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Protein

Derlin

Gene

DERL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DerlinUniRule annotation
Gene namesi
Name:DERL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000136986.9.
HGNCiHGNC:28454. DERL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 34HelicalUniRule annotationAdd BLAST28
Transmembranei54 – 86HelicalUniRule annotationAdd BLAST33

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136986.

PTM / Processingi

Proteomic databases

MaxQBiE5RGY0.

Expressioni

Gene expression databases

BgeeiENSG00000136986.
ExpressionAtlasiE5RGY0. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
GeneTreeiENSGT00530000063156.

Family and domain databases

InterProiView protein in InterPro
IPR007599. DER1.
PANTHERiPTHR11009. PTHR11009. 1 hit.

Sequencei

Sequence statusi: Complete.

E5RGY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFNWICIV ITGLAMDMQL LMIPLIMSVL YVWAQLNRDM IVSFWFGTRF
60 70 80 90 100
KACYLPWVIL GFNYIIGGSV INELIGNLVG HLYFFLMFRY PMDLGGRNFL
110 120 130 140 150
STPQFLYRWL PSRRGGVSGF GVPPASMRRA ADQNGGGGRH NWGQGFRLGD

Q
Length:151
Mass (Da):17,221
Last modified:February 8, 2011 - v1
Checksum:i5889A7E679C960DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104316 Genomic DNA. No translation available.
RefSeqiNP_001317530.1. NM_001330601.1.
XP_006716720.1. XM_006716657.1.
UniGeneiHs.241576.

Genome annotation databases

EnsembliENST00000519018; ENSP00000430086; ENSG00000136986.
ENST00000523036; ENSP00000429199; ENSG00000136986.
GeneIDi79139.
UCSCiuc064pwj.1. human.

Similar proteinsi

Entry informationi

Entry nameiE5RGY0_HUMAN
AccessioniPrimary (citable) accession number: E5RGY0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported