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Protein
Submitted name:

Presenilin-2

Gene

PSEN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Presenilin-2Imported
Gene namesi
Name:PSEN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143801.16
HGNCiHGNC:9509 PSEN2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143801

PTM / Processingi

Proteomic databases

MaxQBiE5RHT1
PeptideAtlasiE5RHT1
PRIDEiE5RHT1

Expressioni

Gene expression databases

BgeeiENSG00000143801
ExpressionAtlasiE5RHT1 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiE5RHT1, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliE5RHT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2736 Eukaryota
ENOG410XPZD LUCA
GeneTreeiENSGT00390000016593

Family and domain databases

InterProiView protein in InterPro
IPR001493 Pept_A22A_PS2
IPR001108 Peptidase_A22A
PANTHERiPTHR10202 PTHR10202, 1 hit
PfamiView protein in Pfam
PF01080 Presenilin, 1 hit
PRINTSiPR01074 PRESENILIN2

Sequencei

Sequence statusi: Fragment.

E5RHT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ
60 70 80 90 100
ENEEDGEEDP DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI
110 120
VVVATIKSVR FYTEKNGQLI YTPFTEDTP
Length:129
Mass (Da):14,455
Last modified:February 8, 2011 - v1
Checksum:i09C4AB535E8B4F9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei129Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359732 Genomic DNA No translation available.
AL391628 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000495488; ENSP00000429682; ENSG00000143801
UCSCiuc057pza.1 human

Similar proteinsi

Entry informationi

Entry nameiE5RHT1_HUMAN
AccessioniPrimary (citable) accession number: E5RHT1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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