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Protein
Submitted name:

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Pleckstrin homology domain-containing family A member 2Imported
Gene namesi
Name:PLEKHA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14336. PLEKHA2.

PTM / Processingi

Proteomic databases

EPDiE5RHB5.
PaxDbiE5RHB5.
PeptideAtlasiE5RHB5.
PRIDEiE5RHB5.

Expressioni

Gene expression databases

BgeeiE5RHB5.
ExpressionAtlasiE5RHB5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393860.

Structurei

3D structure databases

ProteinModelPortaliE5RHB5.
SMRiE5RHB5. Positions 1-113, 199-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 113107PHInterPro annotationAdd
BLAST
Domaini198 – 24952PHInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF2M. Eukaryota.
ENOG410ZQEQ. LUCA.
GeneTreeiENSGT00440000037398.
OrthoDBiEOG7VMP5J.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5RHB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
MGAGAVGALQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
MKDWVEALNQ ASKITVPKGG GLPMTTEVLK SLAAPPALEK KPQVAYKTEI
160 170 180 190 200
IGGVVVHTPI SQNGGDGQEG SEPGSHTILR RSQSYIPTSG CRASTGPPLI
210 220 230 240
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQEFEISL ANMVKPRLY
Length:249
Mass (Da):27,837
Last modified:February 8, 2011 - v1
Checksum:iE7D118B52AE2B061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
KF495718 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000521746; ENSP00000430938; ENSG00000169499.
UCSCiuc064meh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
KF495718 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE5RHB5.
SMRiE5RHB5. Positions 1-113, 199-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393860.

Proteomic databases

EPDiE5RHB5.
PaxDbiE5RHB5.
PeptideAtlasiE5RHB5.
PRIDEiE5RHB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521746; ENSP00000430938; ENSG00000169499.
UCSCiuc064meh.1. human.

Organism-specific databases

HGNCiHGNC:14336. PLEKHA2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2M. Eukaryota.
ENOG410ZQEQ. LUCA.
GeneTreeiENSGT00440000037398.
OrthoDBiEOG7VMP5J.

Miscellaneous databases

ChiTaRSiPLEKHA2. human.

Gene expression databases

BgeeiE5RHB5.
ExpressionAtlasiE5RHB5. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE5RHB5_HUMAN
AccessioniPrimary (citable) accession number: E5RHB5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 6, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.