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Protein
Submitted name:

Presenilin-2

Gene

PSEN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Presenilin-2Imported
Gene namesi
Name:PSEN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9509. PSEN2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143801.

PTM / Processingi

Proteomic databases

MaxQBiE5RHT1.
PaxDbiE5RHT1.
PeptideAtlasiE5RHT1.

Expressioni

Gene expression databases

BgeeiENSG00000143801.
ExpressionAtlasiE5RHT1. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE5RHT1. 2 interactors.
STRINGi9606.ENSP00000355747.

Structurei

3D structure databases

ProteinModelPortaliE5RHT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
GeneTreeiENSGT00390000016593.

Family and domain databases

InterProiIPR001493. Pept_A22A_PS2.
IPR001108. Peptidase_A22A.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF20. PTHR10202:SF20. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01074. PRESENILIN2.

Sequencei

Sequence statusi: Fragment.

E5RHT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ
60 70 80 90 100
ENEEDGEEDP DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI
110 120
VVVATIKSVR FYTEKNGQLI YTPFTEDTP
Length:129
Mass (Da):14,455
Last modified:February 8, 2011 - v1
Checksum:i09C4AB535E8B4F9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei129Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359732 Genomic DNA. No translation available.
AL391628 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000495488; ENSP00000429682; ENSG00000143801.
UCSCiuc057pza.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359732 Genomic DNA. No translation available.
AL391628 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE5RHT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE5RHT1. 2 interactors.
STRINGi9606.ENSP00000355747.

Proteomic databases

MaxQBiE5RHT1.
PaxDbiE5RHT1.
PeptideAtlasiE5RHT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000495488; ENSP00000429682; ENSG00000143801.
UCSCiuc057pza.1. human.

Organism-specific databases

HGNCiHGNC:9509. PSEN2.
OpenTargetsiENSG00000143801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
GeneTreeiENSGT00390000016593.

Miscellaneous databases

ChiTaRSiPSEN2. human.

Gene expression databases

BgeeiENSG00000143801.
ExpressionAtlasiE5RHT1. baseline and differential.

Family and domain databases

InterProiIPR001493. Pept_A22A_PS2.
IPR001108. Peptidase_A22A.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF20. PTHR10202:SF20. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01074. PRESENILIN2.
ProtoNetiSearch...

Entry informationi

Entry nameiE5RHT1_HUMAN
AccessioniPrimary (citable) accession number: E5RHT1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.