ENO3

Functionⁱ

GO - Molecular functionⁱ

magnesium ion binding Source: InterPro
phosphopyruvate hydratase activity Source: InterPro

GO - Biological processⁱ

glycolytic process Source: InterPro
substantia nigra development
Source: UniProtKB
Inferred from expression patternⁱ
- 22926577

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Beta-enolaseImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000430055
Gene namesⁱ	Name:ENO3Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000430055
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000430055 Proteomes:UP000005640
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

HGNCⁱ

HGNC:3354. ENO3.

Subcellular locationⁱ

GO - Cellular componentⁱ

phosphopyruvate hydratase complex Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	E5RGZ4.
PeptideAtlasⁱ	E5RGZ4.
PRIDEⁱ	E5RGZ4.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108515.
ExpressionAtlasⁱ	E5RGZ4. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000324105.

STRINGⁱ

9606.ENSP00000324105.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E5RGZ4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	3 – 134	132	Enolase_NInterPro annotation Automatic assertion inferred from signature matchⁱ SMART:SM01193			Add BLAST
Domainⁱ	142 – 283	142	Enolase_CInterPro annotation Automatic assertion inferred from signature matchⁱ SMART:SM01192			Add BLAST

Phylogenomic databases

eggNOGⁱ	KOG2670. Eukaryota. COG0148. LUCA.
GeneTreeⁱ	ENSGT00840000130007.

Family and domain databases

Gene3Dⁱ	3.20.20.120. 1 hit. 3.30.390.10. 1 hit.
InterProⁱ	IPR000941. Enolase. IPR020810. Enolase_C. IPR029065. Enolase_C-like. IPR020811. Enolase_N. IPR029017. Enolase_N-like. [Graphical view]
PANTHERⁱ	PTHR11902. PTHR11902. 1 hit.
Pfamⁱ	PF00113. Enolase_C. 1 hit. PF03952. Enolase_N. 1 hit. [Graphical view]
PRINTSⁱ	PR00148. ENOLASE.
SMARTⁱ	SM01192. Enolase_C. 1 hit. SM01193. Enolase_N. 1 hit. [Graphical view]
SUPFAMⁱ	SSF51604. SSF51604. 1 hit. SSF54826. SSF54826. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

E5RGZ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR 
        60         70         80         90        100
DGDKGRYLGK GVLKAVENIN NTLGPALLQK KLSVVDQEKV DKFMIELDGT 
       110        120        130        140        150
ENKSKFGANA ILGVSLAVCK AGAAEKGVPL YRHIADLAGN PDLILPVPAF 
       160        170        180        190        200
NVINGGSHAG NKLAMQEFMI LPVGASSFKE AMRIGAEVYH HLKGVIKAKY 
       210        220        230        240        250
GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV VIGMDVAASE 
       260        270        280 
FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSF

Length:283

Mass (Da):30,403

Last modified:February 8, 2011 - v1

Checksum:ⁱB4139DBF81B1402F

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Non-terminal residueⁱ	283 – 283	1	Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000430055

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004771 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004771 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000519602; ENSP00000430055; ENSG00000108515.
UCSCⁱ	uc059zyf.1. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004771 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004771 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	E5RGZ4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000324105.

STRINGⁱ

9606.ENSP00000324105.

Proteomic databases

PaxDbⁱ	E5RGZ4.
PeptideAtlasⁱ	E5RGZ4.
PRIDEⁱ	E5RGZ4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000519602; ENSP00000430055; ENSG00000108515.
UCSCⁱ	uc059zyf.1. human.

Organism-specific databases

HGNCⁱ	HGNC:3354. ENO3.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2670. Eukaryota. COG0148. LUCA.
GeneTreeⁱ	ENSGT00840000130007.

Miscellaneous databases

ChiTaRSⁱ	ENO3. human.

ChiTaRSⁱ

ENO3. human.

Gene expression databases

Bgeeⁱ	ENSG00000108515.
ExpressionAtlasⁱ	E5RGZ4. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.20.20.120. 1 hit. 3.30.390.10. 1 hit.
InterProⁱ	IPR000941. Enolase. IPR020810. Enolase_C. IPR029065. Enolase_C-like. IPR020811. Enolase_N. IPR029017. Enolase_N-like. [Graphical view]
PANTHERⁱ	PTHR11902. PTHR11902. 1 hit.
Pfamⁱ	PF00113. Enolase_C. 1 hit. PF03952. Enolase_N. 1 hit. [Graphical view]
PRINTSⁱ	PR00148. ENOLASE.
SMARTⁱ	SM01192. Enolase_C. 1 hit. SM01193. Enolase_N. 1 hit. [Graphical view]
SUPFAMⁱ	SSF51604. SSF51604. 1 hit. SSF54826. SSF54826. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

E5RGZ4_HUMAN

Accessionⁱ

Primary (citable) accession number: E5RGZ4

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	September 7, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E5RGZ4 (E5RGZ4_HUMAN)

UniProt

E5RGZ4 - E5RGZ4_HUMAN

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Beta-enolase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ