ENO3

Functionⁱ

GO - Molecular functionⁱ

magnesium ion binding Source: InterPro
phosphopyruvate hydratase activity Source: InterPro

GO - Biological processⁱ

glycolytic process Source: InterPro
substantia nigra development
Source: UniProtKB
Inferred from expression patternⁱ
- 22926577

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Beta-enolaseImported
Gene namesⁱ	Name:ENO3Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108515.17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3354. ENO3.

Subcellular locationⁱ

GO (Gene Ontology) annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000108515.

OpenTargetsⁱ

ENSG00000108515.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E5RGZ4.
PaxDbⁱ	E5RGZ4.
PeptideAtlas More...PeptideAtlasⁱ	E5RGZ4.
PRIDEⁱ	E5RGZ4.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108515.
ExpressionAtlasⁱ	E5RGZ4. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E5RGZ4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 134	Enolase_NInterPro annotationAdd BLAST		132
Domainⁱ	142 – 283	Enolase_CInterPro annotationAdd BLAST		142

Phylogenomic databases

eggNOGⁱ	KOG2670. Eukaryota. COG0148. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129817.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03313. enolase. 1 hit.
Gene3Dⁱ	3.20.20.120. 1 hit. 3.30.390.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000941. Enolase. IPR020810. Enolase_C. IPR029065. Enolase_C-like. IPR020811. Enolase_N. IPR029017. Enolase_N-like.
PANTHERⁱ	PTHR11902. PTHR11902. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00113. Enolase_C. 1 hit. PF03952. Enolase_N. 1 hit.
PRINTSⁱ	PR00148. ENOLASE.
SMARTⁱ	View protein in SMART SM01192. Enolase_C. 1 hit. SM01193. Enolase_N. 1 hit.
SUPFAMⁱ	SSF51604. SSF51604. 1 hit. SSF54826. SSF54826. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

E5RGZ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR 
        60         70         80         90        100
DGDKGRYLGK GVLKAVENIN NTLGPALLQK KLSVVDQEKV DKFMIELDGT 
       110        120        130        140        150
ENKSKFGANA ILGVSLAVCK AGAAEKGVPL YRHIADLAGN PDLILPVPAF 
       160        170        180        190        200
NVINGGSHAG NKLAMQEFMI LPVGASSFKE AMRIGAEVYH HLKGVIKAKY 
       210        220        230        240        250
GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV VIGMDVAASE 
       260        270        280 
FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSF

Length:283

Mass (Da):30,403

Last modified:February 8, 2011 - v1

Checksum:ⁱB4139DBF81B1402F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	283	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004771 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004771 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000519602; ENSP00000430055; ENSG00000108515.
UCSC genome browser More...UCSCⁱ	uc059zyf.1. human.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E5RGZ4	P13929 H2QBZ4 D3DTL4 K7EKN2 E5RG95 UPI000387CD7B K7EPM1 E5RI09	Homo sapiens (Human) Pan troglodytes (Chimpanzee)	434	UniRef100_P13929	Cluster: Beta-enolase	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E5RGZ4	P13929 H2QBZ4 D3DTL4 K7EKN2 E5RG95 UPI000387CD7B K7EPM1 E5RI09 UPI0004545A0E UPI00022F3C07 +169	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi) Odobenus rosmarus divergens (Pacific walrus) Elephantulus edwardii (Cape long-eared elephant shrew) Physeter catodon (Sperm whale) (Physeter macrocephalus) Dasypus novemcinctus (Nine-banded armadillo) Myotis davidii (David's myotis) And more	434	UniRef90_P13929	Cluster: Beta-enolase	180

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E5RGZ4	P25696 A0A178VT47 A0A1J3JJZ2 O82800 O81663 O81665 A0A1J3ENR5 UPI00053C8DC6 A8IMB0 UPI00053BAF73 +1288	Arabidopsis thaliana (Mouse-ear cress) Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens) Leavenworthia stylosa (Cedar glade-cress) (Nashville mustard) Leavenworthia crassa (Fleshy-fruit glade-cress) Leavenworthia uniflora (Michaux's glade-cress) (Cardamine uniflora) Tarenaya hassleriana Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) Camelina sativa (False flax) (Myagrum sativum) Corchorus olitorius Brassica napus (Rape) And more	444	UniRef50_P25696	Cluster: Bifunctional enolase 2/transcriptional activator	1,299

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004771 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC004771 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	E5RGZ4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E5RGZ4.
PaxDbⁱ	E5RGZ4.
PeptideAtlas More...PeptideAtlasⁱ	E5RGZ4.
PRIDEⁱ	E5RGZ4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000519602; ENSP00000430055; ENSG00000108515.
UCSC genome browser More...UCSCⁱ	uc059zyf.1. human.

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108515.17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3354. ENO3.
Open Targets More...OpenTargetsⁱ	ENSG00000108515.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2670. Eukaryota. COG0148. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129817.

Miscellaneous databases

ChiTaRSⁱ	ENO3. human.

ChiTaRSⁱ

ENO3. human.

Gene expression databases

Bgeeⁱ	ENSG00000108515.
ExpressionAtlasⁱ	E5RGZ4. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03313. enolase. 1 hit.
Gene3Dⁱ	3.20.20.120. 1 hit. 3.30.390.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000941. Enolase. IPR020810. Enolase_C. IPR029065. Enolase_C-like. IPR020811. Enolase_N. IPR029017. Enolase_N-like.
PANTHERⁱ	PTHR11902. PTHR11902. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00113. Enolase_C. 1 hit. PF03952. Enolase_N. 1 hit.
PRINTSⁱ	PR00148. ENOLASE.
SMARTⁱ	View protein in SMART SM01192. Enolase_C. 1 hit. SM01193. Enolase_N. 1 hit.
SUPFAMⁱ	SSF51604. SSF51604. 1 hit. SSF54826. SSF54826. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E5RGZ4_HUMAN
Accessionⁱ	E5RGZ4Primary (citable) accession number: E5RGZ4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 8, 2011
	Last sequence update:	February 8, 2011
	Last modified:	September 27, 2017
	This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E5RGZ4 (E5RGZ4_HUMAN)

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Beta-enolase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ