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Protein
Submitted name:

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. activated T cell proliferation Source: Ensembl
  2. aging Source: Ensembl
  3. cellular extravasation Source: Ensembl
  4. endothelial cell migration Source: Ensembl
  5. integrin-mediated signaling pathway Source: Ensembl
  6. leukocyte migration involved in inflammatory response Source: Ensembl
  7. natural killer cell activation Source: Ensembl
  8. neutrophil chemotaxis Source: Ensembl
  9. positive regulation of angiogenesis Source: Ensembl
  10. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  11. positive regulation of nitric oxide biosynthetic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta-2Imported
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:6155. ITGB2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. membrane raft Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE5RHE6.
ExpressionAtlasiE5RHE6. baseline and differential.

Structurei

3D structure databases

SMRiE5RHE6. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119064.

Sequencei

Sequence statusi: Fragment.

E5RHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MRGCAADDIM DPTSLAETQE DHNGGQKQLS PQKVTLY
Length:37
Mass (Da):4,049
Last modified:February 8, 2011 - v1
Checksum:iE42EFEB722C57C5E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000524251; ENSP00000430901; ENSG00000160255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

3D structure databases

SMRiE5RHE6. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524251; ENSP00000430901; ENSG00000160255.

Organism-specific databases

HGNCiHGNC:6155. ITGB2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119064.

Miscellaneous databases

ChiTaRSiITGB2. human.
NextBioi35498337.

Gene expression databases

BgeeiE5RHE6.
ExpressionAtlasiE5RHE6. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE5RHE6_HUMAN
AccessioniPrimary (citable) accession number: E5RHE6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 29, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.