ID   E5RGP3_HUMAN            Unreviewed;       115 AA.
AC   E5RGP3;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Pleckstrin homology domain containing A2 {ECO:0000313|Ensembl:ENSP00000429956.1};
DE   Flags: Fragment;
GN   Name=PLEKHA2 {ECO:0000313|Ensembl:ENSP00000429956.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429956.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429956.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429956.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AC067817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E5RGP3; -.
DR   SMR; E5RGP3; -.
DR   MassIVE; E5RGP3; -.
DR   MaxQB; E5RGP3; -.
DR   PeptideAtlas; E5RGP3; -.
DR   ProteomicsDB; 15735; -.
DR   Antibodypedia; 1200; 18 antibodies from 9 providers.
DR   Ensembl; ENST00000519640.5; ENSP00000429956.1; ENSG00000169499.15.
DR   UCSC; uc064mei.1; human.
DR   HGNC; HGNC:14336; PLEKHA2.
DR   VEuPathDB; HostDB:ENSG00000169499; -.
DR   GeneTree; ENSGT00940000158064; -.
DR   HOGENOM; CLU_2114450_0_0_1; -.
DR   OMA; ALKCHPK; -.
DR   ChiTaRS; PLEKHA2; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000169499; Expressed in synovial joint and 190 other cell types or tissues.
DR   ExpressionAtlas; E5RGP3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd13270; PH1_TAPP1_2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR14336:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2; 1.
DR   PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Proteomics identification {ECO:0007829|EPD:E5RGP3,
KW   ECO:0007829|MaxQB:E5RGP3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          7..113
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   NON_TER         115
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000429956.1"
SQ   SEQUENCE   115 AA;  13210 MW;  B8F7B1F676938E82 CRC64;
     MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA MGAGAVGALQ
     LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD MKDWVEALNQ ASKIT
//