SMR; E5RI87; -. DR MassIVE; E5RI87; -. DR MaxQB; E5RI87; -. DR PeptideAtlas; E5RI87; -. DR ProteomicsDB; 16215; -. DR Antibodypedia; 2993; 134 antibodies from 24 providers. DR DNASU; 55819; -. DR Ensembl; ENST00000522208.6; ENSP00000429509.1; ENSG00000113269.14. DR UCSC; uc063kss.1; human. DR HGNC; HGNC:18280; RNF130. DR VEuPathDB; HostDB:ENSG00000113269; -. DR GeneTree; ENSGT00940000157465; -. DR OrthoDB; 5474929at2759; -. DR PhylomeDB; E5RI87; -. DR BioGRID-ORCS; 55819; 11 hits in 1205 CRISPR screens. DR ChiTaRS; RNF130; human. DR GenomeRNAi; 55819; -. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000113269; Expressed in monocyte and 200 other cell types or tissues. DR ExpressionAtlas; E5RI87; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd02122; PA_GRAIL_like; 1. DR CDD; cd16803; RING-H2_RNF130; 1. DR Gene3D; 3.50.30.30; -; 1. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1. DR InterPro; IPR046450; PA_dom_sf. DR InterPro; IPR003137; PA_domain. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR46539; E3 UBIQUITIN-PROTEIN LIGASE ATL42; 1. DR PANTHER; PTHR46539:SF27; RING FINGER PROTEIN 130; 1. DR Pfam; PF02225; PA; 1. DR Pfam; PF13639; zf-RING_2; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF52025; PA domain; 1. DR SUPFAM; SSF57850; RING/U-box; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|EPD:E5RI87, KW ECO:0007829|MaxQB:E5RI87}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00175}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..419 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003198011" FT TRANSMEM 195..218 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 264..305 FT /note="RING-type" FT /evidence="ECO:0000259|PROSITE:PS50089" SQ SEQUENCE 419 AA; 46504 MW; C763675F65512102 CRC64; MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG DIIAVMITEL RGKDILSYLE KNISVQMTIA VGTRMPPKNF SRGSLVFVSI SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK AISKLTTRTV KKGDKETDPD FDHCAVCIES YKQNDVVRIL PCKHVFHKSC VDPWLSEHCT CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLAGDN SLGLEPLRTS GISPLPQDGE LTPRTGEINI AVTSGHFFHR NSLSPRSLVY ESEFSTIEPS LDMYDENKT //